WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317172

CAS#: 28981-97-7

Description: Alprazolam is not available (DEA controlled substance).

Chemical Structure

CAS# 28981-97-7

Theoretical Analysis

MedKoo Cat#: 317172
Name: Alprazolam
CAS#: 28981-97-7
Chemical Formula: C17H13ClN4
Exact Mass: 308.08287
Molecular Weight: 308.76
Elemental Analysis: C, 66.13; H, 4.24; Cl, 11.48; N, 18.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Xanax; Trankimazin; Tafil; Cassadan; Tranquinal

IUPAC/Chemical Name: 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine


InChi Code: InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3

SMILES Code: CC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 308.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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1: Bruno E, Nicoletti A, Quattrocchi G, Filippini G, Zappia M, Colosimo C. Alprazolam for essential tremor. Cochrane Database Syst Rev. 2015 Dec 6;12:CD009681. [Epub ahead of print] Review. PubMed PMID: 26638213.

2: Spence AL, Guerin GF, Goeders NE. Differential modulation of the discriminative stimulus effects of methamphetamine and cocaine by alprazolam and oxazepam in male and female rats. Neuropharmacology. 2015 Nov 2;102:146-157. doi: 10.1016/j.neuropharm.2015.10.041. [Epub ahead of print] PubMed PMID: 26541330.

3: Holoyda B, Xiong G. Catatonia Associated With Alprazolam Discontinuation in a Young Man With Cardiac Cirrhosis. J Clin Psychopharmacol. 2015 Dec;35(6):735-6. doi: 10.1097/JCP.0000000000000425. PubMed PMID: 26444949.

4: Chen L, Boinpally R, Gad N, Greenberg WM, Wangsa J, Periclou A, Ghahramani P. Evaluation of Cytochrome P450 (CYP) 3A4-Based Interactions of Levomilnacipran with Ketoconazole, Carbamazepine or Alprazolam in Healthy Subjects. Clin Drug Investig. 2015 Oct;35(10):601-12. doi: 10.1007/s40261-015-0318-2. PubMed PMID: 26315684.

5: Kim D, Lee S, Pyeon T, Jeong S. Use of triazolam and alprazolam as premedication for general anesthesia. Korean J Anesthesiol. 2015 Aug;68(4):346-51. doi: 10.4097/kjae.2015.68.4.346. Epub 2015 Jul 28. PubMed PMID: 26257846; PubMed Central PMCID: PMC4524932.

6: Brown GG, Ostrowitzki S, Stein MB, von Kienlin M, Liu TT, Simmons A, Wierenga C, Stein OY, Bruns A, Bischoff-Grethe A, Paulus M. Temporal profile of brain response to alprazolam in patients with generalized anxiety disorder. Psychiatry Res. 2015 Sep 30;233(3):394-401. doi: 10.1016/j.pscychresns.2015.06.016. Epub 2015 Jun 30. PubMed PMID: 26211623.

7: Soria CA, Remedi C, Núñez DA, D'Alessio L, Roldán EJ. Impact of alprazolam in allostatic load and neurocognition of patients with anxiety disorders and chronic stress (GEMA): observational study protocol. BMJ Open. 2015 Jul 14;5(7):e007231. doi: 10.1136/bmjopen-2014-007231. Erratum in: BMJ Open. 2015;5(8):e007231. PubMed PMID: 26173716; PubMed Central PMCID: PMC4513478.

8: Nunes CN, Pauluk LE, Dos Anjos VE, Lopes MC, Quináia SP. New approach to the determination of contaminants of emerging concern in natural water: study of alprazolam employing adsorptive cathodic stripping voltammetry. Anal Bioanal Chem. 2015 Aug;407(20):6171-9. doi: 10.1007/s00216-015-8792-1. Epub 2015 May 30. PubMed PMID: 26025553.

9: Türkoğlu S. Paradoxical reactions related to alprazolam. J Child Adolesc Psychopharmacol. 2015 Apr;25(3):276. doi: 10.1089/cap.2014.0116. PubMed PMID: 25885015.

10: Granoff AL. The impact of benzodiazepine management in the randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy. Am J Psychiatry. 2014 Nov 1;171(11):1222. doi: 10.1176/appi.ajp.2014.14070821. PubMed PMID: 25756634.