AN-2898

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522522

CAS#: 906673-33-4

Description: AN-2898 ia a potent and selective PDE4 inhibitor potentially for the treatment of fungal infection. AN2898 inhibited phosphodiesterase 4 (PDE4) enzyme activity (IC50 0.060 μM) and the release of multiple cytokines including TNF-α (IC50 0.16 μM) from peripheral blood mononuclear cells (hPBMCs) stimulated by lipopolysaccharide (LPS) or phytohemag- glutinin.


Chemical Structure

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AN-2898
CAS# 906673-33-4

Theoretical Analysis

MedKoo Cat#: 522522
Name: AN-2898
CAS#: 906673-33-4
Chemical Formula: C15H9BN2O3
Exact Mass: 276.0706
Molecular Weight: 276.06
Elemental Analysis: C, 65.26; H, 3.29; B, 3.92; N, 10.15; O, 17.39

Size Price Shipping out time Quantity
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Pricing updated 2021-03-08. Prices are subject to change without notice.

AN-2898, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Synonym: AN-2898; AN 2898; AN2898.

IUPAC/Chemical Name: 4-((1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)phthalonitrile

InChi Key: UBMGTTRDNUKZMT-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H9BN2O3/c17-7-10-1-2-13(5-11(10)8-18)21-14-3-4-15-12(6-14)9-20-16(15)19/h1-6,19H,9H2

SMILES Code: N#CC1=CC=C(OC2=CC=C(B(O)OC3)C3=C2)C=C1C#N

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 276.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ciaravino V, Plattner J, Chanda S. An assessment of the genetic toxicology of
novel boron-containing therapeutic agents. Environ Mol Mutagen. 2013
Jun;54(5):338-46. doi: 10.1002/em.21779. Epub 2013 Apr 26. PubMed PMID: 23625818.