Chloroxine
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MedKoo CAT#: 317513

CAS#: 773-76-2

Description: Chloroxine is a synthetic antibacterial agent. It inhibits the growth of Gram-positive and some Gram-negative bacteria and also induces SOS-DNA repair. Chlorxine shows bacteriostatic, fungistatic and antiprotozoal effects in vivo.


Chemical Structure

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Chloroxine
CAS# 773-76-2

Theoretical Analysis

MedKoo Cat#: 317513
Name: Chloroxine
CAS#: 773-76-2
Chemical Formula: C9H5Cl2NO
Exact Mass: 212.97482
Molecular Weight: 214.05
Elemental Analysis: C, 50.50; H, 2.35; Cl, 33.13; N, 6.54; O, 7.47

Price and Availability

Size Price Availability Quantity
1.0g USD 90.0 2 Weeks
2.0g USD 150.0 2 Weeks
5.0g USD 190.0 2 Weeks
10.0g USD 350.0 2 Weeks
20.0g USD 550.0 2 Weeks
50.0g USD 750.0 2 Weeks
100.0g USD 1250.0 2 Weeks
Bulk inquiry

Synonym: Chloroxine; 5,7-Dichloroquinolin-8-ol; 5,7-Dichloro-8-hydroxyquinoline; 773-76-2; Chlorquinol; 5,7-Dichloro-8-quinolinol; chloroxine hydrofluoride; chlorquinol; dichlorohydroxyquinoline; dichloroquine; quixalin;

IUPAC/Chemical Name: 5,7-dichloroquinolin-8-ol

InChi Key: WDFKMLRRRCGAKS-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

SMILES Code: C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 214.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Johnson ML. Fluorescence with chloroxine shampoo. Arch Dermatol. 1979
May;115(5):641. PubMed PMID: 443855.

2: Pérez-Ruiz T, Martínez-Lozano C, Tomás V, Carpena J. Fluorimetric
determination of chloroxine using manual and flow-injection methods. J Pharm
Biomed Anal. 1996 Aug;14(11):1505-11. PubMed PMID: 8877856.

3: Negosanti M, Bettoli V, Valenti R, Patrone P, Celasco G. [Clinical evaluation
on the usefulness of 5,7-dichloro-8-hydroxyquinoline (chloroxine) in association
with betamethasone 17-benzoate in the topical treatment of infected
cortisone-sensitive dermopathies]. G Ital Dermatol Venereol. 1985
Mar-Apr;120(2):XVII-XXIII. Italian. PubMed PMID: 4007946.

4: Stocchi F. [Clinical tests of topical preparations containing betamethasone
17-benzoate and the same associated with 5,7-dichloro-8-hydroxyquinoline
(chloroxine)]. Clin Ter. 1977 Nov 30;83(4):359-69. Italian. PubMed PMID: 603986.

5: Chládek S, Zemlicka J, Gut V. 5-chloro-8-hydroxyquinoline (chloroxine) esters
of carboxylic acid--selective reagents for acylation of nucleoside and nucleotide
aminoacyl derivatives. Biochem Biophys Res Commun. 1969 Apr 29;35(2):306-11.
PubMed PMID: 5772585.