BFH772
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407229

CAS#: 890128-81-1

Description: BFH772, a structure analogue of BAW2881, is a potent and selective VEGF inhibitor. BFH772 is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM. BFH772 inhibits the ligand induced autophosphorylation of RET, PDGFR, and KIT kinases, with IC50 values ranging between 30 and 160 nM.


Chemical Structure

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BFH772
CAS# 890128-81-1

Theoretical Analysis

MedKoo Cat#: 407229
Name: BFH772
CAS#: 890128-81-1
Chemical Formula: C23H16F3N3O3
Exact Mass: 439.1144
Molecular Weight: 439.39
Elemental Analysis: 62.87; H, 3.67; F, 12.97; N, 9.56; O, 10.92

Size Price Shipping out time Quantity
100mg USD 950 2 weeks
200mg USD 1650 2 weeks
500mg USD 2150 2 weeks
1g USD 3250 2 weeks
2g USD 4950 2 weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-26. Prices are subject to change without notice.

BFH772, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: BFH-772; BFH 772; BFH772.

IUPAC/Chemical Name: 6-((6-(hydroxymethyl)pyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide

InChi Key: JNLSTLQFDDAULK-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H16F3N3O3/c24-23(25,26)15-4-2-5-16(10-15)29-22(31)20-6-1-3-14-9-18(7-8-19(14)20)32-21-11-17(12-30)27-13-28-21/h1-11,13,30H,12H2,(H,29,31)

SMILES Code: O=C(C1=C2C=CC(OC3=NC=NC(CO)=C3)=CC2=CC=C1)NC4=CC=CC(C(F)(F)F)=C4

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 439.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis
Guido Bold, Christian Schnell, Pascal Furet, Paul McSheehy, Josef Brüggen, Jürgen Mestan, Paul W. Manley, Peter Drückes, Marion Burglin, Ursula Dürler, Jacqueline Loretan, Robert Reuter, Markus Wartmann, Andreas Theuer, Beatrice Bauer-Probst, Georg Martiny-Baron, Peter Allegrini, Arnaud Goepfert, Jeanette Wood, and Amanda Littlewood-Evans
Publication Date (Web): December 2, 2015 (Article)
DOI: 10.1021/acs.jmedchem.5b01582