Nelonicline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319554

CAS#: 1026134-63-3

Description: Nelonicline, aslo known as ABT-126, is an Alpha7 nicotinic acetylcholine receptor agonist and Nicotinic acetylcholine receptor agonist. Nelonicline is potentially useful for the treatment of Alzheimer's diseases. ABT-126 may be useful to reduce dyskinesias in both early- and later-stage Parkinson's disease. Accumulating evidence suggests that the α7 subtype of nicotinic acetylcholine receptors (nAChRs) plays a key role in inflammatory processes, thought to be involved in the pathophysiology of neuropsychiatric diseases, such as schizophrenia and Alzheimer's disease.


Chemical Structure

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Nelonicline
CAS# 1026134-63-3

Theoretical Analysis

MedKoo Cat#: 319554
Name: Nelonicline
CAS#: 1026134-63-3
Chemical Formula: C17H19N3OS
Exact Mass: 313.1249
Molecular Weight: 313.42
Elemental Analysis: C, 65.15; H, 6.11; N, 13.41; O, 5.10; S, 10.23

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Synonym: ABT-126; ABT126; ABT 126; Nelonicline

IUPAC/Chemical Name: 2-(((3R,4r,5S,7s)-1-azaadamantan-4-yl)oxy)-5-phenyl-1,3,4-thiadiazole

InChi Key: QZDCYUCETTWCMO-OFTMQHFLSA-N

InChi Code: InChI=1S/C17H19N3OS/c1-2-4-12(5-3-1)16-18-19-17(22-16)21-15-13-6-11-7-14(15)10-20(8-11)9-13/h1-5,11,13-15H,6-10H2/t11-,13-,14+,15+

SMILES Code: C1(C(S2)=NN=C2O[C@@H]3[C@H]4C[C@H]5C[C@@H]3CN(C4)C5)=CC=CC=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 313.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhang D, McGregor M, Bordia T, Perez XA, McIntosh JM, Decker MW, Quik M. α7
nicotinic receptor agonists reduce levodopa-induced dyskinesias with severe
nigrostriatal damage. Mov Disord. 2015 Nov 17. doi: 10.1002/mds.26453. [Epub
ahead of print] Review. PubMed PMID: 26573698.

2: Hashimoto K. Targeting of α7 Nicotinic Acetylcholine Receptors in the
Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a
Translational Biomarker. Curr Pharm Des. 2015;21(26):3797-806. PubMed PMID:
26044974.