WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317562
CAS#: 5786-21-0 (free base)
Description: Clozapine is an atypical antipsychotic drug because it binds to serotonin as well as dopamine receptors. Clozapine is a partial agonist at the 5-HT1A subunit of the serotonin receptor, putatively improving depression, anxiety, and the negative cognitive symptoms associated with schizophrenia. A direct interaction of clozapine with the GABAB receptor has also been shown. GABAB receptor-deficient mice exhibit increased extracellular dopamine levels and altered locomotor behaviour equivalent to that in schizophrenia animal models.
MedKoo Cat#: 317562
CAS#: 5786-21-0 (free base)
Chemical Formula: C18H19ClN4
Exact Mass: 326.12982
Molecular Weight: 326.82
Elemental Analysis: C, 66.15; H, 5.86; Cl, 10.85; N, 17.14
Synonym: Leponex; Fazaclo; CLOZARIL; 5786-21-0; Clozapin; Clozaril; Leponex
IUPAC/Chemical Name: 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
InChi Key: ZUXABONWMNSFBN-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3
SMILES Code: CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 326.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Meltzer M. Lymphoma developing during clozapine therapy. Aust N Z J Psychiatry. 2015 Dec 16. pii: 0004867415621389. [Epub ahead of print] PubMed PMID: 26681264.
2: Chopra N, de Leon J. Clozapine-induced myocarditis may be associated with rapid titration: A case report verified with autopsy. Int J Psychiatry Med. 2016;51(1):104-15. doi: 10.1177/0091217415621269. PubMed PMID: 26681239.
3: Kumar V, Sharma L, Madival S, Venkatasubramanian G. Successful management of clozapine adverse effects with extended (alternate day) antipsychotic dosing in a patient with schizophrenia. J Psychiatry Neurosci. 2016 Jan;41(1):E1-2. PubMed PMID: 26674512.
4: Grubisha M, Wilson J, Gopalan P, Azzam P. Suspected Secondhand Smoke and Clozapine Toxicity. Psychosomatics. 2015 Nov-Dec;56(6):707-9. doi: 10.1016/j.psym.2015.03.003. Epub 2015 Mar 14. PubMed PMID: 26674484.
5: Pushpakumara J, Karunarathna P, Sivathiran S, Liyanage A, Indrakumar J. Clozapine induced pancytopenia leading to severe sepsis: an unusual early complication. BMC Res Notes. 2015 Dec 16;8(1):792. doi: 10.1186/s13104-015-1777-5. PubMed PMID: 26674072.
6: Balda MV, Daray FM. [Intensive pharmacovigilance of clozapine in Argentina]. Vertex. 2015 Jul-Aug;26(122):292-301. Spanish. PubMed PMID: 26672506.
7: Huang E, Maciukiewicz M, Zai CC, Tiwari AK, Li J, Potkin SG, Lieberman JA, Meltzer HY, Müller DJ, Kennedy JL. Preliminary evidence for association of genome-wide significant DRD2 schizophrenia risk variant with clozapine response. Pharmacogenomics. 2015 Dec 15. [Epub ahead of print] PubMed PMID: 26666695.
8: Malik SA, Malik S, Dowsley TF, Singh B. Left Ventricular Thrombus as a Complication of Clozapine-Induced Cardiomyopathy: A Case Report and Brief Literature Review. Case Rep Cardiol. 2015;2015:835952. doi: 10.1155/2015/835952. Epub 2015 Nov 18. PubMed PMID: 26664756; PubMed Central PMCID: PMC4667025.
9: Piriu G, Torac E, Gaman LE, Iosif L, Tivig IC, Delia C, Gilca M, Stoian I, Atanasiu V. Clozapine and risperidone influence on cortisol and estradiol levels in male patients with schizophrenia. J Med Life. 2015 Oct-Dec;8(4):548-51. PubMed PMID: 26664488; PubMed Central PMCID: PMC4656970.
10: Settem JV, Trivedi S, Kamath AG, Behere RV, Kanaradi H, Bhat SM. Clozapine-induced Supraventricular Tachycardia and its Treatment with Verapamil. Indian J Psychol Med. 2015 Jul-Sep;37(3):358-9. doi: 10.4103/0253-7176.162925. PubMed PMID: 26664091; PubMed Central PMCID: PMC4649798.