Hydrochlorothiazide
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MedKoo CAT#: 317511

CAS#: 58-93-5

Description: Hydrochlorothiazide is a thiazide diuretic often used to treat high blood pressure and swelling due to fluid build up. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium.


Chemical Structure

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Hydrochlorothiazide
CAS# 58-93-5

Theoretical Analysis

MedKoo Cat#: 317511
Name: Hydrochlorothiazide
CAS#: 58-93-5
Chemical Formula: C7H8ClN3O4S2
Exact Mass: 296.96447
Molecular Weight: 297.74
Elemental Analysis: C, 28.24; H, 2.71; Cl, 11.91; N, 14.11; O, 21.49; S, 21.54

Size Price Shipping out time Quantity
1g USD 90 2 Weeks
2g USD 150 2 Weeks
5g USD 250 2 Weeks
10g USD 450 2 Weeks
20g USD 650 2 Weeks
50g USD 950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-01. Prices are subject to change without notice.

Hydrochlorothiazide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Related CAS #: 58-93-5   58-94-5  

Synonym: Hydrochlorothiazide; Hypothiazide; Dichlotride; Hydrosaluric; Esidrex; Esidrix; Dichlothiazide; Dihydrochlorothiazide; Esidrex; Esidrix; HCTZ; Hydrochlorothiazide; HydroDIURIL; Hypothiazide; Oretic; Sectrazide;

IUPAC/Chemical Name: 6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide

InChi Key: JZUFKLXOESDKRF-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

SMILES Code: C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

Appearance:
White to off-white crystalline powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 297.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Dinç E, Ertekin ZC. Three-way analysis of the UPLC-PDA dataset for the
multicomponent quantitation of hydrochlorothiazide and olmesartan medoxomil in
tablets by parallel factor analysis and three-way partial least squares. Talanta.
2016 Feb 1;148:144-52. doi: 10.1016/j.talanta.2015.10.074. Epub 2015 Oct 26.
PubMed PMID: 26653435.

2: Machnicki G, Ong SH, Chen W, Wei ZJ, Kahler KH. Comparison of
amlodipine/valsartan/hydrochlorothiazide single pill combination and free
combination: adherence, persistence, healthcare utilization and costs. Curr Med
Res Opin. 2015 Dec;31(12):2287-96. doi: 10.1185/03007995.2015.1098598. Epub 2015
Nov 11. PubMed PMID: 26397178.

3: Machini WB, David-Parra DN, Teixeira MF. Electrochemical investigation of the
voltammetric determination of hydrochlorothiazide using a nickel hydroxide
modified nickel electrode. Mater Sci Eng C Mater Biol Appl. 2015 Dec 1;57:344-8.
doi: 10.1016/j.msec.2015.07.035. Epub 2015 Aug 11. PubMed PMID: 26354274.

4: Blatnik SU, Dreu R, Srčič S. Influence of pH modifiers on the dissolution and
stability of hydrochlorothiazide in the bi- and three-layer tablets. Acta Pharm.
2015 Dec 1;65(4):383-97. doi: 10.1515/acph-2015-0031. PubMed PMID: 26677896.

5: Arafa MF, El-Gizawy SA, Osman MA, El Maghraby GM. Sucralose as co-crystal
co-former for hydrochlorothiazide: development of oral disintegrating tablets.
Drug Dev Ind Pharm. 2015 Dec 7:1-9. [Epub ahead of print] PubMed PMID: 26555927.

6: Arias SC, Souza RA, Malheiros DM, Fanelli C, Fujihara CK, Zatz R. An
Association Of Losartan-Hydrochlorothiazide, But Not Losartan-Furosemide,
Completely Arrests Progressive Injury In The Remnant Kidney. Am J Physiol Renal
Physiol. 2015 Nov 4:ajprenal.00388.2015. doi: 10.1152/ajprenal.00388.2015. [Epub
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7: Nwachukwu DC, Aneke E, Nwachukwu NZ, Obika L, Nwagha UI, Eze AA. Effect of
Hibiscus sabdariffaon blood pressure and electrolyte profile of mild to moderate
hypertensive Nigerians: A comparative study with hydrochlorothiazide. Niger J
Clin Pract. 2015 Nov-Dec;18(6):762-70. doi: 10.4103/1119-3077.163278. PubMed
PMID: 26289514.

8: Liu TT, Xiang LL, Wang JL, Chen DY. Application of capillary
electrophoresis-frontal analysis for comparative evaluation of the binding
interaction of captopril with human serum albumin in the absence and presence of
hydrochlorothiazide. J Pharm Biomed Anal. 2015 Nov 10;115:31-5. doi:
10.1016/j.jpba.2015.06.022. Epub 2015 Jun 20. PubMed PMID: 26142561.

