Bisoprolol Hemifumarate
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MedKoo CAT#: 317329

CAS#: 104344-23-2

Description: Bisoprolol hemifumarate is a cardioselective beta-1 adrenergic blocker. It is effective in the management of hypertension and angina pectoris. Bisoprolol hemifumarate has antihypertensive and potential cardioprotective activities. Devoid of intrinsic sympathomimetic activity, bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, decreasing cardiac contractility and rate, reducing cardiac output, and lowering blood pressure.


Chemical Structure

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Bisoprolol Hemifumarate
CAS# 104344-23-2

Theoretical Analysis

MedKoo Cat#: 317329
Name: Bisoprolol Hemifumarate
CAS#: 104344-23-2
Chemical Formula: C22H35NO8
Exact Mass:
Molecular Weight: 441.52
Elemental Analysis: C, 59.85; H, 7.99; N, 3.17; O, 28.99

Size Price Shipping out time Quantity
10mg USD 190 2 weeks
25mg USD 220 2 weeks
50mg USD 340 2 weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-09. Prices are subject to change without notice.

Bisoprolol Hemifumarate purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: Bisoprolol hemifumarate; Bisoprolol hemifumarate salt; Zebeta; (+/-)-Bisoprolol hemifumarate; Bisobloc; Fumarate, Bisoprolol

IUPAC/Chemical Name: (E)-but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol

InChi Key: VMDFASMUILANOL-WXXKFALUSA-N

InChi Code: InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+

SMILES Code: CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 441.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Wroczyński P. Cloud-point extraction is compatible with liquid chromatography
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7: Tagliamonte E, Cirillo T, Rigo F, Astarita C, Coppola A, Romano C, Capuano N.
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13: Hefner G, Unterecker S, Shams ME, Wolf M, Falter T, Haen E, Hiemke C.
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of ion-pair complexation with chemical enhancers for the synchronous permeation
of indapamide and bisoprolol in their compound patch through rabbit skin. Eur J
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19: Elzanfaly ES, Hassan SA, Salem MY, El-Zeany BA. Different signal processing
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of bisoprolol and hydrochlorothiazide; a comparative study. Spectrochim Acta A
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