Cetirizine Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317500

CAS#: 83881-52-1 (HCl)

Description: Cetirizine hydrochloride is a potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Cetirizine hydrochloride is a carboxylated metabolite of hydroxyzine that acts as a selective Histamine H1 receptor inverse agonist. Compared to its parent compound, it shows similar antihistaminic activity, but with greater H1 selectivity and less sedative effects.

Chemical Structure

Cetirizine Hydrochloride
CAS# 83881-52-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 317500
Name: Cetirizine Hydrochloride
CAS#: 83881-52-1 (HCl)
Chemical Formula: C21H27Cl3N2O3
Exact Mass:
Molecular Weight: 461.81
Elemental Analysis: C, 54.62; H, 5.89; Cl, 23.03; N, 6.07; O, 10.39

Price and Availability

Size Price Availability Quantity
1.0g USD 90.0 Same day
2.0g USD 150.0 Same day
5.0g USD 250.0 2 weeks
10.0g USD 450.0 2 weeks
20.0g USD 750.0 2 weeks
50.0g USD 1250.0 2 weeks
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Related CAS #: 83881-51-0 (free base)   83881-52-1 (HCl)    

Synonym: Cetirizine Hydrochloride; 83881-52-1; Reactine; Zyrtec; CETIRIZINE HYDROCHLORIDE; Alerlisin; Aliud Brand of Cetirizine Dihydrochloride; Alpharma Brand of Cetirizine Dihydrochloride; AWD.pharma Brand of Cetirizine Dihydrochloride; Azupharma Brand of Cetirizine Dihydrochloride; Basics Brand of Cetirizine Dihydrochloride;

IUPAC/Chemical Name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride


InChi Code: InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 461.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Preis M, Grother L, Axe P, Breitkreutz J. In-vitro and in-vivo evaluation of
taste-masked cetirizine hydrochloride formulated in oral lyophilisates. Int J
Pharm. 2015 Aug 1;491(1-2):8-16. doi: 10.1016/j.ijpharm.2015.06.002. Epub 2015
Jun 5. PubMed PMID: 26051543.

2: Sharma D, Singh G, Kumar D, Singh M. Formulation development and evaluation of
fast disintegrating tablets of salbutamol sulphate, cetirizine hydrochloride in
combined pharmaceutical dosage form: a new era in novel drug delivery for
pediatrics and geriatrics. J Drug Deliv. 2015;2015:640529. doi:
10.1155/2015/640529. Epub 2015 Feb 25. PubMed PMID: 25810924; PubMed Central
PMCID: PMC4355560.

3: El-Say KM, El-Helw AR, Ahmed OA, Hosny KM, Ahmed TA, Kharshoum RM, Fahmy UA,
Alsawahli M. Statistical optimization of controlled release microspheres
containing cetirizine hydrochloride as a model for water soluble drugs. Pharm Dev
Technol. 2015;20(6):738-46. doi: 10.3109/10837450.2014.920353. Epub 2014 May 26.
PubMed PMID: 24856961.

4: Sharma D, Singh M, Kumar D, Singh G. Formulation Development and Evaluation of
Fast Disintegrating Tablet of Cetirizine Hydrochloride: A Novel Drug Delivery for
Pediatrics and Geriatrics. J Pharm (Cairo). 2014;2014:808167. doi:
10.1155/2014/808167. Epub 2014 Feb 18. PubMed PMID: 26556203; PubMed Central
PMCID: PMC4590798.

5: Wildermuth K, Zabel S, Rosychuk RA. The efficacy of cetirizine hydrochloride
on the pruritus of cats with atopic dermatitis: a randomized, double-blind,
placebo-controlled, crossover study. Vet Dermatol. 2013 Dec;24(6):576-81, e137-8.
doi: 10.1111/vde.12067. Epub 2013 Sep 20. PubMed PMID: 24112588.

6: Tsunemi Y, Saeki H, Tamaki K, Sato S, Nakamura K. Cetirizine hydrochloride
suppresses the CCL17 production of epidermal keratinocytes and dermal
fibroblasts. Int J Dermatol. 2012 Aug;51(8):1003-5. doi:
10.1111/j.1365-4632.2010.04708.x. PubMed PMID: 22788822.

7: Griffin JS, Scott DW, Miller WH Jr, Tranchina MM. An open clinical trial on
the efficacy of cetirizine hydrochloride in the management of allergic pruritus
in cats. Can Vet J. 2012 Jan;53(1):47-50. PubMed PMID: 22753962; PubMed Central
PMCID: PMC3239147.

