Clonidine
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317555

CAS#: 4205-90-7 (free base)

Description: Clonidine (also known as Catapres, Kapvay, Nexiclon, and Clophelin) is a sympathomimetic medication used to treat high blood pressure, attention deficit hyperactivity disorder, anxiety disorders, withdrawal (from either alcohol, opioids, or smoking), migraine, menopausal flushing, diarrhea, and certain pain conditions. It is classified as a centrally acting α2 adrenergic agonist and imidazoline receptor agonist that has been in clinical use for over 40 years.


Chemical Structure

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Clonidine
CAS# 4205-90-7 (free base)

Theoretical Analysis

MedKoo Cat#: 317555
Name: Clonidine
CAS#: 4205-90-7 (free base)
Chemical Formula: C9H9Cl2N3
Exact Mass: 229.01735
Molecular Weight: 230.09
Elemental Analysis: C, 46.98; H, 3.94; Cl, 30.82; N, 18.26

Price and Availability

Size Price Availability Quantity
200.0mg USD 650.0 2 Weeks
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Related CAS #: 4205-90-7 (free base)   4205-91-8 (HCl)    

Synonym: Clonidine; Clonidin; Duraclon; Catapresan; Catapressan; Catapres-TTS; Catapres; Kapvay; Nexiclon; Clophelin

IUPAC/Chemical Name: N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine

InChi Key: GJSURZIOUXUGAL-UHFFFAOYSA-N

InChi Code: InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)

SMILES Code: C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl

Appearance: White to off-white crystalline powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 230.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jellinge ME, Petersen RH. [Clonidine can reduce opioid medication during post-operative pain]. Ugeskr Laeger. 2015 Nov 30;177(49). pii: V05150415. Danish. PubMed PMID: 26651552.

2: Braga MA, Martini MF, Pickholz M, Yokaichiya F, Franco MK, Cabeça LF, Guilherme VA, Silva CM, Limia CE, de Paula E. Clonidine complexation with hydroxypropyl-beta-cyclodextrin: From physico-chemical characterization to in vivo adjuvant effect in local anesthesia. J Pharm Biomed Anal. 2015 Nov 18;119:27-36. doi: 10.1016/j.jpba.2015.11.015. [Epub ahead of print] PubMed PMID: 26637952.

3: Taguchi K, Hida M, Matsumoto T, Kobayashi T. Resveratrol Ameliorates Clonidine-Induced Endothelium-Dependent Relaxation Involving Akt and Endothelial Nitric Oxide Synthase Regulation in Type 2 Diabetic Mice. Biol Pharm Bull. 2015;38(12):1864-72. doi: 10.1248/bpb.b15-00403. PubMed PMID: 26632178.

4: Al Khalifah R, Moisan L, Bui H. The shortened combined clonidine and arginine test for growth hormone deficiency is practical and specific: a diagnostic accuracy study. J Pediatr Endocrinol Metab. 2015 Dec 2. pii: /j/jpem.ahead-of-print/jpem-2015-0284/jpem-2015-0284.xml. doi: 10.1515/jpem-2015-0284. [Epub ahead of print] PubMed PMID: 26630691.

5: Majumdar S, Das A, Das H, Bandyopadhyay S, Hajra BK, Mukherjee D. Comparative evaluation of oral gabapentin versus clonidine as premedication on preoperative sedation and laryngoscopic stress response attenuation for the patients undergoing general anesthesia. Perspect Clin Res. 2015 Oct-Dec;6(4):211-6. doi: 10.4103/2229-3485.167094. PubMed PMID: 26623393; PubMed Central PMCID: PMC4640015.

6: Jiao F, Zhang X, Zhang X, Wang J. Clinical observation on treatment of Tourette syndrome in Chinese children by clonidine adhesive patch. Eur J Paediatr Neurol. 2015 Oct 22. pii: S1090-3798(15)00176-2. doi: 10.1016/j.ejpn.2015.10.002. [Epub ahead of print] PubMed PMID: 26602699.

7: Russo MA, Santarelli DM. A Novel Compound Analgesic Cream (Ketamine, Pentoxifylline, Clonidine, DMSO) for Complex Regional Pain Syndrome Patients. Pain Pract. 2015 Nov 7. doi: 10.1111/papr.12404. [Epub ahead of print] PubMed PMID: 26547813.

8: Arunkumar S, Hemanth Kumar VR, Krishnaveni N, Ravishankar M, Jaya V, Aruloli M. Comparison of dexmedetomidine and clonidine as an adjuvant to ropivacaine for epidural anesthesia in lower abdominal and lower limb surgeries. Saudi J Anaesth. 2015 Oct-Dec;9(4):404-8. doi: 10.4103/1658-354X.159464. PubMed PMID: 26543457; PubMed Central PMCID: PMC4610084.

9: Jing Wang G, Belley-Coté E, Burry L, Duffett M, Karachi T, Perri D, Alhazzani W, D'Aragon F, Wunsch H, Rochwerg B. Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol). Syst Rev. 2015 Nov 6;4:154. doi: 10.1186/s13643-015-0139-7. PubMed PMID: 26542363; PubMed Central PMCID: PMC4635616.

10: Zhang C, Li C, Pirrone M, Sun L, Mi W. Comparison of dexmedetomidine and clonidine as adjuvants to local anesthetics for intrathecal anesthesia: A meta-analysis of randomized controlled trials. J Clin Pharmacol. 2015 Oct 28. doi: 10.1002/jcph.666. [Epub ahead of print] PubMed PMID: 26510095.

Clonidine

200.0mg / USD 650.0