Chlorhexidine Gluconate
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MedKoo CAT#: 317505

CAS#: 18472-51-0 (gluconate)

Description: Chlorhexidine digluconate solution is a bis-biguanide family cationic broad spectrum antibiotic. Studies indicate that chlorhexidine digluconate solution functions, via destabilization of the outer bacterial membrane, which resulted in the release of periplasmic enzymes in gram negative bacteria. In addition, Chlorhexidine digluconate solution inhibits oxygen utilization which leads to a reduction in bacterial ATP. Furthermore, Chlorhexidine digluconate solution is very effective against bacteria such as Propionibacterium, Selenomonas, and cocci resembling Veillonella.


Chemical Structure

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Chlorhexidine Gluconate
CAS# 18472-51-0 (gluconate)

Theoretical Analysis

MedKoo Cat#: 317505
Name: Chlorhexidine Gluconate
CAS#: 18472-51-0 (gluconate)
Chemical Formula: 34H54Cl2N10O14
Exact Mass:
Molecular Weight: 897.762
Elemental Analysis: C, 45.49; H, 6.06; Cl, 7.90; N, 15.60; O, 24.95

Price and Availability

Size Price Availability Quantity
1.0g USD 150.0 2 Weeks
2.0g USD 250.0 2 Weeks
5.0g USD 450.0 2 Weeks
20.0g USD 950.0 2 Weeks
100.0g USD 1450.0 2 Weeks
800.0g USD 2950.0 2 Weeks
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Related CAS #: 77146-42-0 (phosphanilate)   3697-42-5 (HCl)   18472-51-0 (gluconate)   55-56-1 (free base)  

Synonym: Chlorhexidine Gluconate; Chlorhexidine digluconate; Unisept; Peridex; 18472-51-0; UNII-MOR84MUD8E; Gibitan; Hexidine; Hibiclens; Hibident; Hibiscrub; Hibisol; Hibitane; Peridex; Perio Chip;

IUPAC/Chemical Name: 1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] Digluconate

InChi Key: YZIYKJHYYHPJIB-UUPCJSQJSA-N

InChi Code: InChI=1S/C22H30Cl2N10.2C6H12O7/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*7-1-2(8)3(9)4(10)5(11)6(12)13/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*2-5,7-11H,1H2,(H,12,13)/t;2*2-,3-,4+,5-/m.11/s1

SMILES Code: N=C(NC(NC1=CC=C(Cl)C=C1)=N)NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C(O)=O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 897.762 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bibi S, Shah SA, Qureshi S, Siddiqui TR, Soomro IA, Ahmed W, Alam SE. Is
chlorhexidine-gluconate superior than Povidone-Iodine in preventing surgical site
infections? A multicenter study. J Pak Med Assoc. 2015 Nov;65(11):1197-201.
PubMed PMID: 26564292.

2: Edmiston CE Jr, Lee CJ, Krepel CJ, Spencer M, Leaper D, Brown KR, Lewis BD,
Rossi PJ, Malinowski MJ, Seabrook GR. Evidence for a Standardized Preadmission
Showering Regimen to Achieve Maximal Antiseptic Skin Surface Concentrations of
Chlorhexidine Gluconate, 4%, in Surgical Patients. JAMA Surg. 2015 Nov
1;150(11):1027-33. doi: 10.1001/jamasurg.2015.2210. PubMed PMID: 26308490.

3: Srinivas A, Kaman L, Raj P, Gautam V, Dahiya D, Singh G, Singh R, Medhi B.
Comparison of the efficacy of chlorhexidine gluconate versus povidone iodine as
preoperative skin preparation for the prevention of surgical site infections in
clean-contaminated upper abdominal surgeries. Surg Today. 2015
Nov;45(11):1378-84. doi: 10.1007/s00595-014-1078-y. Epub 2014 Nov 9. PubMed PMID:
25381486.

4: Aqeel Y, Siddiqui R, Anwar A, Shah MR, Khan NA. Gold nanoparticle conjugation
enhanced anti-Acanthamoebic effects of chlorhexidine gluconate. Antimicrob Agents
Chemother. 2015 Dec 14. pii: AAC.01123-15. [Epub ahead of print] PubMed PMID:
26666949.

5: Shah HN, Schwartz JL, Luna G, Cullen DL. Bathing With 2% Chlorhexidine
Gluconate: Evidence and Costs Associated With Central Line-Associated Bloodstream
Infections. Crit Care Nurs Q. 2016 Jan-Mar;39(1):42-50. doi:
10.1097/CNQ.0000000000000096. PubMed PMID: 26633158.

6: Alawadi ZM, Kao LS. Chlorhexidine Gluconate, 4%, Showers and Surgical Site
Infection Reduction. JAMA Surg. 2015 Nov 1;150(11):1033. doi:
10.1001/jamasurg.2015.2219. PubMed PMID: 26308068.

7: Smith DC, Maiman R, Schwechter EM, Kim SJ, Hirsh DM. Optimal Irrigation and
Debridement of Infected Total Joint Implants with Chlorhexidine Gluconate. J
Arthroplasty. 2015 Oct;30(10):1820-2. doi: 10.1016/j.arth.2015.05.005. Epub 2015
May 15. PubMed PMID: 26105616.

