Amlodipine
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MedKoo CAT#: 317184

CAS#: 88150-42-9 (free base)

Description: Amlodipine (as besylate, mesylate or maleate) is a medication used to lower blood pressure and prevent chest pain. It belongs to a group of medications known as dihydropyridine-type calcium channel blockers. By widening of blood vessels it lowers blood pressure. In angina, amlodipine increases blood flow to the heart muscle to relieve pain due to angina.

Chemical Structure

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Amlodipine
CAS# 88150-42-9 (free base)
Handing Instruction

Theoretical Analysis

MedKoo Cat#: 317184
Name: Amlodipine
CAS#: 88150-42-9 (free base)
Chemical Formula: C20H25ClN2O5
Exact Mass: 408.1452
Molecular Weight: 408.88
Elemental Analysis: C, 58.75; H, 6.16; Cl, 8.67; N, 6.85; O, 19.57

Size Price Shipping out time Quantity
1g USD 250 2 Weeks
2g USD 450 2 Weeks
5g USD 850 2 Weeks
10g USD 1350 2 Weeks
20g USD 2450 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2021-02-27. Prices are subject to change without notice.

Amlodipine, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Related CAS #: 88150-47-4 (maleate)   88150-42-9 (free base)   111470-99-6 (besylate)    

Synonym: Amlodis; Norvasc; Amlocard; Coroval; Amlodipine Besylate; Amlodipine Maleate; Amlodipine Maleate

IUPAC/Chemical Name: (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

InChi Key: HTIQEAQVCYTUBX-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3

SMILES Code: O=C(C1=C(COCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC=C2Cl)OCC

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 408.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gottwald-Hostalek U, Sun N, Barho C, Hildemann S. Management of Hypertension With a Fixed-Dose (Single-Pill) Combination of Bisoprolol and Amlodipine. Clin Pharmacol Drug Dev. 2017 Jan;6(1):9-18. doi: 10.1002/cpdd.309. Epub 2016 Oct 26. PubMed PMID: 27653022.

2: van Zwieten PA. Amlodipine: an overview of its pharmacodynamic and pharmacokinetic properties. Clin Cardiol. 1994 Sep;17(9 Suppl 3):III3-6. Review. PubMed PMID: 9156957.

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Amlodipine

1g / USD 250


Additional Information

Related:
88150-42-9 (Amlodipine)
111470-99-6 (Amlodipine besylate)
88150-47-4(Amlodipine maleate)