Ischemin sodium

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319533

CAS#: Unknown

Description: Ischemin is a potent CBP bromodomain inhibitor. Schemin alters post-translational modifications on p53 and histones, inhibits p53 interaction with CBP and transcriptional activity in cells, and prevents apoptosis in ischemic cardiomyocytes.

Chemical Structure

Ischemin sodium
CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 319533
Name: Ischemin sodium
CAS#: Unknown
Chemical Formula: C15H16N3NaO4S
Exact Mass:
Molecular Weight: 357.36
Elemental Analysis: C, 50.42; H, 4.51; N, 11.76; Na, 6.43; O, 17.91; S, 8.97

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Synonym: Ischemin sodium salt; J28; J-28; J 28.

IUPAC/Chemical Name: 5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium


InChi Code: InChI=1S/C15H17N3O4S.Na/c1-8-4-10(3)15(23(20,21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16;/h4-7,19H,16H2,1-3H3,(H,20,21,22);/q;+1/p-1/b18-17+;

SMILES Code: O=S(C1=CC(/N=N/C2=CC(C)=C(O)C=C2N)=C(C)C=C1C)([O-])=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 357.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Borah JC, Mujtaba S, Karakikes I, Zeng L, Muller M, Patel J, Moshkina N,
Morohashi K, Zhang W, Gerona-Navarro G, Hajjar RJ, Zhou MM. A small molecule
binding to the coactivator CREB-binding protein blocks apoptosis in
cardiomyocytes. Chem Biol. 2011 Apr 22;18(4):531-41. doi:
10.1016/j.chembiol.2010.12.021. PubMed PMID: 21513889; PubMed Central PMCID: