UK-356202

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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206486

CAS#: 223671-94-1

Description: UK-356,202 is a potent and selective urokinase-type plasminogen activator (Ki = 37 nM). Urokinase plasminogen activator (uPA, urokinase) is a trypsinlike serine protease and a therapeutical target for many cancer types, including breast, ovarian, and pancreatic cancer. uPA is a valuable oncology target.

Price and Availability

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Pricing updated 2020-10-31. Prices are subject to change without notice.

UK-356202 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 206486
Name: UK-356202
CAS#: 223671-94-1
Chemical Formula: C17H13ClN4O2
Exact Mass: 340.0727
Molecular Weight: 340.767
Elemental Analysis: C, 59.92; H, 3.85; Cl, 10.40; N, 16.44; O, 9.39

Synonym: UK-356202; UK356202; UK 356202; UK-356,202; UK356,202; UK 356,202

IUPAC/Chemical Name: 3-(4-chloro-1-guanidinoisoquinolin-7-yl)benzoic acid

InChi Key: UXNWIRHZMHGOCE-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H13ClN4O2/c18-14-8-21-15(22-17(19)20)13-7-10(4-5-12(13)14)9-2-1-3-11(6-9)16(23)24/h1-8H,(H,23,24)(H4,19,20,21,22)

SMILES Code: O=C(O)C1=CC=CC(C2=CC3=C(C=C2)C(Cl)=CN=C3NC(N)=N)=C1

Technical Data

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO, not in water

Shelf Life:

>2 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

References

1: Bayliss MA, Venn RF, Edgington AM, Webster R, Walker DK. Determination of a potent urokinase-type plasminogen activator, UK-356,202, in plasma at pg/mL levels using column-switching HPLC and fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3):121-6. doi: 10.1016/j.jchromb.2008.11.038. Epub 2008 Dec 3. PubMed PMID: 19119083.

2: Barber CG, Dickinson RP, Fish PV. Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-isoquinolinylguanidines. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3227-30. PubMed PMID: 15149680.

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