WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522522
Description: AN-2898 ia a potent and selective PDE4 inhibitor potentially for the treatment of fungal infection. AN2898 inhibited phosphodiesterase 4 (PDE4) enzyme activity (IC50 0.060 μM) and the release of multiple cytokines including TNF-α (IC50 0.16 μM) from peripheral blood mononuclear cells (hPBMCs) stimulated by lipopolysaccharide (LPS) or phytohemag- glutinin.
MedKoo Cat#: 522522
Chemical Formula: C15H9BN2O3
Exact Mass: 276.0706
Molecular Weight: 276.06
Elemental Analysis: C, 65.26; H, 3.29; B, 3.92; N, 10.15; O, 17.39
AN-2898, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
Synonym: AN-2898; AN 2898; AN2898.
IUPAC/Chemical Name: 4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)phthalonitrile
InChi Key: UBMGTTRDNUKZMT-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H9BN2O3/c17-7-10-1-2-13(5-11(10)8-18)21-14-3-4-15-12(6-14)9-20-16(15)19/h1-6,19H,9H2
SMILES Code: N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1C#N
The following data is based on the product molecular weight 276.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ciaravino V, Plattner J, Chanda S. An assessment of the genetic toxicology of
novel boron-containing therapeutic agents. Environ Mol Mutagen. 2013
Jun;54(5):338-46. doi: 10.1002/em.21779. Epub 2013 Apr 26. PubMed PMID: 23625818.