Atropine Sulfate hydrate
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MedKoo CAT#: 317300

CAS#: 5908-99-6 (sulfate)

Description: Atropine sulfate is a competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors. This medication is used before eye examinations and to treat certain eye conditions. It belongs to a class of drugs known as anticholinergics.


Chemical Structure

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Atropine Sulfate hydrate
CAS# 5908-99-6 (sulfate)

Theoretical Analysis

MedKoo Cat#: 317300
Name: Atropine Sulfate hydrate
CAS#: 5908-99-6 (sulfate)
Chemical Formula: C17H27NO8S
Exact Mass:
Molecular Weight: 405.46
Elemental Analysis: C, 50.36; H, 6.71; N, 3.45; O, 31.57; S, 7.91

Size Price Shipping out time Quantity
5g USD 250 2 Weeks
10g USD 450 2 Weeks
25g USD 1650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-02-27. Prices are subject to change without notice.

Atropine Sulfate hydrate, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Related CAS #: 5908-99-6 (sulfate)   6415-90-3 (HBr)   51-55-8 (free base)    

Synonym: Atropine sulphate; Sulfatropinol; Tropintran; Atropette; Corbella; Atropine Sulfate; Atropine Sulfate hydrate/

IUPAC/Chemical Name: (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate;sulfuric acid, hydrate

InChi Key: PVGPXGKNDGTPTD-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H23NO3.H2O4S.H2O/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2

SMILES Code: O=S(O)(O)=O.O=C(OC1CC(N2C)CCC2C1)C(C3=CC=CC=C3)CO.[H]O[H]

Appearance:
White solid powder.

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 405.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Addo RT, Yeboah KG, Siwale RC, Siddig A, Jones A, Ubale RV, Akande J, Nettey
H, Patel NJ, Addo E, D'Souza MJ. Formulation and characterization of atropine
sulfate in albumin-chitosan microparticles for in vivo ocular drug delivery. J
Pharm Sci. 2015 May;104(5):1677-90. doi: 10.1002/jps.24380. Epub 2015 Feb 4.
PubMed PMID: 25652269.

2: Carron M, Veronese S. Atropine sulfate for treatment of bradycardia in a
patient with morbid obesity: what may happen when you least expect it. BMJ Case
Rep. 2015 Jan 29;2015. pii: bcr2014207596. doi: 10.1136/bcr-2014-207596. PubMed
PMID: 25634857.

3: Ensafi AA, Nasr-Esfahani P, Heydari-Bafrooei E, Rezaei B. Determination of
atropine sulfate using a novel sensitive DNA-biosensor based on its interaction
on a modified pencil graphite electrode. Talanta. 2015 Jan;131:149-55. doi:
10.1016/j.talanta.2014.07.082. Epub 2014 Aug 12. PubMed PMID: 25281086.

4: Kovalcuka L, Birgele E, Bandere D, Williams DL. Comparison of the effects of
topical and systemic atropine sulfate on intraocular pressure and pupil diameter
in the normal canine eye. Vet Ophthalmol. 2015 Jan;18(1):43-9. doi:
10.1111/vop.12138. Epub 2014 Jan 16. PubMed PMID: 24428364.

5: Zhang YL, Li YP. [Simultaneous determination of scopolamine hydrobromide,
atropine sulfate, ephedrine hydrochloride and pseudoephedrine hydrochloride in
Zhichuanling oral liquid with HPLC]. Zhongguo Zhong Yao Za Zhi. 2013
Oct;38(19):3291-4. Chinese. PubMed PMID: 24422394.

6: Shen S, Yao J, Shi Y. Quantitative proton nuclear magnetic resonance for the
structural and quantitative analysis of atropine sulfate. J Pharm Biomed Anal.
2014 Feb;89:118-21. doi: 10.1016/j.jpba.2013.10.036. Epub 2013 Nov 7. PubMed
PMID: 24280740.

7: Ettehadi HA, Ghalandari R, Shafaati A, Foroutan SM. Development of a combined
solution formulation of atropine sulfate and obidoxime chloride for autoinjector
and evaluation of its stability. Iran J Pharm Res. 2013 Winter;12(Suppl):31-6.
PubMed PMID: 24250669; PubMed Central PMCID: PMC3813366.

8: Byadagi KS, Nandibewoor ST, Chimatadar SA. Catalytic activity of
ruthenium(III) on the oxidation of an anticholinergic drug-atropine sulfate
monohydrate by copper(III) periodate complex in aqueous alkaline medium -
decarboxylation and free radical mechanism. Acta Chim Slov. 2013;60(3):617-27.
PubMed PMID: 24169716.

