Bisoprolol hemifumarate
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MedKoo CAT#: 317329

CAS#: 104344-23-2

Description: Bisoprolol hemifumarate is a cardioselective beta-1 adrenergic blocker. It is effective in the management of hypertension and angina pectoris. Bisoprolol hemifumarate has antihypertensive and potential cardioprotective activities. Devoid of intrinsic sympathomimetic activity, bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, decreasing cardiac contractility and rate, reducing cardiac output, and lowering blood pressure. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).


Chemical Structure

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Bisoprolol hemifumarate
CAS# 104344-23-2

Theoretical Analysis

MedKoo Cat#: 317329
Name: Bisoprolol hemifumarate
CAS#: 104344-23-2
Chemical Formula: C22H35NO8
Exact Mass: 0.00
Molecular Weight: 441.520
Elemental Analysis: Chemical Formula: C40H66N2O12 Molecular Weight: 766.97 Elemental Analysis: C, 62.64; H, 8.67; N, 3.65; O, 25.03

Price and Availability

Size Price Availability Quantity
100mg USD 350 2 weeks
250mg USD 650 2 weeks
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Synonym: Bisoprolol hemifumarate; Bisoprolol hemifumarate salt; Zebeta; (+/-)-Bisoprolol hemifumarate; Bisobloc; Fumarate, Bisoprolol;

IUPAC/Chemical Name: 1-(4-((2-isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol hemifumarate

InChi Key: VMDFASMUILANOL-WXXKFALUSA-N

InChi Code: InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+

SMILES Code: OC(=O)\C=C\C(O)=O.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1.CC(C)NCC(O)COC1=CC=C(COCCOC(C)C)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 441.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Giebułtowicz J, Kojro G, Buś-Kwaśnik K, Rudzki PJ, Marszałek R, Leś A,
Wroczyński P. Cloud-point extraction is compatible with liquid chromatography
coupled to electrospray ionization mass spectrometry for the determination of
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2: Kesek M, Rydberg A, Jensen SM. Two Cases of LQT-Syndrome with Malignant
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3: Perreault S, de Denus S, White M, White-Guay B, Bouvier M, Dorais M, Dubé M,
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Carvedilol Versus β1-Selective β Blockers (Bisoprolol, Metoprolol, and Nebivolol)
in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary
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5: Tariovskaya EI, Skibitskiy VV, Malchikova SV, Fendrikova AV, Skibitskiy AV,
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6: Williams B, MacDonald TM, Morant S, Webb DJ, Sever P, McInnes G, Ford I,
Cruickshank JK, Caulfield MJ, Salsbury J, Mackenzie I, Padmanabhan S, Brown MJ;
British Hypertension Society's PATHWAY Studies Group. Spironolactone versus
placebo, bisoprolol, and doxazosin to determine the optimal treatment for
drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover
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7: Tagliamonte E, Cirillo T, Rigo F, Astarita C, Coppola A, Romano C, Capuano N.
Ivabradine and Bisoprolol on Doppler-derived Coronary Flow Velocity Reserve in
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8: Hostalek U, Czarnecka D, Koch EM. Treatment of Hypertensive Patients with a
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9: Zhang M, Wu A, Shen Y, Chen H, Tu J, Zhai C. [Effects of L-carnitine and
bisoprolol on endoplasmic reticulum stress-mediated myocardial injury after
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10: Hara T, Yagi S, Akaike M, Sata M. Transdermal patch of bisoprolol for the
treatment of hypertension complicated with aortic dissection. Int J Cardiol. 2015
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PMID: 26173061.


11: Marothu VK, Yerramothu P, Gorrepati M, Majeti S, Mamidala SK, Nellutla A.
Application of HPLC to assess the compatibility of bisoprolol fumarate with
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PMID: 26142745.


12: Karlova NA, Zolozova EA, Pshenitsin AI, Chigineva VV, Karlov AA, Saiutina EV,
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13: Hefner G, Unterecker S, Shams ME, Wolf M, Falter T, Haen E, Hiemke C.
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CYP2D6: evidence from a therapeutic drug monitoring survey. J Neural Transm
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17: Chesnikova AI, Safronenko VA, Kolomatskaia OE. [Evaluating the effectiveness
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18: Song W, Cun D, Quan P, Liu N, Chen Y, Cui H, Xiang R, Fang L.
Dual-directional regulation of drug permeating amount by combining the technique
of ion-pair complexation with chemical enhancers for the synchronous permeation
of indapamide and bisoprolol in their compound patch through rabbit skin. Eur J
Pharm Biopharm. 2015 Apr;91:59-65. doi: 10.1016/j.ejpb.2015.01.025. Epub 2015 Feb
4. PubMed PMID: 25660911.


19: Elzanfaly ES, Hassan SA, Salem MY, El-Zeany BA. Different signal processing
techniques of ratio spectra for spectrophotometric resolution of binary mixture
of bisoprolol and hydrochlorothiazide; a comparative study. Spectrochim Acta A
Mol Biomol Spectrosc. 2015 Apr 5;140:334-43. doi: 10.1016/j.saa.2014.12.107. Epub
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20: Eguchi K, Hoshide S, Kario K. Effects of Celiprolol and Bisoprolol on Blood
Pressure, Vascular Stiffness, and Baroreflex Sensitivity. Am J Hypertens. 2015
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25577782.