WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206486

CAS#: 223671-94-1

Description: UK-356,202 is a potent and selective urokinase-type plasminogen activator (Ki = 37 nM). Urokinase plasminogen activator (uPA, urokinase) is a trypsinlike serine protease and a therapeutical target for many cancer types, including breast, ovarian, and pancreatic cancer. uPA is a valuable oncology target.

Chemical Structure

CAS# 223671-94-1

Theoretical Analysis

MedKoo Cat#: 206486
Name: UK-356202
CAS#: 223671-94-1
Chemical Formula: C17H13ClN4O2
Exact Mass: 340.0727
Molecular Weight: 340.767
Elemental Analysis: C, 59.92; H, 3.85; Cl, 10.40; N, 16.44; O, 9.39

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Pricing updated 2021-03-07. Prices are subject to change without notice.

UK-356202 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Synonym: UK-356202; UK356202; UK 356202; UK-356,202; UK356,202; UK 356,202

IUPAC/Chemical Name: 3-(4-chloro-1-guanidinoisoquinolin-7-yl)benzoic acid


InChi Code: InChI=1S/C17H13ClN4O2/c18-14-8-21-15(22-17(19)20)13-7-10(4-5-12(13)14)9-2-1-3-11(6-9)16(23)24/h1-8H,(H,23,24)(H4,19,20,21,22)

SMILES Code: O=C(O)C1=CC=CC(C2=CC3=C(C=C2)C(Cl)=CN=C3NC(N)=N)=C1

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 340.767 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bayliss MA, Venn RF, Edgington AM, Webster R, Walker DK. Determination of a potent urokinase-type plasminogen activator, UK-356,202, in plasma at pg/mL levels using column-switching HPLC and fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):121-6. doi: 10.1016/j.jchromb.2008.11.038. Epub 2008 Dec 3. PubMed PMID: 19119083.

2: Barber CG, Dickinson RP, Fish PV. Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. PubMed PMID: 15149680.