WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206487
CAS#: 256477-09-5 (free base)
Description: UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). In vitro, UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. UK-371804 was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers.
MedKoo Cat#: 206487
Name: UK-371804
CAS#: 256477-09-5 (free base)
Chemical Formula: C14H16ClN5O4S
Exact Mass: 385.06115
Molecular Weight: 385.823
Elemental Analysis: C, 43.58; H, 4.18; Cl, 9.19; N, 18.15; O, 16.59; S, 8.31
UK-371804 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Related CAS #: 256477-09-5 (free base) 256476-36-5 (HCl)
Synonym: UK-371804; UK371804; UK 371804; UK-371,804; UK 371,804; UK371,804.
IUPAC/Chemical Name: 2-((4-chloro-1-((diaminomethylene)amino)isoquinoline)-7-sulfonamido)-2-methylpropanoic acid
InChi Key: XSDAXWRCPTYNOD-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H16ClN5O4S/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19)
SMILES Code: CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2/N=C(N)\N)=O)C(O)=O
The following data is based on the product molecular weight 385.823 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Fish PV, Barber CG, Brown DG, Butt R, Collis MG, Dickinson RP, Henry BT, Horne VA, Huggins JP, King E, O'Gara M, McCleverty D, McIntosh F, Phillips C, Webster R. Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines. J Med Chem. 2007 May 17;50(10):2341-51. Epub 2007 Apr 21. PubMed PMID: 17447747.
