WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317513
Description: Chloroxine is a synthetic antibacterial agent. It inhibits the growth of Gram-positive and some Gram-negative bacteria and also induces SOS-DNA repair. Chlorxine shows bacteriostatic, fungistatic and antiprotozoal effects in vivo.
MedKoo Cat#: 317513
Chemical Formula: C9H5Cl2NO
Exact Mass: 212.97482
Molecular Weight: 214.05
Elemental Analysis: C, 50.50; H, 2.35; Cl, 33.13; N, 6.54; O, 7.47
Synonym: Chloroxine; 5,7-Dichloroquinolin-8-ol; 5,7-Dichloro-8-hydroxyquinoline; 773-76-2; Chlorquinol; 5,7-Dichloro-8-quinolinol; chloroxine hydrofluoride; chlorquinol; dichlorohydroxyquinoline; dichloroquine; quixalin;
IUPAC/Chemical Name: 5,7-dichloroquinolin-8-ol
InChi Key: WDFKMLRRRCGAKS-UHFFFAOYSA-N
InChi Code: InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
SMILES Code: C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 214.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Johnson ML. Fluorescence with chloroxine shampoo. Arch Dermatol. 1979
May;115(5):641. PubMed PMID: 443855.
2: Pérez-Ruiz T, Martínez-Lozano C, Tomás V, Carpena J. Fluorimetric
determination of chloroxine using manual and flow-injection methods. J Pharm
Biomed Anal. 1996 Aug;14(11):1505-11. PubMed PMID: 8877856.
3: Negosanti M, Bettoli V, Valenti R, Patrone P, Celasco G. [Clinical evaluation
on the usefulness of 5,7-dichloro-8-hydroxyquinoline (chloroxine) in association
with betamethasone 17-benzoate in the topical treatment of infected
cortisone-sensitive dermopathies]. G Ital Dermatol Venereol. 1985
Mar-Apr;120(2):XVII-XXIII. Italian. PubMed PMID: 4007946.
4: Stocchi F. [Clinical tests of topical preparations containing betamethasone
17-benzoate and the same associated with 5,7-dichloro-8-hydroxyquinoline
(chloroxine)]. Clin Ter. 1977 Nov 30;83(4):359-69. Italian. PubMed PMID: 603986.
5: Chládek S, Zemlicka J, Gut V. 5-chloro-8-hydroxyquinoline (chloroxine) esters
of carboxylic acid--selective reagents for acylation of nucleoside and nucleotide
aminoacyl derivatives. Biochem Biophys Res Commun. 1969 Apr 29;35(2):306-11.
PubMed PMID: 5772585.