9: Abutarbush SM, Alfaqeeh SM, Mustafa G, Qura'n L, Al-Majali AM. Evaluation of
the use of atropine sulfate, a combination of butylscopolammonium bromide and
metamizole sodium, and flunixin meglumine to ameliorate clinical adverse effects
of imidocarb dipropionate in horses. Am J Vet Res. 2013 Nov;74(11):1404-8. doi:
10.2460/ajvr.74.11.1404. PubMed PMID: 24168305.

10: Perkins MW, Pierre Z, Sabnekar P, Sciuto AM, Song J, Soojhawon I, Oguntayo S,
Doctor BP, Nambiar MP. Aerosolized delivery of oxime MMB-4 in combination with
atropine sulfate protects against soman exposure in guinea pigs. Inhal Toxicol.
2012 Aug;24(9):539-49. doi: 10.3109/08958378.2012.691912. PubMed PMID: 22860999.

11: Corcoran TE, Venkataramanan R, Hoffman RM, George MP, Petrov A, Richards T,
Zhang S, Choi J, Gao YY, Oakum CD, Cook RO, Donahoe M. Systemic delivery of
atropine sulfate by the MicroDose Dry-Powder Inhaler. J Aerosol Med Pulm Drug
Deliv. 2013 Feb;26(1):46-55. doi: 10.1089/jamp.2011.0948. Epub 2012 Jun 12.
PubMed PMID: 22691110; PubMed Central PMCID: PMC4227439.

12: Wu H, Fan Z. Mn-doped ZnS quantum dots for the room-temperature
phosphorescence detection of raceanisodamine hydrochloride and atropine sulfate
in biological fluids. Spectrochim Acta A Mol Biomol Spectrosc. 2012 May;90:131-4.
doi: 10.1016/j.saa.2012.01.041. Epub 2012 Jan 27. PubMed PMID: 22336044.

13: Perkins MW, Pierre Z, Rezk P, Song J, Marshall S, Oguntayo S, Morthole V,
Sciuto AM, Doctor BP, Nambiar MP. Endotracheal aerosolization of atropine sulfate
protects against soman-induced acute respiratory toxicity in guinea pigs. Inhal
Toxicol. 2011 Mar;23(4):182-95. doi: 10.3109/08958378.2011.554458. PubMed PMID:
21456952.

14: Survey of Survivors After Out-of-hospital Cardiac Arrest in KANTO Area, Japan
(SOS-KANTO) Study Group. Atropine sulfate for patients with out-of-hospital
cardiac arrest due to asystole and pulseless electrical activity. Circ J.
2011;75(3):580-8. Epub 2011 Jan 8. PubMed PMID: 21233578.

15: Rajpal S, Ali R, Bhatnagar A, Bhandari SK, Mittal G. Clinical and
bioavailability studies of sublingually administered atropine sulfate. Am J Emerg
Med. 2010 Feb;28(2):143-50. doi: 10.1016/j.ajem.2008.10.025. PubMed PMID:
20159382.

16: Uchida M, Yoshida K, Shimizu K. Effect of atropine sulfate on gastric
emptying and gastrocecal transit time evaluated by using the [1-(13)C]acetic acid
and lactose-[(13)C]ureide breath test in conscious rats. J Breath Res. 2009
Dec;3(4):047003. doi: 10.1088/1752-7155/3/4/047003. Epub 2009 Nov 27. PubMed
PMID: 21386200.

17: Siegling-Vlitakis C, Martens H, Lüdtke R. In vitro examination of potentized
atropine sulfate dilutions on the contractility of the isolated rat ileum. J
Altern Complement Med. 2009 Oct;15(10):1121-6. doi: 10.1089/acm.2008.0614. PubMed
PMID: 19824820.

18: Aghamohammadi H, Mehrabi S, Mohammad Ali Beigi F. Prevention of bradycardia
by atropine sulfate during urological laparoscopic surgery: a randomized
controlled trial. Urol J. 2009 Spring;6(2):92-5. PubMed PMID: 19472126.

19: Kameya H, Hokama N, Hobara N, Ohshiro S, Uno T. Effects of a dopamine
receptor agonist and atropine sulfate on absorption of valproic acid in rats.
Biomed Res. 2009 Apr;30(2):101-6. PubMed PMID: 19420733.

20: Shimokawa M, Matsushita S, Kanekura T. Successful treatment of multiple
eccrine hidrocystoma with topical atropine sulfate ointment. J Dermatol. 2009
Feb;36(2):114-5. doi: 10.1111/j.1346-8138.2009.00602.x. PubMed PMID: 19284459.