WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319530

CAS#: 10537-47-0

Description: Malonoben, also known as AG-17 or Tyrphostin-9, is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 460 µM in the human epidermoid carcinoma cell line A431.

Chemical Structure

CAS# 10537-47-0

Theoretical Analysis

MedKoo Cat#: 319530
Name: Malonoben
CAS#: 10537-47-0
Chemical Formula: C18H22N2O
Exact Mass: 282.17321
Molecular Weight: 282.387
Elemental Analysis: C, 76.56; H, 7.85; N, 9.92; O, 5.67

Price and Availability

Size Price Availability Quantity
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 2250.0 2 Weeks
1.0g USD 3250.0 2 Weeks
2.0g USD 4850.0 2 Weeks
5.0g USD 6450.0 2 Weeks
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Synonym: Tyrphostin-9; Tyrphostin 9; Tyrphostin 9; Malonoben; Tyrphostin AG-17; SF 6847; GCP 5126; RG-50872; NSC 242557.

IUPAC/Chemical Name: 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-propanedinitrile


InChi Code: InChI=1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3

SMILES Code: N#C/C(C#N)=C/C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 282.387 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Singh J, Lee BK. Recovery of precious metals from low-grade automobile shredder residue: A novel approach for the recovery of nanozero-valent copper particles. Waste Manag. 2015 Oct 30. pii: S0956-053X(15)30168-9. doi: 10.1016/j.wasman.2015.10.019. [Epub ahead of print] PubMed PMID: 26525968.

2: Kibitov AO, Voskoboeva EY, Chuprova NA. [The 444G/A and -1021 C/T polymorphisms of the dopamine-beta-hydroxylase gene modulate the trajectory of alcohol dependence development]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(5):68-75. Russian. PubMed PMID: 26356164.

3: Kazennova EV, Neshumaev DA, Rukavitsin DV, Lapovok IA, Laga VIu, Rakcheeva OV, Vasil'ev AV, Tumanov AS, Vorontsova GA, Kuznetsova AV, Loĭfman EA, Starukhina IN, Kustova OI, Polovitsa NV, Lipskaia NA, Bobkova MR. [Molecular epidemiological analysis of the HIV infection in the Blagoveshchensk and Khabarovsk Area (Russian Far East)]. Vopr Virusol. 2014 Jul-Aug;59(4):31-6. Russian. PubMed PMID: 25549465.

4: Masci E, Pellicano R, Mangiavillano B, Luigiano C, Stelitano L, Morace C, Viale E, Freschi M, Locatelli M, Ieri R, Cavallaro A, Testoni S, Testoni PA. GastroPanel® test for non-invasive diagnosis of atrophic gastritis in patients with dyspepsia. Minerva Gastroenterol Dietol. 2014 Mar;60(1):79-83. PubMed PMID: 24632770.

5: Imai H, Tanaka Y, Nomura N, Tsutsumi Y, Doi H, Kanno Z, Ohno K, Ono T, Hanawa T. Three-dimensional quantification of susceptibility artifacts from various metals in magnetic resonance images. Acta Biomater. 2013 Sep;9(9):8433-9. doi: 10.1016/j.actbio.2013.05.017. Epub 2013 May 24. PubMed PMID: 23707948.

6: Gottschalk F, Kost E, Nowack B. Engineered nanomaterials in water and soils: a risk quantification based on probabilistic exposure and effect modeling. Environ Toxicol Chem. 2013 Jun;32(6):1278-87. doi: 10.1002/etc.2177. Epub 2013 Apr 16. PubMed PMID: 23418073.

7: Tang PH, Wu TM, Hsu PJ, Lai SK. Melting behavior of Ag14 cluster: an order parameter by instantaneous normal modes. J Chem Phys. 2012 Dec 28;137(24):244304. doi: 10.1063/1.4772096. PubMed PMID: 23277933.

8: Martín A, Martínez-Espada N, Mena M, Pérez-Redondo A, Yélamos C. Copper(I) and silver(I) complexes supported by the tridentate [{Ti(η(5)-C5Me5)(μ-NH)}3(μ3-N)] metalloligand. Inorg Chem. 2013 Jan 18;52(2):918-30. doi: 10.1021/ic302113k. Epub 2012 Dec 26. PubMed PMID: 23268605.

