VWN 44232

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317329

CAS#: 104344-23-2

Description: VWN 44232, also known as Bisoprolol hemifumarate is a cardioselective beta-1 adrenergic blocker. It is effective in the management of hypertension and angina pectoris. Bisoprolol hemifumarate has antihypertensive and potential cardioprotective activities. Devoid of intrinsic sympathomimetic activity, bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, decreasing cardiac contractility and rate, reducing cardiac output, and lowering blood pressure. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

VWN 44232
CAS# 104344-23-2

Theoretical Analysis

MedKoo Cat#: 317329
Name: VWN 44232
CAS#: 104344-23-2
Chemical Formula: C22H35NO8
Exact Mass:
Molecular Weight: 441.52
Elemental Analysis: C, 59.85; H, 7.99; N, 3.17; O, 28.99

Price and Availability

Size Price Availability Quantity
10.0mg USD 190.0 2 weeks
25.0mg USD 220.0 2 weeks
50.0mg USD 340.0 2 weeks
Bulk inquiry

Synonym: Bisoprolol hemifumarate; Bisoprolol hemifumarate salt; Zebeta; (+/-)-Bisoprolol hemifumarate; Bisobloc; Fumarate, Bisoprolol; VWN-44232; VWN 44232; VWN44232

IUPAC/Chemical Name: (E)-but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol


InChi Code: InChI=1S/2C18H31NO4.C4H4O4/c2*1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h2*5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 441.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Giebułtowicz J, Kojro G, Buś-Kwaśnik K, Rudzki PJ, Marszałek R, Leś A,
Wroczyński P. Cloud-point extraction is compatible with liquid chromatography
coupled to electrospray ionization mass spectrometry for the determination of
bisoprolol in human plasma. J Chromatogr A. 2015 Dec 4;1423:39-46. doi:
10.1016/j.chroma.2015.10.076. Epub 2015 Oct 29. PubMed PMID: 26572051.

2: Kesek M, Rydberg A, Jensen SM. Two Cases of LQT-Syndrome with Malignant
Syncope after Switch from Propranolol to Bisoprolol. Pacing Clin Electrophysiol.
2015 Nov 9. doi: 10.1111/pace.12783. [Epub ahead of print] PubMed PMID: 26548443.

3: Perreault S, de Denus S, White M, White-Guay B, Bouvier M, Dorais M, Dubé M,
Rouleau J, Tardif J, Jenna S, Haibe-Kains B, Leduc R, Deblois D. Association of
Treatment with Carvedilol, Bisoprolol and Metoprolol on the Risk of Mortality and
Hospital Admission Among Older Adults with Heart Failure. Value Health. 2015
Nov;18(7):A379. doi: 10.1016/j.jval.2015.09.801. Epub 2015 Oct 20. PubMed PMID:

4: Seo GW, Kim DK, Kim KH, Seol SH, Jin HY, Yang TH, Ahn Y, Jeong MH, Song PS,
Kim DI; Other Korea Acute Myocardial Infarction Registry Investigators. Impact of
Carvedilol Versus β1-Selective β Blockers (Bisoprolol, Metoprolol, and Nebivolol)
in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary
Intervention. Am J Cardiol. 2015 Nov 15;116(10):1502-8. doi:
10.1016/j.amjcard.2015.08.013. Epub 2015 Aug 31. PubMed PMID: 26520013.

5: Tariovskaya EI, Skibitskiy VV, Malchikova SV, Fendrikova AV, Skibitskiy AV,
Sirotenko DV. [Pharmacoeconomic Efficacy of a Fixed Combination of Bisoprolol and
Amlodipine]. Kardiologiia. 2015;55(4):25-9. Russian. PubMed PMID: 26502499.

6: Williams B, MacDonald TM, Morant S, Webb DJ, Sever P, McInnes G, Ford I,
Cruickshank JK, Caulfield MJ, Salsbury J, Mackenzie I, Padmanabhan S, Brown MJ;
British Hypertension Society's PATHWAY Studies Group. Spironolactone versus
placebo, bisoprolol, and doxazosin to determine the optimal treatment for
drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover
trial. Lancet. 2015 Sep 18. pii: S0140-6736(15)00257-3. doi:
10.1016/S0140-6736(15)00257-3. [Epub ahead of print] PubMed PMID: 26414968.

