Amodiaquine free base

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MedKoo CAT#: 317185

CAS#: 86-42-0 (free base)

Description: Amodiaquine (trade names Camoquin, Flavoquine), a 4-aminoquinoline compound related to chloroquine, is used as an antimalarial and anti-inflammatory agent. Amodiaquine has been shown to be more effective than chloroquine in treating chloroquine-resistant Plasmodium falciparum malaria infections and may give more protection than chloroquine when used as weekly prophylaxis. Amodiaquine, like chloroquine, is generally well tolerated. Amodiaquine is a histamine N-methyltransferase inhibitor. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Chemical Structure

Amodiaquine free base
CAS# 86-42-0 (free base)

Theoretical Analysis

MedKoo Cat#: 317185
Name: Amodiaquine free base
CAS#: 86-42-0 (free base)
Chemical Formula: C20H22ClN3O
Exact Mass: 355.14514
Molecular Weight: 355.86
Elemental Analysis: C, 67.50; H, 6.23; Cl, 9.96; N, 11.81; O, 4.50

Price and Availability

Size Price Availability Quantity
50.0mg USD 150.0 Same day
100.0mg USD 250.0 Same day
200.0mg USD 450.0 Same day
500.0mg USD 850.0 Same day
1.0g USD 1450.0 Same day
2.0g USD 2450.0 Same day
5.0g USD 4250.0 Same day
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Related CAS #: 86-42-0 (free base)   69-44-3 (HCl)   6398-98-7 (HCl hydrate)    

Synonym: Camochin; Camoquin; Camoquinal; Camoquine; Flavoquine; Miaquin; NSC 13453; SN-10751; Amodiaquine free base

IUPAC/Chemical Name: 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol


InChi Code: InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)


Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 355.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Niu YR, Wei B, Chen B, Xu LH, Jing X, Peng CL, Ma TZ. Amodiaquine-induced reproductive toxicity in adult male rats. Mol Reprod Dev. 2015 Dec 9. doi: 10.1002/mrd.22603. [Epub ahead of print] PubMed PMID: 26647924.

2: Sow D, Ndiaye JL, Sylla K, Ba MS, Tine RC, Faye B, Pene M, Ndiaye M, Seck A, Lo AC, Abiola A, Dieng Y, Gaye O. Evaluation of the efficacy and safety of three 2-drug combinations for the treatment of uncomplicated Plasmodium falciparum malaria in Senegal: artesunate-amodiaquine, dihydroartemisinin-piperaquine, and artemether-lumefantrine. Med Sante Trop. 2015 Dec 5. [Epub ahead of print] PubMed PMID: 26644184.

3: Yeka A, Kigozi R, Conrad MD, Lugemwa M, Okui P, Katureebe C, Belay K, Kapella BK, Chang MA, Kamya MR, Staedke SG, Dorsey G, Rosenthal PJ. Artesunate/amodiaquine versus artemether/lumefantrine for the treatment of uncomplicated malaria in Uganda: a randomized trial. J Infect Dis. 2015 Nov 23. pii: jiv551. [Epub ahead of print] PubMed PMID: 26597254.

4: Ndounga M, Pembe Issamou Mayengue, Casimiro PN, Koukouikila-Koussounda F, Bitemo M, Diassivy Matondo B, Ndounga Diakou LA, Basco LK, Ntoumi F. Artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in Congolese children under 10 years old living in a suburban area: a randomized study. Malar J. 2015 Oct 29;14(1):423. doi: 10.1186/s12936-015-0918-6. PubMed PMID: 26511848; PubMed Central PMCID: PMC4625922.

5: Ubulom PM, Udobi CE, Madu MI. Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy. J Trop Med. 2015;2015:947390. doi: 10.1155/2015/947390. Epub 2015 Sep 29. PubMed PMID: 26491456; PubMed Central PMCID: PMC4602324.

6: Tsukada C, Saito T, Maekawa M, Mano N, Oda A, Hirasawa N, Hiratsuka M. Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6α-hydroxylation and amodiaquine N-deethylation. Drug Metab Pharmacokinet. 2015 Oct;30(5):366-73. doi: 10.1016/j.dmpk.2015.07.003. Epub 2015 Jul 31. PubMed PMID: 26427316.

7: Yavo W, Konaté A, Kassi FK, Djohan V, Angora EK, Kiki-Barro PC, Vanga-Bosson H, Menan EI. Efficacy and Safety of Artesunate-Amodiaquine versus Artemether-Lumefantrine in the Treatment of Uncomplicated Plasmodium falciparum Malaria in Sentinel Sites across Côte d'Ivoire. Malar Res Treat. 2015;2015:878132. doi: 10.1155/2015/878132. Epub 2015 Aug 12. PubMed PMID: 26347849; PubMed Central PMCID: PMC4549615.

8: Sondo P, Derra K, Diallo-Nakanabo S, Tarnagda Z, Zampa O, Kazienga A, Valea I, Sorgho H, Owusu-Dabo E, Ouedraogo JB, Guiguemde TR, Tinto H. Effectiveness and safety of artemether-lumefantrine versus artesunate-amodiaquine for unsupervised treatment of uncomplicated falciparum malaria in patients of all age groups in Nanoro, Burkina Faso: a randomized open label trial. Malar J. 2015 Aug 20;14:325. doi: 10.1186/s12936-015-0843-8. PubMed PMID: 26289949; PubMed Central PMCID: PMC4545998.

9: Sirikun W, Chatchawalsaisin J, Sutanthavibul N. Solid-State Characterization and Interconversion of Recrystallized Amodiaquine Dihydrochloride in Aliphatic Monohydric Alcohols. AAPS PharmSciTech. 2015 Jul 24. [Epub ahead of print] PubMed PMID: 26206402.

10: Ukah M, Badejoko O, Ogunniyi S, Loto O, Aboderin O, Fatusi A. A randomized trial of artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in pregnancy. Int J Gynaecol Obstet. 2015 Oct;131(1):41-4. doi: 10.1016/j.ijgo.2015.05.009. Epub 2015 Jul 3. PubMed PMID: 26169336.