WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407230
CAS#: 1338483-67-2
Description: AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.
MedKoo Cat#: 407230
Name: AM-8508
CAS#: 1338483-67-2
Chemical Formula: C19H15FN8
Exact Mass: 374.1404
Molecular Weight: 374.14
Elemental Analysis: C, 60.96; H, 4.04; F, 5.07; N, 29.93
Synonym: AM-8508; AM 8508; AM8508.
IUPAC/Chemical Name: (S)-4-amino-6-((1-(6-fluoro-1-(pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile
InChi Key: FQJBNNUXCQXZSV-NSHDSACASA-N
InChi Code: InChI=1S/C19H15FN8/c1-11(26-18-14(8-21)17(22)24-10-25-18)19-27-15-5-4-12(20)7-16(15)28(19)13-3-2-6-23-9-13/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
SMILES Code: N#CC1=C(N[C@H](C2=NC3=CC=C(F)C=C3N2C4=CC=CN=C4)C)N=CN=C1N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 374.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors
Youngsook Shin, Julia Suchomel, Mario Cardozo, Jason Duquette, Xiao He, Kirk Henne, Yi-Ling Hu, Ron C. Kelly, John McCarter, Lawrence R. McGee, Julio C. Medina, Daniela Metz, Tisha San Miguel, Deanna Mohn, Thuy Tran, Christine Vissinga, Simon Wong, Sharon Wannberg, Douglas A. Whittington, John Whoriskey, Gang Yu, Leeanne Zalameda, Xuxia Zhang, and Timothy D. Cushing
Publication Date (Web): December 10, 2015 (Article)
DOI: 10.1021/acs.jmedchem.5b01651
