WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206486
CAS#: 223671-94-1
Description: UK-356,202 is a potent and selective urokinase-type plasminogen activator (Ki = 37 nM). Urokinase plasminogen activator (uPA, urokinase) is a trypsinlike serine protease and a therapeutical target for many cancer types, including breast, ovarian, and pancreatic cancer. uPA is a valuable oncology target.
MedKoo Cat#: 206486
Name: UK-356202
CAS#: 223671-94-1
Chemical Formula: C17H13ClN4O2
Exact Mass: 340.0727
Molecular Weight: 340.767
Elemental Analysis: C, 59.92; H, 3.85; Cl, 10.40; N, 16.44; O, 9.39
UK-356202 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Synonym: UK-356202; UK356202; UK 356202; UK-356,202; UK356,202; UK 356,202
IUPAC/Chemical Name: 3-(4-chloro-1-guanidinoisoquinolin-7-yl)benzoic acid
InChi Key: UXNWIRHZMHGOCE-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H13ClN4O2/c18-14-8-21-15(22-17(19)20)13-7-10(4-5-12(13)14)9-2-1-3-11(6-9)16(23)24/h1-8H,(H,23,24)(H4,19,20,21,22)
SMILES Code: O=C(O)C1=CC=CC(C2=CC3=C(C=C2)C(Cl)=CN=C3NC(N)=N)=C1
The following data is based on the product molecular weight 340.767 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Bayliss MA, Venn RF, Edgington AM, Webster R, Walker DK. Determination of a potent urokinase-type plasminogen activator, UK-356,202, in plasma at pg/mL levels using column-switching HPLC and fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):121-6. doi: 10.1016/j.jchromb.2008.11.038. Epub 2008 Dec 3. PubMed PMID: 19119083.
2: Barber CG, Dickinson RP, Fish PV. Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. PubMed PMID: 15149680.