Cephalexin
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MedKoo CAT#: 317456

CAS#: 15686-71-2

Description: Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins on bacterial cell wall mucopeptide synthesis. Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins.

Chemical Structure

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Cephalexin
CAS# 15686-71-2
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 317456
Name: Cephalexin
CAS#: 15686-71-2
Chemical Formula: C16H17N3O4S
Exact Mass:
Molecular Weight: 347.89
Elemental Analysis: C, 55.32; H, 4.93; N, 12.10; O, 18.42; S, 9.23

Size Price Shipping out time Quantity
500mg USD 70 2 Weeks
1g USD 90 2 Weeks
2g USD 150 2 Weeks
5g USD 250 2 Weeks
10g USD 350 2 Weeks
20g USD 550 2 Weeks
50g USD 850 2 Weeks
100g USD 1450 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-03-08. Prices are subject to change without notice.

Cephalexin purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: Cephalexin; Cefalexin; Cephacillin; Ceporexin; Keflex; Celexin; Cephalexin Hemihydrate; Cephalexin Hydrochloride; Cephalexin Monohydrate; Cephalexin Monohydrochloride; Cephalexin Monohydrochloride, Monohydrate; Cephalexin, (6R-(6alpha,7alpha(R*)))-Isomer; Cephalexin, (6R-(6alpha,7beta(S*)))-Isomer; Cephalexin, (6R-(6alpha,7beta))-Isomer; Cephalexin, Monosodium Salt; Cephalexin, Monosodium Salt, (6R-(6alpha,7beta))-Isomer; Ceporexine; Dihydride, Cephalexin; Hemihydrate, Cephalexin; Hydrochloride, Cephalexin; Monohydrate Cephalexin Monohydrochloride; Monohydrate, Cephalexin; Monohydrochloride, Cephalexin; Monohydrochloride, Monohydrate Cephalexin; Monosodium Salt Cephalexin; Palitrex

IUPAC/Chemical Name: (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

InChi Key: ZAIPMKNFIOOWCQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)

SMILES Code: CC1=C(N2C(C(C2=O)NC(=O)C(C3=CC=CC=C3)N)SC1)C(=O)O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 347.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Pontremoli C, Barbero N, Viscardi G, Visentin S. Mucin-drugs interaction: The
case of theophylline, prednisolone and cephalexin. Bioorg Med Chem. 2015 Oct
15;23(20):6581-6. doi: 10.1016/j.bmc.2015.09.021. Epub 2015 Sep 15. PubMed PMID:
26422788.

2: Beloglazova NV, Eremin SA. Design of a sensitive fluorescent polarization
immunoassay for rapid screening of milk for cephalexin. Anal Bioanal Chem. 2015
Nov;407(28):8525-32. doi: 10.1007/s00216-015-9006-6. Epub 2015 Sep 28. PubMed
PMID: 26416019.

3: Singh PK, Prabhune A, Ogale S. Pulsed Laser-Driven Molecular Self-assembly of
Cephalexin: Aggregation-Induced Fluorescence and Its Utility as a Mercury Ion
Sensor. Photochem Photobiol. 2015 Nov;91(6):1340-7. doi: 10.1111/php.12526. Epub
2015 Oct 14. PubMed PMID: 26333412.

4: Patel R, Amber KT. Thrombotic thrombocytopenic purpura in a postoperative
patient taking cephalexin responding to plasmapheresis: A case report and review
of cephalosporin-induced TTP. J Clin Apher. 2015 Aug 14. doi: 10.1002/jca.21420.
[Epub ahead of print] PubMed PMID: 26274019.

5: Baradhi KM, Ahmed S, Buford ML. The Case | Acute renal failure after
antibiotic treatment for bronchitis. Diagnosis: Pigment nephropathy from
cephalexin-induced immune hemolytic anemia. Kidney Int. 2015 Jun;87(6):1269-70.
doi: 10.1038/ki.2014.152. PubMed PMID: 26024043.

6: Anacona JR, Rangel V, Loroño M, Camus J. Tetradentate metal complexes derived
from cephalexin and 2,6-diacetylpyridine bis(hydrazone): Synthesis,
characterization and antibacterial activity. Spectrochim Acta A Mol Biomol
Spectrosc. 2015 Oct 5;149:23-9. doi: 10.1016/j.saa.2015.04.054. Epub 2015 Apr 25.
PubMed PMID: 25942081.

7: Lata K, Sharma R, Naik L, Rajput YS, Mann B. Synthesis and application of
cephalexin imprinted polymer for solid phase extraction in milk. Food Chem. 2015
Oct 1;184:176-82. doi: 10.1016/j.foodchem.2015.03.101. Epub 2015 Mar 28. PubMed
PMID: 25872441.

