L189
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406715

CAS#: 64232-83-3

Description: L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.

Chemical Structure

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L189
CAS# 64232-83-3
Instruction

Theoretical Analysis

MedKoo Cat#: 406715
Name: L189
CAS#: 64232-83-3
Chemical Formula: C11H10N4OS
Exact Mass: 246.06
Molecular Weight: 246.290
Elemental Analysis: C, 53.64; H, 4.09; N, 22.75; O, 6.50; S, 13.02

Price and Availability

Size Price Availability Quantity
10mg USD 90 Ready to ship
50mg USD 150 Ready to ship
100mg USD 250 Ready to ship
200mg USD 450 Ready to ship
500mg USD 750 Ready to ship
1g USD 950 Ready to ship
2g USD 1650 Ready to ship
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Synonym: L189; L 189; L-189.

IUPAC/Chemical Name: (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

InChi Key: SAKOXVNKDMWWLF-AWNIVKPZSA-N

InChi Code: InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)/b13-6+

SMILES Code: O=C(C(/N=C/C1=CC=CC=C1)=C(N)N2)NC2=S

Appearance: Light yellow solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 246.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson GM, MacKerell AD Jr, Tomkinson AE. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-77. doi: 10.1158/0008-5472.CAN-07-6636. PubMed PMID: 18451142; PubMed Central PMCID: PMC2734474.