9: Iqbal S, Zhang S, Driss A, Liu ZR, Kim HR, Wang Y, Ritenour C, Zhau HE, Kucuk O, Chung LW, Wu D. PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells. PLoS One. 2012;7(1):e30764. doi: 10.1371/journal.pone.0030764. Epub 2012 Jan 20. PubMed PMID: 22276222; PubMed Central PMCID: PMC3262835.

10: Sun D, Liu FJ, Huang RB, Zheng LS. Anionic heptadecanuclear silver(I) cluster constructed from in situ generated 2-mercaptobenzoic acid and a sulfide anion. Inorg Chem. 2011 Dec 19;50(24):12393-5. doi: 10.1021/ic201746q. Epub 2011 Nov 9. PubMed PMID: 22070282.

11: Tang PH, Wu TM, Yen TW, Lai SK, Hsu PJ. Comparative study of cluster Ag17Cu2 by instantaneous normal mode analysis and by isothermal Brownian-type molecular dynamics simulation. J Chem Phys. 2011 Sep 7;135(9):094302. doi: 10.1063/1.3628669. PubMed PMID: 21913758.

12: Kargl F, Engelhardt M, Yang F, Weis H, Schmakat P, Schillinger B, Griesche A, Meyer A. In situ studies of mass transport in liquid alloys by means of neutron radiography. J Phys Condens Matter. 2011 Jun 29;23(25):254201. doi: 10.1088/0953-8984/23/25/254201. Epub 2011 Jun 9. PubMed PMID: 21654050.

13: Shopova SI, Rajmangal R, Nishida Y, Arnold S. Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser. Rev Sci Instrum. 2010 Oct;81(10):103110. doi: 10.1063/1.3499261. PubMed PMID: 21034078.

14: Zuniga J, Housh TJ, Camic CL, Mielke M, Hendrix CR, Johnson GO, Housh DJ, Schmidt RJ. Yearly changes in the anthropometric dimensions of female high school gymnasts. J Strength Cond Res. 2011 Jan;25(1):124-8. doi: 10.1519/JSC.0b013e3181bb0d92. PubMed PMID: 20179650.

15: Yada K, Abe T, Haga N. Studies of Paramecium caudatum by means of scanning electron microscope and projection X-ray microscope. Biomed Mater Eng. 2009;19(2-3):87-92. doi: 10.3233/BME-2009-0567. PubMed PMID: 19581701.

16: Chang W, Chen J, Schlueter CF, Hoyle GW. Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells. Exp Lung Res. 2009 May;35(4):324-43. doi: 10.1080/01902140802712738. PubMed PMID: 19415549; PubMed Central PMCID: PMC2694966.

17: Kruit A, Tilanus-Linthorst MM, Boonstra JG, van Schaik RH, Grutters JC, van den Bosch JM, Ruven HJ. MUC1 568 A/G genotype-dependent cancer antigen 15-3 levels in breast cancer patients. Clin Biochem. 2009 May;42(7-8):662-5. doi: 10.1016/j.clinbiochem.2008.11.020. Epub 2008 Dec 24. PubMed PMID: 19121298.

18: Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008 Aug 22;283(34):23139-49. doi: 10.1074/jbc.M710308200. Epub 2008 Jun 17. PubMed PMID: 18559345.

19: Dammanahalli JK, Sun Z. Endothelin (ET)-1 inhibits nicotinamide adenine dinucleotide phosphate oxidase activity in human abdominal aortic endothelial cells: a novel function of ETB1 receptors. Endocrinology. 2008 Oct;149(10):4979-87. doi: 10.1210/en.2008-0199. Epub 2008 Jun 5. PubMed PMID: 18535108; PubMed Central PMCID: PMC2582923.

20: Stillman MJ. Spectroscopic studies of copper and silver binding to metallothioneins. Met Based Drugs. 1999;6(4-5):277-90. doi: 10.1155/MBD.1999.277. PubMed PMID: 18475903; PubMed Central PMCID: PMC2365167.


100.0mg / USD 750.0