WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319567
Description: Melogliptin, also known as EMD-675992 and GRC-8200, is a potent and selective a dipeptidyl peptidase IV (DPP-IV) inhibitor potentially for treatment of type II diabetes. Melogliptin significantly reduced HbA1c from baseline as compared to placebo with a mean average reduction of 0.75 percent in patients receiving 50mg twice daily dose and 0.60 percent in patients receiving 100 mg once daily dose.
MedKoo Cat#: 319567
Chemical Formula: C15H21FN6O
Exact Mass: 320.1761
Molecular Weight: 320.3724
Elemental Analysis: C, 56.24; H, 6.61; F, 5.93; N, 26.23; O, 4.99
Synonym: EMD-675992; EMD 675992; EMD675992; GRC-8200; GRC 8200; GRC8200; Melogliptin.
IUPAC/Chemical Name: 1-(((1R,3S)-3-((1H-1,2,4-triazol-1-yl)methyl)cyclopentyl)glycyl)-4-fluoropyrrolidine-2-carbonitrile
InChi Key: JSYGLDMGERSRPC-RJZJGCCBSA-N
InChi Code: InChI=1S/C15H21FN6O/c16-12-4-14(5-17)22(8-12)15(23)6-19-13-2-1-11(3-13)7-21-10-18-9-20-21/h9-14,19H,1-4,6-8H2/t11-,12?,13+,14?/m0/s1
SMILES Code: N#CC1N(C(CN[C@H]2C[C@@H](CN3N=CN=C3)CC2)=O)CC(F)C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 320.3724 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|