9: Ahmad Panahi H, Ejlali M, Chabouk M. Two phase and three phase liquid phase
microextraction of hydrochlorothiazide and triamterene in urine samples. Biomed
Chromatogr. 2015 Nov 6. doi: 10.1002/bmc.3645. [Epub ahead of print] PubMed PMID:
26542449.

10: Reddy YN, Deshmukh AJ. Hydrochlorothiazide--Teaching an Old Drug New Tricks.
J Clin Hypertens (Greenwich). 2015 Nov;17(11):855-6. doi: 10.1111/jch.12626. Epub
2015 Jul 20. PubMed PMID: 26192025.

11: Brown MJ, Williams B, Morant SV, Webb DJ, Caulfield MJ, Cruickshank JK, Ford
I, McInnes G, Sever P, Salsbury J, Mackenzie IS, Padmanabhan S, MacDonald TM;
British Hypertension Society's Prevention; Treatment of Hypertension with
Algorithm-based Therapy (PATHWAY) Studies Group. Effect of amiloride, or
amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose
tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind
randomised phase 4 trial. Lancet Diabetes Endocrinol. 2015 Oct 16. pii:
S2213-8587(15)00377-0. doi: 10.1016/S2213-8587(15)00377-0. [Epub ahead of print]
PubMed PMID: 26489809.

12: Hosaka M, Metoki H, Satoh M, Ohkubo T, Asayama K, Kikuya M, Inoue R, Obara T,
Hirose T, Imai Y. Randomized trial comparing the velocities of the
antihypertensive effects on home blood pressure of candesartan and candesartan
with hydrochlorothiazide. Hypertens Res. 2015 Oct;38(10):701-7. doi:
10.1038/hr.2015.64. Epub 2015 Jun 4. PubMed PMID: 26041602.

13: Derosa G, Querci F, Franzetti I, Dario Ragonesi P, D'Angelo A, Maffioli P.
Comparison of the effects of barnidipine+losartan compared with
telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in
patients with hypertension and type 2 diabetes mellitus. Hypertens Res. 2015
Oct;38(10):690-4. doi: 10.1038/hr.2015.57. Epub 2015 May 21. PubMed PMID:
25994603.

14: Yousefichaijan P, Sharafkhah M, Cyrus A, Rafeie M. Therapeutic Efficacy of
Hydrochlorothiazide in Primary Monosymptomatic Nocturnal Enuresis in Boys With
Idiopathic Hypercalciuria. Nephrourol Mon. 2015 Sep 16;7(5):e29127. doi:
10.5812/numonthly.29127. eCollection 2015 Sep. PubMed PMID: 26543832; PubMed
Central PMCID: PMC4630497.

15: Jarvis SS, Okada Y, Levine BD, Fu Q. Central integration and neural control
of blood pressure during the cold pressor test: a comparison between
hydrochlorothiazide and aliskiren. Physiol Rep. 2015 Sep 14;3(9). pii: e12502.
doi: 10.14814/phy2.12502. Epub 2015 Sep 15. PubMed PMID: 26465969; PubMed Central
PMCID: PMC4600375.

16: Giménez-García R. Hyperpigmentation Induced by Combination Therapy With
Telmisartan-Hydrochlorothiazide. J Clin Hypertens (Greenwich). 2015 Sep 11. doi:
10.1111/jch.12665. [Epub ahead of print] PubMed PMID: 26360127.

17: Yu D, Chen Y, Hao K. The pharmacokinetic-pharmacodynamic model of telmisartan
and hydrochlorothiazide on blood pressure and plasma potassium after long-term
administration in spontaneously hypertensive rats. Fundam Clin Pharmacol. 2015
Sep 10. doi: 10.1111/fcp.12152. [Epub ahead of print] PubMed PMID: 26354414.

18: Mohan JC, Jain R, Chamle V, Bhargava A. Short Term Safety and Tolerability of
a Fixed Dose Combination of Olmesartan, Amlodipine and Hydrochlorothiazide. J
Clin Diagn Res. 2015 Aug;9(8):OC10-3. doi: 10.7860/JCDR/2015/14054.6366. Epub
2015 Aug 1. PubMed PMID: 26435982; PubMed Central PMCID: PMC4576575.

19: Lorena M, Autolitano A, Natale G, Uberti F, Vitali F, Schiantarelli C,
Liberato NL. Telmisartan/hydrochlorothiazide-induced hepatotoxicity. Arch Med
Sci. 2015 Aug 12;11(4):893-4. doi: 10.5114/aoms.2015.53311. Epub 2015 Aug 11.
PubMed PMID: 26322103; PubMed Central PMCID: PMC4548043.

20: Cooney D, Milfred-LaForest S, Rahman M. Diuretics for hypertension:
Hydrochlorothiazide or chlorthalidone? Cleve Clin J Med. 2015 Aug;82(8):527-33.
doi: 10.3949/ccjm.82a.14091. Review. PubMed PMID: 26270432.