Hydrochlorothiazide
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MedKoo CAT#: 317511

CAS#: 58-93-5

Description: Hydrochlorothiazide is a thiazide diuretic often used to treat high blood pressure and swelling due to fluid build up. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.


Chemical Structure

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Hydrochlorothiazide
CAS# 58-93-5

Theoretical Analysis

MedKoo Cat#: 317511
Name: Hydrochlorothiazide
CAS#: 58-93-5
Chemical Formula: C7H8ClN3O4S2
Exact Mass: 296.96447
Molecular Weight: 297.74
Elemental Analysis: C, 28.24; H, 2.71; Cl, 11.91; N, 14.11; O, 21.49; S, 21.54

Price and Availability

Size Price Availability Quantity
1.0g USD 90.0 2 Weeks
2.0g USD 150.0 2 Weeks
5.0g USD 250.0 2 Weeks
10.0g USD 450.0 2 Weeks
20.0g USD 650.0 2 Weeks
50.0g USD 950.0 2 Weeks
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Related CAS #: 58-93-5   58-94-5  

Synonym: Hydrochlorothiazide; Hypothiazide; Dichlotride; Hydrosaluric; Esidrex; Esidrix; Dichlothiazide; Dihydrochlorothiazide; Esidrex; Esidrix; HCTZ; Hydrochlorothiazide; HydroDIURIL; Hypothiazide; Oretic; Sectrazide;

IUPAC/Chemical Name: 6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide

InChi Key: JZUFKLXOESDKRF-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

SMILES Code: C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

Appearance: White to off-white crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 297.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Dinç E, Ertekin ZC. Three-way analysis of the UPLC-PDA dataset for the multicomponent quantitation of hydrochlorothiazide and olmesartan medoxomil in tablets by parallel factor analysis and three-way partial least squares. Talanta. 2016 Feb 1;148:144-52. doi: 10.1016/j.talanta.2015.10.074. Epub 2015 Oct 26. PubMed PMID: 26653435.

2: Machnicki G, Ong SH, Chen W, Wei ZJ, Kahler KH. Comparison of amlodipine/valsartan/hydrochlorothiazide single pill combination and free combination: adherence, persistence, healthcare utilization and costs. Curr Med Res Opin. 2015 Dec;31(12):2287-96. doi: 10.1185/03007995.2015.1098598. Epub 2015 Nov 11. PubMed PMID: 26397178.

3: Machini WB, David-Parra DN, Teixeira MF. Electrochemical investigation of the voltammetric determination of hydrochlorothiazide using a nickel hydroxide modified nickel electrode. Mater Sci Eng C Mater Biol Appl. 2015 Dec 1;57:344-8. doi: 10.1016/j.msec.2015.07.035. Epub 2015 Aug 11. PubMed PMID: 26354274.

4: Blatnik SU, Dreu R, Srčič S. Influence of pH modifiers on the dissolution and stability of hydrochlorothiazide in the bi- and three-layer tablets. Acta Pharm. 2015 Dec 1;65(4):383-97. doi: 10.1515/acph-2015-0031. PubMed PMID: 26677896.

5: Arafa MF, El-Gizawy SA, Osman MA, El Maghraby GM. Sucralose as co-crystal co-former for hydrochlorothiazide: development of oral disintegrating tablets. Drug Dev Ind Pharm. 2015 Dec 7:1-9. [Epub ahead of print] PubMed PMID: 26555927.