WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319567
Description: Melogliptin, also known as EMD-675992 and GRC-8200, is a potent and selective a dipeptidyl peptidase IV (DPP-IV) inhibitor potentially for treatment of type II diabetes. Melogliptin significantly reduced HbA1c from baseline as compared to placebo with a mean average reduction of 0.75 percent in patients receiving 50mg twice daily dose and 0.60 percent in patients receiving 100 mg once daily dose.
MedKoo Cat#: 319567
Chemical Formula: C15H21FN6O
Exact Mass: 320.1761
Molecular Weight: 320.3724
Elemental Analysis: C, 56.24; H, 6.61; F, 5.93; N, 26.23; O, 4.99
Melogliptin is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: EMD-675992; EMD 675992; EMD675992; GRC-8200; GRC 8200; GRC8200; Melogliptin.
IUPAC/Chemical Name: 1-(((1R,3S)-3-((1H-1,2,4-triazol-1-yl)methyl)cyclopentyl)glycyl)-4-fluoropyrrolidine-2-carbonitrile
InChi Key: JSYGLDMGERSRPC-RJZJGCCBSA-N
InChi Code: InChI=1S/C15H21FN6O/c16-12-4-14(5-17)22(8-12)15(23)6-19-13-2-1-11(3-13)7-21-10-18-9-20-21/h9-14,19H,1-4,6-8H2/t11-,12?,13+,14?/m0/s1
SMILES Code: N#CC1N(C(CN[C@H]2C[C@@H](CN3N=CN=C3)CC2)=O)CC(F)C1
The following data is based on the product molecular weight 320.3724 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|