Eleclazine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319545

CAS#: 1443211-72-0

Description: Eleclazine, also known as GS-6615, is a selective late sodium current inhibitor. Eleclazine is potentially useful for treatment of coronary vasodilators, antiarrhythmics and vasodilators. Eleclazin showed a shortening of the QTc interval (the time interval between the start of the Q-wave and end of the T-wave in the heart’s electrical cycle) in patients with long QT-3 (LQT3) syndrome. LQT3 is a genetic disorder that prolongs the heart’s QTc interval and can cause life-threatening cardiac arrhythmias (abnormal heartbeats).


Chemical Structure

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Eleclazine
CAS# 1443211-72-0

Theoretical Analysis

MedKoo Cat#: 319545
Name: Eleclazine
CAS#: 1443211-72-0
Chemical Formula: C21H16F3N3O3
Exact Mass: 415.1144
Molecular Weight: 415.37
Elemental Analysis: C, 60.72; H, 3.88; F, 13.72; N, 10.12; O, 11.56

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Synonym: GS-6615; GS 6615; GS6615; Eleclazine.

IUPAC/Chemical Name: 4-[(pyrimidin-2-yl)methyl]-7-[4-(trifluoromethoxy)phenyl]- 3,4-dihydro-1,4-benzoxazepin-5(2H)-one

InChi Key: YNUAEEJQYHYLMS-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H16F3N3O3/c22-21(23,24)30-16-5-2-14(3-6-16)15-4-7-18-17(12-15)20(28)27(10-11-29-18)13-19-25-8-1-9-26-19/h1-9,12H,10-11,13H2

SMILES Code: O=C1N(CC2=NC=CC=N2)CCOC3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=C13

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 415.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Fuller H, Justo F, Nearing BD, Kahlig KM, Rajamani S, Belardinelli L, Verrier
RL. Eleclazine, a new selective cardiac late sodium current inhibitor, confers
concurrent protection against autonomically induced atrial premature beats,
repolarization alternans and heterogeneity, and atrial fibrillation in an intact
porcine model. Heart Rhythm. 2016 Apr 21. pii: S1547-5271(16)30211-9. doi:
10.1016/j.hrthm.2016.04.015. [Epub ahead of print] PubMed PMID: 27108587.