WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 317183
Description: Amlexanox, also known as AA-673 and CHX 3673, is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers.
MedKoo Cat#: 317183
Chemical Formula: C16H14N2O4
Exact Mass: 298.09536
Molecular Weight: 298.29
Elemental Analysis: C, 64.42; H, 4.73; N, 9.39; O, 21.45
Synonym: AA-673; AA673; AA 673; CHX 3673; CHX-3673; CHX3673; Amoxanox, Brand name: Aphthasol.
IUPAC/Chemical Name: 2-amino-5-oxo-7-propan-2-ylchromeno[2,3-b]pyridine-3-carboxylic acid
InChi Key: SGRYPYWGNKJSDL-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)
SMILES Code: CC(C)C1=CC2=C(C=C1)OC3=NC(=C(C=C3C2=O)C(=O)O)N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 298.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zhang Y, Guan H, Li J, Fang Z, Chen W, Li F. Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss. Sci Rep. 2015 Sep 4;5:13575. doi: 10.1038/srep13575. PubMed PMID: 26338477; PubMed Central PMCID: PMC4559750.
2: Walash MI, Belal F, Tolba MM, Halawa MI. Micelle-enhanced spectrofluorimetric determination of amlexanox in bioadhesive buccal tablets: application to content uniformity testing. Luminescence. 2015 Sep;30(6):823-9. doi: 10.1002/bio.2828. Epub 2015 Jan 21. PubMed PMID: 25611457.
3: Homan KT, Wu E, Cannavo A, Koch WJ, Tesmer JJ. Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor. Molecules. 2014 Oct 22;19(10):16937-49. doi: 10.3390/molecules191016937. PubMed PMID: 25340299; PubMed Central PMCID: PMC4621012.
4: Ballal V, V J. Oral medicine: amlexanox. Br Dent J. 2014 Sep;217(5):208. doi: 10.1038/sj.bdj.2014.770. PubMed PMID: 25213502.
5: Darshan DD, Kumar CN, Kumar AD, Manikantan NS, Balakrishnan D, Uthkal MP. Clinical study to know the efficacy of Amlexanox 5% with other topical Antiseptic, Analgesic and Anesthetic agents in treating minor RAS. J Int Oral Health. 2014 Feb;6(1):5-11. Epub 2014 Feb 26. PubMed PMID: 24653596; PubMed Central PMCID: PMC3959130.
6: Bhat S, Sujatha D. A clinical evaluation of 5% amlexanox oral paste in the treatment of minor recurrent aphthous ulcers and comparison with the placebo paste: a randomized, vehicle controlled, parallel, single center clinical trial. Indian J Dent Res. 2013 Sep-Oct;24(5):593-8. doi: 10.4103/0970-9290.123382. PubMed PMID: 24355961.
7: Koch L. Obesity: Teaching an old drug new tricks--amlexanox targets inflammation to improve metabolic dysfunction. Nat Rev Endocrinol. 2013 Apr;9(4):185. doi: 10.1038/nrendo.2013.42. Epub 2013 Feb 26. PubMed PMID: 23438840.
8: Gonzalez-Hilarion S, Beghyn T, Jia J, Debreuck N, Berte G, Mamchaoui K, Mouly V, Gruenert DC, Déprez B, Lejeune F. Rescue of nonsense mutations by amlexanox in human cells. Orphanet J Rare Dis. 2012 Aug 31;7:58. doi: 10.1186/1750-1172-7-58. PubMed PMID: 22938201; PubMed Central PMCID: PMC3562214.
9: Fu J, Zhu X, Dan H, Zhou Y, Liu C, Wang F, Li Y, Liu N, Chen Q, Xu Y, Zeng X, Jiang L. Amlexanox is as effective as dexamethasone in topical treatment of erosive oral lichen planus: a short-term pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 May;113(5):638-43. doi: 10.1016/j.oooo.2011.10.013. Epub 2012 Mar 3. PubMed PMID: 22668622.
10: Rani SG, Mohan SK, Yu C. Molecular level interactions of S100A13 with amlexanox: inhibitor for formation of the multiprotein complex in the nonclassical pathway of acidic fibroblast growth factor. Biochemistry. 2010 Mar 23;49(11):2585-92. doi: 10.1021/bi9019077. PubMed PMID: 20178375.