Clofibrate
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317552

CAS#: 637-07-0

Description: Clofibrate (Atromid-S) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity. It is marketed as a fibrate. It is a lipid-lowering agent used for controlling the high cholesterol and triacylglyceride level in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, and hence reduce the level of VLDL. It can increase the level of HDL as well.


Chemical Structure

img
Clofibrate
CAS# 637-07-0

Theoretical Analysis

MedKoo Cat#: 317552
Name: Clofibrate
CAS#: 637-07-0
Chemical Formula: C12H15ClO3
Exact Mass: 242.07097
Molecular Weight: 242.7
Elemental Analysis: C, 59.39; H, 6.23; Cl, 14.61; O, 19.78

Size Price Shipping out time Quantity
1g USD 150 2 Weeks
2g USD 190 2 Weeks
5g USD 250 2 Weeks
10g USD 350 2 Weeks
20g USD 450 2 Weeks
50g USD 650 2 Weeks
100g USD 850 2 Weeks
200g USD 1250 2 Weeks
500g USD 2150 2 Weeks
1kg USD 3150 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-25. Prices are subject to change without notice.

Clofibrate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: Clofibrate; Ethyl clofibrate; Atromid-S; Clofibrato; Clofibratum;

IUPAC/Chemical Name: ethyl 2-(4-chlorophenoxy)-2-methylpropanoate

InChi Key: KNHUKKLJHYUCFP-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3

SMILES Code: CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl

Appearance:
Colorless to light yellow liquid.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Light sensitive.

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 242.7 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Chandran K, Goswami S, Sharma-Walia N. Implications of a peroxisome proliferator-activated receptor alpha (PPARα) ligand clofibrate in breast cancer. Oncotarget. 2015 Nov 26. doi: 10.18632/oncotarget.6402. [Epub ahead of print] PubMed PMID: 26621841.

2: Takayanagi T, Takashima R, Wako Y, Kawasako K, Tanaka Y, Hori H, Fujii W. Repeated dose liver micronucleus assay using clofibrate in young adult rats. Mutat Res Genet Toxicol Environ Mutagen. 2015 Mar;780-781:117-22. doi: 10.1016/j.mrgentox.2015.01.002. Epub 2015 Jan 6. PubMed PMID: 25892631.

3: Gessner DK, Gröne B, Rosenbaum S, Most E, Hillen S, Becker S, Erhardt G, Reiner G, Eder K. Treatment of lactating sows with clofibrate as a synthetic agonist of PPARα does not influence milk fat content and gains of litters. BMC Vet Res. 2015 Mar 7;11:54. doi: 10.1186/s12917-015-0368-y. PubMed PMID: 25888880; PubMed Central PMCID: PMC4355968.

4: Lin X, Jacobi S, Odle J. Transplacental induction of fatty acid oxidation in term fetal pigs by the peroxisome proliferator-activated receptor alpha agonist clofibrate. J Anim Sci Biotechnol. 2015 Mar 26;6(1):11. doi: 10.1186/s40104-015-0010-7. eCollection 2015. PubMed PMID: 25883783; PubMed Central PMCID: PMC4399351.

5: Bai X, Lin X, Drayton J, Liu Y, Ji C, Odle J. Clofibrate increases long-chain fatty acid oxidation by neonatal pigs. J Nutr. 2014 Nov;144(11):1688-93. doi: 10.3945/jn.114.193169. Epub 2014 Sep 3. PubMed PMID: 25332467.

6: Guo X, Liang XF, Fang L, Yuan X, Zhou Y, He S, Shen D. Effects of lipid-lowering pharmaceutical clofibrate on lipid and lipoprotein metabolism of grass carp (Ctenopharyngodon idellal Val.) fed with the high non-protein energy diets. Fish Physiol Biochem. 2015 Apr;41(2):331-43. doi: 10.1007/s10695-014-9986-8. Epub 2014 Sep 12. PubMed PMID: 25213789.

7: Nafisi S, Heidari R, Ghaffarzadeh M, Ziaee M, Hamzeiy H, Garjani A, Eghbal MA. Cytoprotective effects of silafibrate, a newly-synthesised siliconated derivative of clofibrate, against acetaminophen-induced toxicity in isolated rat hepatocytes. Arh Hig Rada Toksikol. 2014 Jun;65(2):169-78. doi: 10.2478/10004-1254-65-2014-2434. PubMed PMID: 24706421.

8: Fukaya M, Kimata H. Topical clofibrate improves symptoms in patients with atopic dermatitis and reduces serum TARC levels: a randomized, double-blind, placebo-controlled pilot study. J Drugs Dermatol. 2014 Mar;13(3):259-63. PubMed PMID: 24595568.

9: Yousefipour Z, Newaz M. PPARα ligand clofibrate ameliorates blood pressure and vascular reactivity in spontaneously hypertensive rats. Acta Pharmacol Sin. 2014 Apr;35(4):476-82. doi: 10.1038/aps.2013.193. Epub 2014 Feb 24. PubMed PMID: 24562305.

10: Eghbalian F, Monsef F, Alam Ghomi N, Monsef A. Effect of Low versus Moderate Dose of Clofibrate on Serum Bilirubin in Healthy Term Neonates with Indirect Hyperbilirubinemia. Iran J Med Sci. 2013 Dec;38(4):349-50. PubMed PMID: 24293792; PubMed Central PMCID: PMC3838990.