MF-63
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522527

CAS#: 892549-43-8

Description: MF-63 is a novel and selective mPGES-1 inhibitor. MF63 potently inhibited the human mPGES-1 enzyme (IC(50) = 1.3 nM), with a high degree (>1000-fold) of selectivity over other prostanoid synthases. In rodent species, MF63 strongly inhibited guinea pig mPGES-1 (IC(50) = 0.9 nM) but not the mouse or rat enzyme. MF63 did not cause NSAID-like gastrointestinal toxic effects, such as mucosal erosions or leakage in the KI mice or nonhuman primates, although it markedly inhibited PGE(2) synthesis in the KI mouse stomach.


Chemical Structure

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MF-63
CAS# 892549-43-8

Theoretical Analysis

MedKoo Cat#: 522527
Name: MF-63
CAS#: 892549-43-8
Chemical Formula: C23H11ClN4
Exact Mass: 378.0672
Molecular Weight: 378.82
Elemental Analysis: C, 72.92; H, 2.93; Cl, 9.36; N, 14.79

Size Price Shipping out time Quantity
5mg USD 240 2 Weeks
10mg USD 310 2 Weeks
50mg USD 1140 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-07. Prices are subject to change without notice.

MF-63, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: MF-63; MF63; MF 63

IUPAC/Chemical Name: 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile

InChi Key: BVFLHOOKHPFDCT-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H11ClN4/c24-15-8-9-18-19(10-15)16-6-1-2-7-17(16)21-22(18)28-23(27-21)20-13(11-25)4-3-5-14(20)12-26/h1-10H,(H,27,28)

SMILES Code: N#CC1=CC=CC(C#N)=C1C2=NC3=C4C=CC(Cl)=CC4=C5C=CC=CC5=C3N2

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 378.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Xu D, Rowland SE, Clark P, Giroux A, Côté B, Guiral S, Salem M, Ducharme Y,
Friesen RW, Méthot N, Mancini J, Audoly L, Riendeau D. MF63
[2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective
microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in
preclinical models of inflammation. J Pharmacol Exp Ther. 2008 Sep;326(3):754-63.
doi: 10.1124/jpet.108.138776. Epub 2008 Jun 4. PubMed PMID: 18524979.



Additional Information

Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal prostaglandin E(2) (PGE(2)) synthase in the cyclooxygenase pathway. Inhibitors of mPGES-1 may block PGE(2) production and relieve inflammatory symptoms.