WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317561

CAS#: 24166-13-0

Description: Cloxazolam is a drug which is a benzodiazepine derivative. Cloxazolam is metabolised into the active metabolite chlordesmethyldiazepam (delorazepam). It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties.

Chemical Structure

CAS# 24166-13-0

Theoretical Analysis

MedKoo Cat#: 317561
Name: Cloxazolam
CAS#: 24166-13-0
Chemical Formula: C17H14Cl2N2O2
Exact Mass: 348.04323
Molecular Weight: 349.21
Elemental Analysis: C, 58.47; H, 4.04; Cl, 20.30; N, 8.02; O, 9.16

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Sepazon; Olcadil; Akton; Lubalix; Cloxazolazepam; Tolestan; Enadel;

IUPAC/Chemical Name: 10-chloro-11b-(2-chlorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one


InChi Code: InChI=1S/C17H14Cl2N2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 349.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Verplaetse R, Cuypers E, Tytgat J. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood. J Chromatogr A. 2012 Aug 3;1249:147-54. doi: 10.1016/j.chroma.2012.06.023. Epub 2012 Jun 15. PubMed PMID: 22749457.

2: Richards BL, Whittle SL, Buchbinder R. Muscle relaxants for pain management in rheumatoid arthritis. Cochrane Database Syst Rev. 2012 Jan 18;1:CD008922. doi: 10.1002/14651858.CD008922.pub2. Review. PubMed PMID: 22258993.

3: Kimura N, Fujii T, Miyajima T, Kumada T, Mikuni T, Ito M. Initial and long-term effects of cloxazolam with intractable epilepsy. Pediatr Neurol. 2010 Dec;43(6):403-6. doi: 10.1016/j.pediatrneurol.2010.06.005. PubMed PMID: 21093730.

4: Oliveira-Silva D, Oliveira CH, Mendes GD, Galvinas PA, Barrientos-Astigarraga RE, De Nucci G. Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study. Biomed Chromatogr. 2009 Dec;23(12):1266-75. doi: 10.1002/bmc.1249. PubMed PMID: 19488979.

5: Laloup M, Ramirez Fernandez Mdel M, De Boeck G, Wood M, Maes V, Samyn N. Validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of 26 benzodiazepines and metabolites, zolpidem and zopiclone, in blood, urine, and hair. J Anal Toxicol. 2005 Oct;29(7):616-26. PubMed PMID: 16419390.

6: Ito M, Miyajima T, Fujii T, Okuno T. Cloxazolam treatment for patients with intractable epilepsy. Pediatr Neurol. 2004 Feb;30(2):111-4. PubMed PMID: 14984903.

7: Usami N, Yamamoto T, Shintani S, Ishikura S, Higaki Y, Katagiri Y, Hara A. Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5. PubMed PMID: 11995921.

8: Inoue H, Maeno Y, Iwasa M, Matoba R, Nagao M. Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry. Forensic Sci Int. 2000 Sep 11;113(1-3):367-73. PubMed PMID: 10978650.

9: Sakaguchi H, Taguchi H, Ushijima K. [Propofol anesthesia for a schizophrenic patient]. Masui. 1997 Aug;46(8):1127-9. Japanese. PubMed PMID: 9283174.

10: Otsubo K, Seto H, Futagami K, Oishi R. Rapid and sensitive detection of benzodiazepines and zopiclone in serum using high-performance thin-layer chromatography. J Chromatogr B Biomed Appl. 1995 Jul 21;669(2):408-12. PubMed PMID: 7581920.