8: Anacona JR, Rincones M. Tridentate hydrazone metal complexes derived from
cephalexin and 2-hydrazinopyridine: synthesis, characterization and antibacterial
activity. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Apr 15;141:169-75. doi:
10.1016/j.saa.2015.01.009. Epub 2015 Jan 31. PubMed PMID: 25677531.

9: Prados AP, Schaiquevich P, Kreil V, Monfrinotti A, Quaine P, Tarragona L,
Hallu R, Rebuelto M. A population pharmacokinetic approach to describe cephalexin
disposition in adult and aged dogs. Vet Med Int. 2014;2014:789353. doi:
10.1155/2014/789353. Epub 2014 Nov 6. PubMed PMID: 25431741; PubMed Central
PMCID: PMC4241252.

10: Agrawal A, Rao M, Jasdanwala S, Mathur A, Eng M. Cephalexin induced
cholestatic jaundice. Case Rep Gastrointest Med. 2014;2014:260743. doi:
10.1155/2014/260743. Epub 2014 Aug 7. PubMed PMID: 25180107; PubMed Central
PMCID: PMC4142286.

11: Kulapina OI, Vostrikova AM. [Rapid determination of cephalexin in biological
media]. Antibiot Khimioter. 2014;59(1-2):6-9. Russian. PubMed PMID: 25051709.

12: Ayazi P, Mahyar A, Taremiha A, Ghorani N, Esmailzadehha N. Effect of oral
cephalexin in the treatment of BCG lymphadenitis. Infez Med. 2014
Jun;22(2):112-7. PubMed PMID: 24955797.

13: Anacona JR, Rodriguez JL, Camus J. Synthesis, characterization and
antibacterial activity of a Schiff base derived from cephalexin and
sulphathiazole and its transition metal complexes. Spectrochim Acta A Mol Biomol
Spectrosc. 2014 Aug 14;129:96-102. doi: 10.1016/j.saa.2014.03.019. Epub 2014 Mar
27. PubMed PMID: 24727167.

14: Cunha BA. Cephalexin remains the preferred antibiotic for uncomplicated
cellulitis: revisited. J Chemother. 2014 Apr;26(2):65-6. doi:
10.1179/1973947814Y.0000000170. Epub 2014 Feb 18. PubMed PMID: 24548092.

15: Panda SS, Ravi Kumar BV, Dash R, Mohanta G. Determination of Cephalexin
Monohydrate in Pharmaceutical Dosage Form by Stability-Indicating RP-UFLC and UV
Spectroscopic Methods. Sci Pharm. 2013 Jul 31;81(4):1029-41. doi:
10.3797/scipharm.1306-07. eCollection 2013 Dec. PubMed PMID: 24482771; PubMed
Central PMCID: PMC3867238.

16: Bhaskara Rao BV, Mukherji R, Shitre G, Alam F, Prabhune AA, Kale SN.
Controlled release of antimicrobial Cephalexin drug from silica microparticles.
Mater Sci Eng C Mater Biol Appl. 2014 Jan 1;34:9-14. doi:
10.1016/j.msec.2013.10.002. Epub 2013 Oct 11. PubMed PMID: 24268227.

17: Chou YJ, Lee KY, Tsai MS, Sun HY, Hung CC. Use of cephalexin plus
trimethoprim/sulfamethoxazole vs cephalexin alone for treatment of uncomplicated
cellulitis. Clin Infect Dis. 2013 Oct;57(8):1216-7. doi: 10.1093/cid/cit449. Epub
2013 Jul 2. PubMed PMID: 23821731.

18: Autmizguine J, Watt KM, Théorêt Y, Kassir N, Laferrière C, Parent S, Tapiéro
B, Ovetchkine P. Pharmacokinetics and pharmacodynamics of oral cephalexin in
children with osteoarticular infections. Pediatr Infect Dis J. 2013
Dec;32(12):1340-4. doi: 10.1097/INF.0b013e3182a222a6. PubMed PMID: 23811740.

19: Liew KB, Peh KK, Loh GO, Tan YT. Three-ways crossover bioequivalence study of
cephalexin in healthy Malay volunteers. Drug Dev Ind Pharm. 2014
Sep;40(9):1156-62. doi: 10.3109/03639045.2013.798805. Epub 2013 May 20. PubMed
PMID: 23688276.

20: Yin L, Qin C, Chen K, Zhu C, Cao H, Zhou J, He W, Zhang Q. Gastro-floating
tablets of cephalexin: preparation and in vitro/in vivo evaluation. Int J Pharm.
2013 Aug 16;452(1-2):241-8. doi: 10.1016/j.ijpharm.2013.05.011. Epub 2013 May 13.
PubMed PMID: 23680730.

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Cephalexin

500mg / USD 70