WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317558

CAS#: 33671-46-4

Description: Clotiazepam is discontinued (DEA controlled substance, DEA Schedule IV). Clotiazepam is a thienodiazepine drug, which is a benzodiazepine analog. The clotiazepam molecule differs from most other benzodiazepines in that the benzene ring has been replaced by a thiophene ring. It possesses anxiolytic, skeletal muscle relaxant, anticonvulsant, sedative properties. Stage 2 NREM sleep is significantly increased by clotiazepam. Similar to other benzodiazepines clotiazepam has anxiolytic, sedative, hypnotic, amnesic, anticonvulsant and muscle relaxant pharmacological properties.

Chemical Structure

CAS# 33671-46-4

Theoretical Analysis

MedKoo Cat#: 317558
Name: Clotiazepam
CAS#: 33671-46-4
Chemical Formula: C16H15ClN2OS
Exact Mass: 318.05936
Molecular Weight: 318.82
Elemental Analysis: C, 60.28; H, 4.74; Cl, 11.12; N, 8.79; O, 5.02; S, 10.06

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Distensan, Clozan, Rizen; Rize; Trecalmo; Tienor; Distensan; Veratran

IUPAC/Chemical Name: 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one


InChi Code: InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 318.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Mizokami F, Takahashi Y, Hasegawa K, Hattori H, Nishihara K, Endo H, Furuta K, Isogai Z. Pressure ulcers induced by drug administration: A new concept and report of four cases in elderly patients. J Dermatol. 2015 Sep 14. doi: 10.1111/1346-8138.13093. [Epub ahead of print] PubMed PMID: 26364579.

2: Kawakami Y, Gokita M, Fukunaga A, Nishigori C. Refractory case of adrenergic urticaria successfully treated with clotiazepam. J Dermatol. 2015 Jun;42(6):635-7. doi: 10.1111/1346-8138.12855. Epub 2015 Mar 21. PubMed PMID: 25810001.

3: Altamura AC, Moliterno D, Paletta S, Maffini M, Mauri MC, Bareggi S. Understanding the pharmacokinetics of anxiolytic drugs. Expert Opin Drug Metab Toxicol. 2013 Apr;9(4):423-40. doi: 10.1517/17425255.2013.759209. Epub 2013 Jan 21. Review. PubMed PMID: 23330992.

4: Verplaetse R, Cuypers E, Tytgat J. The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in urine and blood. J Chromatogr A. 2012 Aug 3;1249:147-54. doi: 10.1016/j.chroma.2012.06.023. Epub 2012 Jun 15. PubMed PMID: 22749457.

5: Wada M, Ito H, Wada M, Wada T, Tada Y, Ishida M, Mizuno K, Shioi A, Narabayashi M, Iwamitsu Y, Onishi H. Drug-induced akathisia as a cause of distress in spouse caregivers of cancer patients. Palliat Support Care. 2011 Jun;9(2):209-12. doi: 10.1017/S1478951511000071. PubMed PMID: 24468489.

6: Toda K. Inclusion of thienodiazepines in prescription rate of anxiolytics. Psychiatry Clin Neurosci. 2009 Jun;63(3):430; author reply 430-1. doi: 10.1111/j.1440-1819.2009.01967.x. PubMed PMID: 19566784.

7: Mandrioli R, Mercolini L, Raggi MA. Benzodiazepine metabolism: an analytical perspective. Curr Drug Metab. 2008 Oct;9(8):827-44. Review. PubMed PMID: 18855614.

8: Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S. Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. Br J Pharmacol. 2008 Oct;155(3):424-33. doi: 10.1038/bjp.2008.271. Epub 2008 Jul 7. PubMed PMID: 18604239; PubMed Central PMCID: PMC2451336.

9: Ahn SH, Maeng HJ, Koo TS, Kim DD, Shim CK, Chung SJ. Quantification of clotiazepam in human plasma by gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Apr 13;834(1-2):128-33. Epub 2006 Mar 6. PubMed PMID: 16517222.

10: Kurisaki E, Hayashida M, Nihira M, Ohno Y, Mashiko H, Okano T, Niwa SI, Hiraiwa K. Diagnostic Performance of Triagetrade mark for Benzodiazepines: Urine Analysis of the Dose of Therapeutic Cases. J Anal Toxicol. 2005;29(6):539-543. PubMed PMID: 16297284.