Melogliptin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319567

CAS#: 868771-57-7

Description: Melogliptin, also known as EMD-675992 and GRC-8200, is a potent and selective a dipeptidyl peptidase IV (DPP-IV) inhibitor potentially for treatment of type II diabetes. Melogliptin significantly reduced HbA1c from baseline as compared to placebo with a mean average reduction of 0.75 percent in patients receiving 50mg twice daily dose and 0.60 percent in patients receiving 100 mg once daily dose.

Chemical Structure

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Melogliptin
CAS# 868771-57-7
Instruction

Theoretical Analysis

MedKoo Cat#: 319567
Name: Melogliptin
CAS#: 868771-57-7
Chemical Formula: C15H21FN6O
Exact Mass: 320.18
Molecular Weight: 320.372
Elemental Analysis: C, 56.24; H, 6.61; F, 5.93; N, 26.23; O, 4.99

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Synonym: EMD-675992; EMD 675992; EMD675992; GRC-8200; GRC 8200; GRC8200; Melogliptin.

IUPAC/Chemical Name: 1-(((1R,3S)-3-((1H-1,2,4-triazol-1-yl)methyl)cyclopentyl)glycyl)-4-fluoropyrrolidine-2-carbonitrile

InChi Key: JSYGLDMGERSRPC-RJZJGCCBSA-N

InChi Code: InChI=1S/C15H21FN6O/c16-12-4-14(5-17)22(8-12)15(23)6-19-13-2-1-11(3-13)7-21-10-18-9-20-21/h9-14,19H,1-4,6-8H2/t11-,12?,13+,14?/m0/s1

SMILES Code: N#CC1N(C(CN[C@H]2C[C@@H](CN3N=CN=C3)CC2)=O)CC(F)C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 320.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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