WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406715
Description: L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
MedKoo Cat#: 406715
Chemical Formula: C11H10N4OS
Exact Mass: 246.05753
Molecular Weight: 246.29
Elemental Analysis: C, 53.64; H, 4.09; N, 22.75; O, 6.50; S, 13.02
L189, purity > 98%, is in stock. The same day shipping out after order is received.
Synonym: L189; L 189; L-189.
IUPAC/Chemical Name: (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
InChi Key: SAKOXVNKDMWWLF-AWNIVKPZSA-N
InChi Code: InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)/b13-6+
SMILES Code: O=C(C(/N=C/C1=CC=CC=C1)=C(N)N2)NC2=S
The following data is based on the product molecular weight 246.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson GM, MacKerell AD Jr, Tomkinson AE. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-77. doi: 10.1158/0008-5472.CAN-07-6636. PubMed PMID: 18451142; PubMed Central PMCID: PMC2734474.