Chloropyramine
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MedKoo CAT#: 317509

CAS#: 59-32-5

Description: Chloropyramine is a first generation antihistamine drug approved for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Chloropyramine is known as a competitive reversible H1-receptor antagonist, meaning that it exerts its pharmacological action by competing with histamine for the H1 subtype histamine receptor. By blocking the effects of histamine, the drug inhibits the vasodilation, increased vascular permeability, and tissue edema associated with histamine release in the tissue.


Chemical Structure

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Chloropyramine
CAS# 59-32-5

Theoretical Analysis

MedKoo Cat#: 317509
Name: Chloropyramine
CAS#: 59-32-5
Chemical Formula: C16H20ClN3
Exact Mass: 289.13458
Molecular Weight: 289.8
Elemental Analysis: C, 66.31; H, 6.96; Cl, 12.23; N, 14.50

Price and Availability

Size Price Availability Quantity
100.0mg USD 150.0 2 Weeks
200.0mg USD 250.0 2 Weeks
500.0mg USD 450.0 2 Weeks
1.0g USD 650.0 2 Weeks
2.0g USD 950.0 2 Weeks
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Synonym: Chloropyramine; Halopyramine; Chlorpyramine; Suprastin; Avapena; Synopen; Anaphylline; Chlorneoantergan

IUPAC/Chemical Name: N'-[(4-chlorophenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine

InChi Key: ICKFFNBDFNZJSX-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H20ClN3/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14/h3-10H,11-13H2,1-2H3

SMILES Code: CN(C)CCN(CC1=CC=C(C=C1)Cl)C2=CC=CC=N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 289.8 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kurenova EV, Hunt DL, He D, Magis AT, Ostrov DA, Cance WG. Small molecule
chloropyramine hydrochloride (C4) targets the binding site of focal adhesion
kinase and vascular endothelial growth factor receptor 3 and suppresses breast
cancer growth in vivo. J Med Chem. 2009 Aug 13;52(15):4716-24. doi:
10.1021/jm900159g. PubMed PMID: 19610651; PubMed Central PMCID: PMC2765121.

2: Durand-Arczynska W, Schoenenweid F, Durand J. Effects of chloropyramine,
dimethindene and diphenhydramine on transepithelial ion transport: studies in
bovine tracheal epithelium and frog skin. J Physiol (Paris). 1986;81(3):185-90.
PubMed PMID: 2879040.

3: Idänpään-Heikkilä J, Saxén L. Possible teratogenicity of
imipramine-chloropyramine. Lancet. 1973 Aug 11;2(7824):282-4. PubMed PMID:
4124771.

4: Budihna M, Drevensek G, Burjak M, Kocijancic S. Effects of chloropyramine and
famotidine on postischaemic and posthypoxic myocardial damage in isolated rat
hearts. Pflugers Arch. 1996;431(6 Suppl 2):R217-8. PubMed PMID: 8739342.

5: Dessouky YM, Mousa BA, Nour el-Din HM. Dye-salt formation as a general method
for colorimetric determination of antihistaminics. I. The use of methyl orange
for the determination of chlorphenamine, diphenhydramine and chloropyramine in
pharmaceutical preparations. Pharmazie. 1974 Sep;29(9):577-8. PubMed PMID:
4154006.

6: VASILIEV R, SCINTEE-PAZARINA V. [THE DETERMINATION OF CHLOROPYRAMINE BY
TITRATION IN WATER-FREE MEDIUM]. Pharmazie. 1963 Nov;18:746-7. German. PubMed
PMID: 14206112.