WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317508
CAS#: 3858-89-7 (HCl)
Description: Chloroprocaine Hydrochloride is a synthetic, local anesthetic agent. At the injection site, chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma.
MedKoo Cat#: 317508
Name: Chloroprocaine Hydrochloride
CAS#: 3858-89-7 (HCl)
Chemical Formula: C13H20Cl2N2O2
Exact Mass:
Molecular Weight: 307.22
Elemental Analysis: C, 50.82; H, 6.56; Cl, 23.08; N, 9.12; O, 10.42
Related CAS #: 133-16-4 （free base) 3858-89-7 (HCl)
Synonym: Chloroprocaine Hydrochloride; CHEBI:3637; UNII-LT7Z1YW11H; NCGC00183273-01; Nesacaine (TN); Nesacaine MPF;
IUPAC/Chemical Name: 2-(diethylamino)ethyl 4-amino-2-chlorobenzoate;hydrochloride
InChi Key: SZKQYDBPUCZLRX-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H19ClN2O2.ClH/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14;/h5-6,9H,3-4,7-8,15H2,1-2H3;1H
SMILES Code: CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 307.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Columb MO, Lyons G, Naughton NN, Becton WW. Determination of the minimum local
analgesic concentration of epidural chloroprocaine hydrochloride in labor. Int J
Obstet Anesth. 1997 Jan;6(1):39-42. PubMed PMID: 15321309.
2: TRAVIN MS. USE OF 2-CHLOROPROCAINE HYDROCHLORIDE AS AN ANESTHETIC AGENT FOR
ORAL SURGERY: CLINCIAL IMPRESSIONS. J Oral Ther Pharmacol. 1965 May;1:637-40.
PubMed PMID: 14292260.
3: WALL B. The use of chloroprocaine hydrochloride (nesacaine) for topical
anesthesia in the genitourinary tract. J Urol. 1959 Jul;82(1):168-70. PubMed
PMID: 13665829.
4: ORBACH EJ. Chloroprocaine hydrochloride: clinical evaluation in office
surgery. Am Pract Dig Treat. 1959 Feb;10(2):231-4. PubMed PMID: 13627399.
5: Menon G, Norris B, Webster J. Simultaneous determination of chloroprocaine
hydrochloride and its degradation product 4-amino-2-chlorobenzoic acid in bulk
drug and injection solutions by high-performance liquid chromatography. J Pharm
Sci. 1984 Feb;73(2):251-3. PubMed PMID: 6707895.
6: Scott DB. Chloroprocaine hydrochloride and obstetric analgesia. Anaesthesia.
1980 May;35(5):518. PubMed PMID: 7396160.
7: Allen PR, Johnson RW. Extradural analgesia in labour. A comparison of
2-chloroprocaine hydrochloride and bupivacaine hydrochloride. Anaesthesia. 1979
Oct;34(9):839-43. PubMed PMID: 532919.
8: KRUMPERMAN LW, MESCHTER SC, CLOSE EL, WESTER MR, ERICKSON JC, STRENGE HJ.
Transdural diffusion of 2-chloroprocaine hydrochloride in man. Anesth Analg. 1960
Jan-Feb;39:55-8. PubMed PMID: 14412260.
9: CHLOROPROCAINE hydrochloride. J Am Med Assoc. 1957 Jan 5;163(1):38-9. PubMed
PMID: 13376341.
10: COLAVINCENZO JW, FOLDES FF, MCNALL PG, FRIDAY RH. The use of 2-chloroprocaine
hydrochloride for epidural block in outpatients. Pa Med J. 1956 Mar;59(3):338-40.
PubMed PMID: 13297535.
