Erlosiban

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319571

CAS#: 1477482-19-1

Description: Erlosiban, also known as OBE001, is a novel, orally active nonpeptide oxytocin receptor antagonist under development for the treatment of preterm labor and improvement in embryo implantation and pregnancy rate in assisted reproductive technology (ART).

Chemical Structure

Erlosiban

CAS# 1477482-19-1

Instruction

Theoretical Analysis

MedKoo Cat#: 319571
Name: Erlosiban
CAS#: 1477482-19-1
Chemical Formula: C20H22N2O3
Exact Mass: 338.163
Molecular Weight: 338.41
Elemental Analysis: C, 70.99; H, 6.55; N, 8.28; O, 14.18

Price and Availability

Size	Price	Availability	Quantity
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: OBE-001; OBE001; OBE001; Erlosiban

IUPAC/Chemical Name: [(2S,4Z)-2-(hydroxymethyl)-4-(methoxyimino)pyrrolidin-1-yl](2'-methyl[1,1'-biphenyl]-4-yl)methanone

InChi Key: OLUJSZLBWZWGJT-HGBKYHTQSA-N

InChi Code: InChI=1S/C20H22N2O3/c1-14-5-3-4-6-19(14)15-7-9-16(10-8-15)20(24)22-12-17(21-25-2)11-18(22)13-23/h3-10,18,23H,11-13H2,1-2H3/b21-17-/t18-/m0/s1

SMILES Code: O=C(N1[C@H](CO)C/C(C1)=N/OC)C2=CC=C(C3=CC=CC=C3C)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Instruction:

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Preparing Stock Solutions

The following data is based on the product molecular weight 338.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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1: Pohl O, Perks D, Rhodes J, Comotto L, Baldrick P, Chollet A. Effects of the
Oral Oxytocin Receptor Antagonist Tocolytic OBE001 on Reproduction in Rats.
Reprod Sci. 2015 Sep 23. pii: 1933719115607979. [Epub ahead of print] PubMed
PMID: 26399985.

2: Pohl O, Homery MC, Lemaux F, Patat A, Chollet A. Pharmacokinetic interactions
of OBE001 and betamethasone in healthy female volunteers. J Clin Pharm Ther. 2015
Jun;40(3):328-32. doi: 10.1111/jcpt.12258. Epub 2015 Feb 26. PubMed PMID:
25899007.

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Erlosiban

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