8: Goel A, Sinha A, Khandeparker RV, Mehrotra R, Vashisth P, Garg A. Bioactive
Glass S53P4 versus Chlorhexidine Gluconate as Intracanal Medicament in Primary
Teeth: An In-vivo Study Using Polymerase Chain Reaction Analysis. J Int Oral
Health. 2015 Aug;7(8):65-9. PubMed PMID: 26464542; PubMed Central PMCID:
PMC4588793.

9: Casey A, Itrakjy A, Birkett C, Clethro A, Bonser R, Graham T, Mascaro J,
Pagano D, Rooney S, Wilson I, Nightingale P, Crosby C, Elliott T. A comparison of
the efficacy of 70% v/v isopropyl alcohol with either 0.5% w/v or 2% w/v
chlorhexidine gluconate for skin preparation before harvest of the long saphenous
vein used in coronary artery bypass grafting. Am J Infect Control. 2015
Aug;43(8):816-20. doi: 10.1016/j.ajic.2015.03.034. Epub 2015 May 13. PubMed PMID:
25979197.

10: Dalgleish L, Jhattu H, Gomersall JS. Daily 2% chlorhexidine gluconate bath
wash in a tertiary adult intensive care and high dependency units to reduce risk
of hospital acquired multi resistant organisms: a best practice implementation
project. JBI Database System Rev Implement Rep. 2015 Jul 17;13(6):434-48. doi:
10.11124/jbisrir-2015-2206. PubMed PMID: 26455757.

11: Yadav NS, Saraf S, Mishra SK, Hazari P. Effects of fluconazole, chlorhexidine
gluconate, and silver-zinc zeolite on flexural strength of heat-cured polymethyl
methacrylate resin. J Nat Sci Biol Med. 2015 Jul-Dec;6(2):340-2. doi:
10.4103/0976-9668.159999. PubMed PMID: 26283825; PubMed Central PMCID:
PMC4518405.

12: Davids BI, Davidson MJ, TenBroeck SH, Colahan PT, Oli MW. Efficacy of
Mechanical versus Non-Mechanical Sterile Preoperative Skin Preparation With
Chlorhexidine Gluconate 4% Solution. Vet Surg. 2015 Jul;44(5):648-52. doi:
10.1111/vsu.12335. Epub 2015 Apr 24. PubMed PMID: 25913145.

13: Prasad KA, John S, Deepika V, Dwijendra KS, Reddy BR, Chincholi S.
Anti-Plaque Efficacy of Herbal and 0.2% Chlorhexidine Gluconate Mouthwash: A
Comparative Study. J Int Oral Health. 2015 Aug;7(8):98-102. PubMed PMID:
26464549; PubMed Central PMCID: PMC4588801.

14: Kim JM, Ahn Y, LiPuma JJ, Hussong D, Cerniglia CE. Survival and
susceptibility of Burkholderia cepacia complex in chlorhexidine gluconate and
benzalkonium chloride. J Ind Microbiol Biotechnol. 2015 Jun;42(6):905-13. doi:
10.1007/s10295-015-1605-x. Epub 2015 Mar 21. PubMed PMID: 25794566.

15: Gupta D, Jain A. Effect of Cinnamon Extract and Chlorhexidine Gluconate
(0.2%) on the Clinical Level of Dental Plaque and Gingival Health: A 4-Week,
Triple-Blind Randomized Controlled Trial. J Int Acad Periodontol. 2015
Jul;17(3):91-8. PubMed PMID: 26373226.

16: Edmiston CE Jr, Assadian O, Spencer M, Olmsted RN, Barnes S, Leaper D. To
bathe or not to bathe with chlorhexidine gluconate: is it time to take a stand
for preadmission bathing and cleansing? AORN J. 2015 May;101(5):529-38. doi:
10.1016/j.aorn.2015.02.008. PubMed PMID: 25946179.

17: Chen W, Cao Q, Li S, Li H, Zhang W. Impact of daily bathing with
chlorhexidine gluconate on ventilator associated pneumonia in intensive care
units: a meta-analysis. J Thorac Dis. 2015 Apr;7(4):746-53. doi:
10.3978/j.issn.2072-1439.2015.04.21. PubMed PMID: 25973242; PubMed Central PMCID:
PMC4419331.

18: Hambire CU, Jawade R, Patil A, Wani VR, Kulkarni AA, Nehete PB. Comparing the
antiplaque efficacy of 0.5% Camellia sinensis extract, 0.05% sodium fluoride, and
0.2% chlorhexidine gluconate mouthwash in children. J Int Soc Prev Community
Dent. 2015 May-Jun;5(3):218-26. doi: 10.4103/2231-0762.158016. PubMed PMID:
26236682; PubMed Central PMCID: PMC4515805.

19: Shams WE, Hanley GA, Orvik A, Lewis N, Shurbaji MS. Peritoneal lavage using
chlorhexidine gluconate at the end of colon surgery reduces postoperative
intra-abdominal infection in mice. J Surg Res. 2015 May 1;195(1):121-7. doi:
10.1016/j.jss.2015.01.030. Epub 2015 Jan 22. PubMed PMID: 25687961.

20: Jones R, Hutton A, Mariyaselvam M, Hodges E, Wong K, Blunt M, Young P.
Keyboard cleanliness: a controlled study of the residual effect of chlorhexidine
gluconate. Am J Infect Control. 2015 Mar 1;43(3):289-91. doi:
10.1016/j.ajic.2014.12.002. PubMed PMID: 25728156.