WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522524
Description: PF-4191834 is a novel, potent and selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. PF-4191834 exhibits good potency in enzyme- and cell-based assays, as well as in a rat model of acute inflammation. Enzyme assay results indicate that PF-4191834 is a potent 5-LOX inhibitor, with an IC(50) = 229 +/- 20 nM. Furthermore, it demonstrated approximately 300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and shows no activity toward the cyclooxygenase enzymes. In addition, PF-4191834 inhibits 5-LOX in human blood cells, with an IC(80) = 370 +/- 20 nM.
MedKoo Cat#: 522524
Chemical Formula: C22H23N3O2S
Exact Mass: 393.1511
Molecular Weight: 393.51
Elemental Analysis: C, 67.15; H, 5.89; N, 10.68; O, 8.13; S, 8.15
Synonym: PF-04191834; PF04191834; PF 04191834; PF-4191834; PF4191834; PF 4191834.
IUPAC/Chemical Name: 4-(3-((4-(1-methyl-1H-pyrazol-5-yl)phenyl)thio)phenyl)tetrahydro-2H-pyran-4-carboxamide
InChi Key: DVNQWYLVSNPCJZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H23N3O2S/c1-25-20(9-12-24-25)16-5-7-18(8-6-16)28-19-4-2-3-17(15-19)22(21(23)26)10-13-27-14-11-22/h2-9,12,15H,10-11,13-14H2,1H3,(H2,23,26)
SMILES Code: O=C(C1(C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)CCOCC1)N
1: Masferrer JL, Zweifel BS, Hardy M, Anderson GD, Dufield D, Cortes-Burgos L,
Pufahl RA, Graneto M. Pharmacology of PF-4191834, a novel, selective non-redox
5-lipoxygenase inhibitor effective in inflammation and pain. J Pharmacol Exp
Ther. 2010 Jul;334(1):294-301. doi: 10.1124/jpet.110.166967. Epub 2010 Apr 8.
PubMed PMID: 20378715.