CJ-463

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407223

CAS#: 600142-19-6

Description: CJ-463 is a potent ans selective uPA inhibitor. Treatment with CJ-463 resulted in a significant inhibition of primary tumor growth, with the highest efficacy seen in the 100 mg/kg group. Urokinase (uPA) plays a crucial role in carcinogenesis by facilitating tumor cell invasion and metastasis. CJ-463 may be a novel agent for treatment of lung cancer.


Chemical Structure

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CJ-463
CAS# 600142-19-6

Theoretical Analysis

MedKoo Cat#: 407223
Name: CJ-463
CAS#: 600142-19-6
Chemical Formula: C21H27N5O6S
Exact Mass: 477.1682
Molecular Weight: 477.536
Elemental Analysis: C, 52.82; H, 5.70; N, 14.67; O, 20.10; S, 6.71

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Synonym: CJ-463; CJ 463; CJ463.

IUPAC/Chemical Name: (S)-N-(4-carbamimidoylbenzyl)-3-hydroxy-2-((R)-3-hydroxy-2-((phenylmethyl)sulfonamido)propanamido)propanamide

InChi Key: ZNOKJHWJKULOGM-ZWKOTPCHSA-N

InChi Code: InChI=1S/C21H27N5O6S/c22-19(23)16-8-6-14(7-9-16)10-24-20(29)17(11-27)25-21(30)18(12-28)26-33(31,32)13-15-4-2-1-3-5-15/h1-9,17-18,26-28H,10-13H2,(H3,22,23)(H,24,29)(H,25,30)/t17-,18+/m0/s1

SMILES Code: N=C(C1=CC=C(CNC([C@@H](NC([C@@H](CO)NS(=O)(CC2=CC=CC=C2)=O)=O)CO)=O)C=C1)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 477.536 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Henneke I, Greschus S, Savai R, Korfei M, Markart P, Mahavadi P, Schermuly RT,
Wygrecka M, Stürzebecher J, Seeger W, Günther A, Ruppert C. Inhibition of
urokinase activity reduces primary tumor growth and metastasis formation in a
murine lung carcinoma model. Am J Respir Crit Care Med. 2010 Mar 15;181(6):611-9.
doi: 10.1164/rccm.200903-0342OC. Epub 2010 Jan 7. PubMed PMID: 20056905.