WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407230
Description: AM-8508 is a potent and selective PI3Kδ inhibitor. AM-8508 showed good cellular potency (in vitro pAKT IC50 = 4.6 nM ). AM-8505 xhibited excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibit KLH-specific antibodies in animal models, signifying its potential for the treatment of human inflammatory diseases. PI3Kα and PI3Kβ are ubiquitously expressed and play a role in cell growth, division, and survival.
MedKoo Cat#: 407230
Chemical Formula: C19H15FN8
Exact Mass: 374.1404
Molecular Weight: 374.14
Elemental Analysis: C, 60.96; H, 4.04; F, 5.07; N, 29.93
AM-8508, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: AM-8508; AM 8508; AM8508.
IUPAC/Chemical Name: (S)-4-amino-6-((1-(6-fluoro-1-(pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile
InChi Key: FQJBNNUXCQXZSV-NSHDSACASA-N
InChi Code: InChI=1S/C19H15FN8/c1-11(26-18-14(8-21)17(22)24-10-25-18)19-27-15-5-4-12(20)7-16(15)28(19)13-3-2-6-23-9-13/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1
SMILES Code: N#CC1=C(N[C@H](C2=NC3=CC=C(F)C=C3N2C4=CC=CN=C4)C)N=CN=C1N
The following data is based on the product molecular weight 374.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors
Youngsook Shin, Julia Suchomel, Mario Cardozo, Jason Duquette, Xiao He, Kirk Henne, Yi-Ling Hu, Ron C. Kelly, John McCarter, Lawrence R. McGee, Julio C. Medina, Daniela Metz, Tisha San Miguel, Deanna Mohn, Thuy Tran, Christine Vissinga, Simon Wong, Sharon Wannberg, Douglas A. Whittington, John Whoriskey, Gang Yu, Leeanne Zalameda, Xuxia Zhang, and Timothy D. Cushing
Publication Date (Web): December 10, 2015 (Article)