WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522522

CAS#: 906673-33-4

Description: AN-2898 ia a potent and selective PDE4 inhibitor potentially for the treatment of fungal infection. AN2898 inhibited phosphodiesterase 4 (PDE4) enzyme activity (IC50 0.060 μM) and the release of multiple cytokines including TNF-α (IC50 0.16 μM) from peripheral blood mononuclear cells (hPBMCs) stimulated by lipopolysaccharide (LPS) or phytohemag- glutinin.

Chemical Structure

CAS# 906673-33-4

Theoretical Analysis

MedKoo Cat#: 522522
Name: AN-2898
CAS#: 906673-33-4
Chemical Formula: C15H9BN2O3
Exact Mass: 276.0706
Molecular Weight: 276.06
Elemental Analysis: C, 65.26; H, 3.29; B, 3.92; N, 10.15; O, 17.39

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Synonym: AN-2898; AN 2898; AN2898.

IUPAC/Chemical Name: 4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)phthalonitrile


InChi Code: InChI=1S/C15H9BN2O3/c17-7-10-1-2-13(5-11(10)8-18)21-14-3-4-15-12(6-14)9-20-16(15)19/h1-6,19H,9H2


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 276.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ciaravino V, Plattner J, Chanda S. An assessment of the genetic toxicology of
novel boron-containing therapeutic agents. Environ Mol Mutagen. 2013
Jun;54(5):338-46. doi: 10.1002/em.21779. Epub 2013 Apr 26. PubMed PMID: 23625818.