Erlosiban

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319571

CAS#: 1477482-19-1

Description: Erlosiban, also known as OBE001, is a novel, orally active nonpeptide oxytocin receptor antagonist under development for the treatment of preterm labor and improvement in embryo implantation and pregnancy rate in assisted reproductive technology (ART).


Chemical Structure

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Erlosiban
CAS# 1477482-19-1

Theoretical Analysis

MedKoo Cat#: 319571
Name: Erlosiban
CAS#: 1477482-19-1
Chemical Formula: C20H22N2O3
Exact Mass: 338.163
Molecular Weight: 338.41
Elemental Analysis: C, 70.99; H, 6.55; N, 8.28; O, 14.18

Size Price Shipping out time Quantity
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Pricing updated 2021-03-01. Prices are subject to change without notice.

Erlosiban is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: OBE-001; OBE001; OBE001; Erlosiban

IUPAC/Chemical Name: [(2S,4Z)-2-(hydroxymethyl)-4-(methoxyimino)pyrrolidin-1-yl](2'-methyl[1,1'-biphenyl]-4-yl)methanone

InChi Key: OLUJSZLBWZWGJT-HGBKYHTQSA-N

InChi Code: InChI=1S/C20H22N2O3/c1-14-5-3-4-6-19(14)15-7-9-16(10-8-15)20(24)22-12-17(21-25-2)11-18(22)13-23/h3-10,18,23H,11-13H2,1-2H3/b21-17-/t18-/m0/s1

SMILES Code: O=C(N1[C@H](CO)C/C(C1)=N/OC)C2=CC=C(C3=CC=CC=C3C)C=C2

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 338.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pohl O, Perks D, Rhodes J, Comotto L, Baldrick P, Chollet A. Effects of the
Oral Oxytocin Receptor Antagonist Tocolytic OBE001 on Reproduction in Rats.
Reprod Sci. 2015 Sep 23. pii: 1933719115607979. [Epub ahead of print] PubMed
PMID: 26399985.

2: Pohl O, Homery MC, Lemaux F, Patat A, Chollet A. Pharmacokinetic interactions
of OBE001 and betamethasone in healthy female volunteers. J Clin Pharm Ther. 2015
Jun;40(3):328-32. doi: 10.1111/jcpt.12258. Epub 2015 Feb 26. PubMed PMID:
25899007.