8: Trivedi RK, Patel MC, Jadhav SB. A Rapid, Stability Indicating RP-UPLC Method
for Simultaneous Determination of Ambroxol Hydrochloride, Cetirizine
Hydrochloride and Antimicrobial Preservatives in Liquid Pharmaceutical
Formulation. Sci Pharm. 2011 Sep;79(3):525-43. doi: 10.3797/scipharm.1103-19.
Epub 2011 May 26. PubMed PMID: 21886901; PubMed Central PMCID: PMC3163363.

9: Okubo Y, Shigoka Y, Yamazaki M, Tsuboi R. Double dose of cetirizine
hydrochloride is effective for patients with urticaria resistant: a prospective,
randomized, non-blinded, comparative clinical study and assessment of quality of
life. J Dermatolog Treat. 2013 Apr;24(2):153-60. doi:
10.3109/09546634.2011.608783. Epub 2011 Aug 24. PubMed PMID: 21810005.

10: Sun Y, Jiang Y, An K. Preparation and the influencing factors of cetirizine
hydrochloride microemulsion. Artif Cells Blood Substit Immobil Biotechnol. 2011
Jun;39(3):174-6. doi: 10.3109/10731199.2010.525710. Epub 2010 Oct 15. PubMed
PMID: 20946090.

11: Xu FG, Liu Y, Zhang ZJ, Tian Y, Chen Y. Pharmacokinetics and bioequivalence
study of two cetirizine hydrochloride formulations in healthy Chinese male
volunteers. Arzneimittelforschung. 2009;59(9):440-4. doi: 10.1055/s-0031-1296422.
PubMed PMID: 19856790.

12: Tashiro M, Kato M, Miyake M, Watanuki S, Funaki Y, Ishikawa Y, Iwata R, Yanai
K. Dose dependency of brain histamine H(1) receptor occupancy following oral
administration of cetirizine hydrochloride measured using PET with [11C]doxepin.
Hum Psychopharmacol. 2009 Oct;24(7):540-8. doi: 10.1002/hup.1051. PubMed PMID:

13: Sugiura K, Hirai S, Suzuki T, Usuda T, Kondo T, Azumi T, Masaki S, Yokoi T,
Nitta Y, Kamiya S, Ando K, Mori T, Tomita Y. Evaluation of cetirizine
hydrochloride-based therapeutic strategy for chronic urticaria. Nagoya J Med Sci.
2008 Aug;70(3-4):97-106. PubMed PMID: 18954028.

14: Bhatia NM, Ganbavale SK, Bhatia MS, More HN, Kokil SU. RP-HPLC and
Spectrophotometric Estimation of Ambroxol Hydrochloride and Cetirizine
Hydrochloride in Combined Dosage Form. Indian J Pharm Sci. 2008 Sep;70(5):603-8.
doi: 10.4103/0250-474X.45398. PubMed PMID: 21394256; PubMed Central PMCID:

15: Liu JY, Zhao YZ, Peng C, Li FQ, Zhu QG, Hu JH. [Effect of cetirizine
hydrochloride on the expression of substance P receptor and cytokines production
in human epidermal keratinocytes and dermal fibroblasts]. Yao Xue Xue Bao. 2008
Apr;43(4):383-7. Chinese. PubMed PMID: 18664200.

16: Enomoto T, Ide T, Ogino S. Construction of an environmental exposure unit and
investigation of the effects of cetirizine hydrochloride on symptoms of cedar
pollinosis in Japan. J Investig Allergol Clin Immunol. 2007;17(3):173-81. PubMed
PMID: 17583105.

17: Gowekar NM, Pande VV, Kasture AV, Tekade AR, Chandorkar JG.
Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from
tablet dosage form. Pak J Pharm Sci. 2007 Jul;20(3):250-1. PubMed PMID: 17545112.

18: Liu JY, Hu JH, Zhu QG, Li FQ, Sun HJ. [Effect of cetirizine hydrochloride on
the expression of substance P in IgE-mediated triphasic cutaneous reaction]. Yao
Xue Xue Bao. 2005 Jul;40(7):649-53. Chinese. PubMed PMID: 16196274.

19: Ousler GW, Wilcox KA, Gupta G, Abelson MB. An evaluation of the ocular drying
effects of 2 systemic antihistamines: loratadine and cetirizine hydrochloride.
Ann Allergy Asthma Immunol. 2004 Nov;93(5):460-4. PubMed PMID: 15562885.

20: Li Q, Shen WB, Zou QG. [NMR studies on cetirizine hydrochloride]. Yao Xue Xue
Bao. 2003 Oct;38(10):767-70. Chinese. PubMed PMID: 14730901.