Aprindine HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317198

CAS#: 33237-74-0 (HCl)

Description: Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given orally.

Chemical Structure

Aprindine HCl
CAS# 33237-74-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 317198
Name: Aprindine HCl
CAS#: 33237-74-0 (HCl)
Chemical Formula: C22H31ClN2
Exact Mass:
Molecular Weight: 358.95
Elemental Analysis: C, 73.61; H, 8.71; Cl, 9.88; N, 7.80

Price and Availability

Size Price Availability Quantity
10.0mg USD 325.0 2 Weeks
50.0mg USD 1035.0 2 Weeks
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Related CAS #: 33237-74-0 (HCl)   37640-71-4 (free base)    

Synonym: Amidonal; Fiboran; Aprindin; Aprinidine; Fibocil; Aprindina; Aprindinum.

IUPAC/Chemical Name: N-(2,3-Dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-1,3-propanediamine hydrochloride


InChi Code: InChI=1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 358.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ozawa M, Komatsu T, Sato Y, Kunugita F, Tachibana H, Tashiro A, Okabayashi H, Nakamura M. Comparison of the effects of bepridil and aprindine for the prevention of atrial fibrillation after cardiac and aortic surgery: A prospective randomized study. J Arrhythm. 2015 Oct;31(5):302-6. doi: 10.1016/j.joa.2015.04.003. Epub 2015 May 16. PubMed PMID: 26550087; PubMed Central PMCID: PMC4600894.

2: Nakatani Y, Sakamoto T, Nishida K, Kataoka N, Yamaguchi Y, Sakabe M, Fujiki A, Mizumaki K, Inoue H. Bepridil enhances aprindine-induced prolongation of atrial effective refractory period in a canine atrial rapid pacing model. J Cardiol. 2015 Nov;66(5):445-50. doi: 10.1016/j.jjcc.2015.06.001. Epub 2015 Jul 7. PubMed PMID: 26162947.

3: Tsuchishita Y, Fukumoto K, Kusumoto M, Ueno K. Relationship between serum aprindine concentration and neurologic side effects in Japanese. Biol Pharm Bull. 2009 Apr;32(4):637-9. PubMed PMID: 19336897.

4: Nogami Y, Takase B, Matsui T, Hattori H, Hamabe A, Fujita M, Ohsuzu F, Ishihara M, Maekara T. Effect of antiarrhythmic agents on heart rate variability indices after myocardial infarction: comparative experimental study of aprindine and procainamide. Biomed Pharmacother. 2005 Oct;59 Suppl 1:S169-73. PubMed PMID: 16275488.

5: Tanaka H, Miake J, Notsu T, Sonyama K, Sasaki N, Iitsuka K, Kato M, Taniguchi S, Igawa O, Yoshida A, Shigemasa C, Hoshikawa Y, Kurata Y, Kuniyasu A, Nakayama H, Inagaki N, Nanba E, Shiota G, Morisaki T, Ninomiya H, Kitakaze M, Hisatome I. Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na+ channel blocker aprindine. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1001-6. PubMed PMID: 15882977.

6: Shimizu M, Ohota T, Kishida M, Ogata H. Nonlinear pharmacokinetics of aprindine in guinea pigs. Drug Metab Pharmacokinet. 2002;17(4):292-9. PubMed PMID: 15618680.

7: Fujiki A, Sakabe M, Nishida K, Sugao M, Tsuneda T, Iwamoto J, Mizumaki K, Inoue H. Drug-induced changes in fibrillation cycle length and organization index can predict chemical cardioversion of long-lasting atrial fibrillation with bepridil alone or in combination with aprindine. Circ J. 2004 Dec;68(12):1139-45. PubMed PMID: 15564697.

8: Fujiki A, Tsuneda T, Sakabe M, Nakagawa K, Mizumaki K, Hirai T, Inoue H. Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation. Circ J. 2004 Sep;68(9):834-9. PubMed PMID: 15329504.

9: Komatsu T, Nakamura S, Suzuki O, Yomogida K, Horiuchi D, Abe N, Kameda K, Owada S, Tomita H, Oikawa K, Okumura K. [Comparison of the efficacies of disopyramide, cibenzoline and aprindine for the termination of paroxysmal and persistent atrial fibrillation in elderly and non-elderly patients]. J Cardiol. 2003 Apr;41(4):191-8. Japanese. PubMed PMID: 12728540.

10: Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H; Sinus Rhythm Maintenance in Atrial Fibrillation Randomized Trial (SMART) Investigators. Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation. Circ J. 2002 Jun;66(6):553-6. PubMed PMID: 12074271.