WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319571
Description: Erlosiban, also known as OBE001, is a novel, orally active nonpeptide oxytocin receptor antagonist under development for the treatment of preterm labor and improvement in embryo implantation and pregnancy rate in assisted reproductive technology (ART).
MedKoo Cat#: 319571
Chemical Formula: C20H22N2O3
Exact Mass: 338.163
Molecular Weight: 338.41
Elemental Analysis: C, 70.99; H, 6.55; N, 8.28; O, 14.18
Synonym: OBE-001; OBE001; OBE001; Erlosiban
IUPAC/Chemical Name: [(2S,4Z)-2-(hydroxymethyl)-4-(methoxyimino)pyrrolidin-1-yl](2'-methyl[1,1'-biphenyl]-4-yl)methanone
InChi Key: OLUJSZLBWZWGJT-HGBKYHTQSA-N
InChi Code: InChI=1S/C20H22N2O3/c1-14-5-3-4-6-19(14)15-7-9-16(10-8-15)20(24)22-12-17(21-25-2)11-18(22)13-23/h3-10,18,23H,11-13H2,1-2H3/b21-17-/t18-/m0/s1
SMILES Code: O=C(N1[C@H](CO)C/C(C1)=N/OC)C2=CC=C(C3=CC=CC=C3C)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 338.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Pohl O, Perks D, Rhodes J, Comotto L, Baldrick P, Chollet A. Effects of the
Oral Oxytocin Receptor Antagonist Tocolytic OBE001 on Reproduction in Rats.
Reprod Sci. 2015 Sep 23. pii: 1933719115607979. [Epub ahead of print] PubMed
2: Pohl O, Homery MC, Lemaux F, Patat A, Chollet A. Pharmacokinetic interactions
of OBE001 and betamethasone in healthy female volunteers. J Clin Pharm Ther. 2015
Jun;40(3):328-32. doi: 10.1111/jcpt.12258. Epub 2015 Feb 26. PubMed PMID: