Bopindolol Malonate

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MedKoo CAT#: 317330

CAS#: 82857-38-3 (malonate)

Description: Bopindolol malonate is a non-selective, potent, long-acting beta adrenoceptor antagonist. It demonstrates inhibition of H2O2-induced lipid peroxdiation. Bopindolol malonate slowly dissociates into the active metabolites 4-(3-tert-butylamino-2-hydroxypropoxy)-2-methyl indole and 4-(3-tert-butylaminopropoxy)-2-carboxyl indole which both demonstrate potent β1-adrenoceptor blocking activity.

Chemical Structure

Bopindolol Malonate
CAS# 82857-38-3 (malonate)

Theoretical Analysis

MedKoo Cat#: 317330
Name: Bopindolol Malonate
CAS#: 82857-38-3 (malonate)
Chemical Formula: C26H32N2O7
Exact Mass:
Molecular Weight: 484.54
Elemental Analysis: C, 64.45; H, 6.66; N, 5.78; O, 23.11

Price and Availability

Size Price Availability Quantity
100.0mg USD 180.0 2 Weeks
500.0mg USD 500.0 2 Weeks
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Related CAS #: 62658-63-3 (free base)   79125-22-7 (furamate)   82857-38-3 (malonate)    

Synonym: Bopindolol Malonate; Bopindolol malonate; AC1LCS45; SCHEMBL348872; CTK8F8315; HE393689; LS-120081; D01794; Sandonorm; Bopindolol hydrogen malonate; Wandonorm; Sandonorm (TN)

IUPAC/Chemical Name: [1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl] benzoate;propanedioic acid


InChi Code: InChI=1S/C23H28N2O3.C3H4O4/c1-16-13-19-20(25-16)11-8-12-21(19)27-15-18(14-24-23(2,3)4)28-22(26)17-9-6-5-7-10-17;4-2(5)1-3(6)7/h5-13,18,24-25H,14-15H2,1-4H3;1H2,(H,4,5)(H,6,7)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight 484.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Belal F, Sharaf El-Din M, Aly F, Hefnawy M, El-Awady M. Fluorometric
determination of bopindolol and celiprolol in pharmaceutical preparations and
biological fluids. J Fluoresc. 2012 Jul;22(4):1141-50. doi:
10.1007/s10895-012-1053-1. Epub 2012 Apr 3. PubMed PMID: 22477063.

2: Meireles J, Sklenárová H, Satínský D, Solich P, Araújo AN, Montenegro MC.
Determination of bopindolol using the flow injection technique coupled with solid
phase extraction. J Pharm Biomed Anal. 2003 Dec 4;33(5):1149-53. PubMed PMID:

3: Satínský D, Sklenárová H, Huclová J, Karlícek R. Determination of bopindolol
by sequential injection technique with spectrophotometric detection. Farmaco.
2003 Oct;58(10):1057-62. PubMed PMID: 14505739.

4: Kruk I, Michalska T, Kladna A, Aboul-Enein HY. Spin trapping study of reactive
oxygen species formation during bopindolol peroxidation. Biopolymers. 2002 Oct
15;65(2):89-94. PubMed PMID: 12209459.

5: Urbánek M, Pospísilová M, Polásek M. Determination of bopindolol in
pharmaceuticals by capillary isotachophoresis. J Pharm Biomed Anal. 2002 May
15;28(3-4):509-15. PubMed PMID: 12008130.

6: Nagatomo T, Hosohata Y, Ohnuki T, Nakamura T, Hattori K, Suzuki J, Ishiguro M.
Bopindolol: pharmacological basis and clinical implications. Cardiovasc Drug Rev.
2001 Spring;19(1):9-24. Review. PubMed PMID: 11314603.

7: Nakamura T, Suzuki A, Ohnuki T, Hattori K, Watanabe K, Kurose H, Nagao T,
Nagatomo T. Assessment of affinities of propranolol and bopindolol to membranes
from COS-7 cell transiently transfected with beta-1- and beta-2-adrenoceptors
using a radioligand-binding assay method. Pharmacology. 2000 Jul;61(1):6-10.
PubMed PMID: 10895074.

8: Hattori K, Suzuki J, Hosohata Y, Ohnuki T, Nakamura T, Watanabe K, Muramatsu
I, Nagatomo T. Sustaining effects of bopindolol on inhibitory chronotropic
actions in guinea pig atria. Pharmacology. 1999 Oct;59(4):183-91. PubMed PMID:

9: Hattori K, Ishiguro M, Ohnuki T, Nakamura T, Muramatsu I, Nagatomo T.
Identification of binding sites of bopindolol and its two metabolites with
beta1-adrenoceptors by molecular modeling: comparison with beta2 adrenoceptors.
Pharmacology. 1999 Apr;58(4):183-9. PubMed PMID: 10077737.

10: Hosohata Y, Hattori K, Shen Y, Okuyama M, Kaneko H, Ohnuki T, Suzuki J,
Nagatomo T. Bopindolol: a slowly dissociating antagonist from the
beta-adrenoceptors in guinea pig atria. Pharmacology. 1998 Oct;57(4):180-7.
PubMed PMID: 9730775.

11: Aboul-Enein HY, Kruk I, Lichszteld K. Chemiluminescence accompanying
oxidation of bopindolol. Biospectroscopy. 1998;4(4):229-33. PubMed PMID: 9706382.

12: Bagatin J, Sardelić S, Pivac N, Polić S, Ljutic D, Rakic D, Naranca M, Bojić
L, Kovacić Z, Rumboldt Z. Comparison of chlorthalidone, propranolol and
bopindolol in six-month treatment of arterial hypertension. Int J Clin Pharmacol
Res. 1998;18(2):73-8. PubMed PMID: 9675624.

13: Nagatomo T, Ishiguro M, Ohnuki T, Hattori K, Hosohata Y, Takatsu N, Katayama
H, Watanabe K. Studies on relationships between chemical structure and
beta-blocking potency of bopindolol and its two metabolites. Life Sci.
1998;62(17-18):1597-600. PubMed PMID: 9585142.

14: Nagatomo T, Hosohata Y, Ohnuki T, Suzuki J. [Pharmacological characteristics
of the long-acting beta-blocker "bopindolol"]. Nihon Yakurigaku Zasshi. 1997
Jan;109(1):1-12. Review. Japanese. PubMed PMID: 9067994.

15: Hosohata Y, Sasaki K, Maruyama K, Ohnuki T, Hattori K, Suzuki J, Watanabe K,
Nagatomo T. Effects of chronic administration of bopindolol on the binding
characteristics of cardiac alpha 1H-, alpha 1L-, beta 1- and beta 2-adrenoceptor
subtypes in cardiac muscles of spontaneously hypertensive rats (SHR). Biol Pharm
Bull. 1996 Jul;19(7):932-5. PubMed PMID: 8839963.

16: Widimský J, Lánská V, Hulínský V, Balazovjech I, Havlík V, Havránek P, Kroupa
E, Nikodýmová L, Pátek F, Svítil F, Svihovcová P. [Treatment of hypertension with
a fixed combination of bopindolol and chlorthalidone (Sandoretic)]. Vnitr Lek.
1996 Apr;42(4):223-8. Czech. PubMed PMID: 8693706.

17: Hosohata Y, Sasaki K, Shen Y, Hattori K, Suzuki J, Nagatomo T. Bopindolol is
a slowly dissociating beta 1-adrenoceptor antagonist when compared to other
beta-blockers. Biol Pharm Bull. 1995 Aug;18(8):1066-71. PubMed PMID: 8535397.

18: Hosohata Y, Sasaki K, Suzuki M, Karakisawa Y, Maruyama K, Tsuchihashi H,
Nagatomo T. Alpha-1 and beta-adrenergic receptor blocking potencies of bopindolol
and its two metabolites (18-502 and 20-785) as assessed by radioligand binding
assay methods. Gen Pharmacol. 1995 Jul;26(4):743-7. PubMed PMID: 7635249.

19: Aniya Y, Fong KF, Naito A, Sakanashi M. Antioxidative action of the
beta-adrenoceptor antagonist bopindolol and its metabolite 18-502. Jpn J
Pharmacol. 1995 Jul;68(3):323-9. PubMed PMID: 7474556.

20: Hosohata Y, Suzuki M, Karakisawa Y, Maruyama K, Nagatomo T. The affinity of
bopindolol and its two metabolites for a beta 2-adrenoceptor in the bovine
mesenteric artery. Biol Pharm Bull. 1994 Sep;17(9):1296-8. PubMed PMID: 7841957.