WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319555
CAS#: 1187856-49-0
Description: Ralinepag (APD-811) is an orally available agonist of the prostacyclin (IP) receptor intended for the treatment of vasospastic diseases such as Pulmonary Arterial Hypertension. Ralinepag has the potential to mimic prostacyclin -- the major product of cyclooxygenase -- in macrovascular endothelium This elicits a potent vasodilation response and inhibition of platelet aggregation when binding to this receptor.
MedKoo Cat#: 319555
Name: Ralinepag
CAS#: 1187856-49-0
Chemical Formula: C23H26ClNO5
Exact Mass: 431.15
Molecular Weight: 431.91
Elemental Analysis: C, 63.96; H, 6.07; Cl, 8.21; N, 3.24; O, 18.52
Synonym: APD-811; APD 811; APD811; Ralinepag
IUPAC/Chemical Name: 2-(((1r,4r)-4-((((4-chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetic acid
InChi Key: NPDKXVKJRHPDQT-IYARVYRRSA-N
InChi Code: InChI=1S/C23H26ClNO5/c24-19-10-12-21(13-11-19)25(20-4-2-1-3-5-20)23(28)30-15-18-8-6-17(7-9-18)14-29-16-22(26)27/h1-5,10-13,17-18H,6-9,14-16H2,(H,26,27)/t17-,18-
SMILES Code: O=C(O)COC[C@H]1CC[C@H](COC(N(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)=O)CC1
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 431.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Tran, T.-A., Kramer, B., Shin, Y.-J., et al. Discovery of 2-(((1r,4r)-4-(((4-chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralingepag): An orally active prostacyclin receptor agonist for the treatment of pulmonary arterial hypertension. J. Med. Chem. 60(3), 913-927 (2017).