7: Tagliamonte E, Cirillo T, Rigo F, Astarita C, Coppola A, Romano C, Capuano N.
Ivabradine and Bisoprolol on Doppler-derived Coronary Flow Velocity Reserve in
Patients with Stable Coronary Artery Disease: Beyond the Heart Rate. Adv Ther.
2015 Aug;32(8):757-67. doi: 10.1007/s12325-015-0237-x. Epub 2015 Aug 21. PubMed
PMID: 26293212; PubMed Central PMCID: PMC4569671.

8: Hostalek U, Czarnecka D, Koch EM. Treatment of Hypertensive Patients with a
Fixed-Dose Combination of Bisoprolol and Amlodipine: Results of a Cohort study
with More Than 10,000 Patients. Cardiol Ther. 2015 Aug 8. [Epub ahead of print]
PubMed PMID: 26253777.

9: Zhang M, Wu A, Shen Y, Chen H, Tu J, Zhai C. [Effects of L-carnitine and
bisoprolol on endoplasmic reticulum stress-mediated myocardial injury after
cardiopulmonary resuscitation in rats]. Zhonghua Yi Xue Za Zhi. 2015 May
19;95(19):1475-8. Chinese. PubMed PMID: 26178496.

10: Hara T, Yagi S, Akaike M, Sata M. Transdermal patch of bisoprolol for the
treatment of hypertension complicated with aortic dissection. Int J Cardiol. 2015
Nov 1;198:220-1. doi: 10.1016/j.ijcard.2015.06.112. Epub 2015 Jun 30. PubMed
PMID: 26173061.

11: Marothu VK, Yerramothu P, Gorrepati M, Majeti S, Mamidala SK, Nellutla A.
Application of HPLC to assess the compatibility of bisoprolol fumarate with
selected excipients in mixtures by isothermal stress testing. Ann Pharm Fr. 2015
Nov;73(6):442-51. doi: 10.1016/j.pharma.2015.05.001. Epub 2015 Jul 2. PubMed
PMID: 26142745.

12: Karlova NA, Zolozova EA, Pshenitsin AI, Chigineva VV, Karlov AA, Saiutina EV,
Solomasova LV, Mazur NA. [Assessment of the therapeutic efficacy and safety of
the original bisoprolol and its generic biprol in patients with stable angina].
Kardiologiia. 2015;55(1):23-8. Russian. PubMed PMID: 26050485.

13: Hefner G, Unterecker S, Shams ME, Wolf M, Falter T, Haen E, Hiemke C.
Melperone but not bisoprolol or metoprolol is a clinically relevant inhibitor of
CYP2D6: evidence from a therapeutic drug monitoring survey. J Neural Transm
(Vienna). 2015 Nov;122(11):1609-17. doi: 10.1007/s00702-015-1403-7. Epub 2015 May
5. PubMed PMID: 25940834.

14: Pasternak B, Mattsson A, Svanström H, Hviid A. Comparative effectiveness of
bisoprolol and metoprolol succinate in patients with heart failure. Int J
Cardiol. 2015 Jul 1;190:4-6. doi: 10.1016/j.ijcard.2015.03.441. Epub 2015 Apr 18.
PubMed PMID: 25912106.

15: Aparicio LS, Alfie J, Barochiner J, Cuffaro PE, Giunta DH, Elizondo CM,
Tortella JJ, Morales MS, Rada MA, Waisman GD. Comparison of atenolol versus
bisoprolol with noninvasive hemodynamic and pulse wave assessment. J Am Soc
Hypertens. 2015 May;9(5):390-6. doi: 10.1016/j.jash.2015.02.013. Epub 2015 Feb
23. PubMed PMID: 25816713.

16: Czarnecka D, Koch EM, Gottwald-Hostalek U. Benefits of a fixed-dose
combination of bisoprolol and amlodipine in the treatment of hypertension in
daily practice: results of more than 4000 patients. Curr Med Res Opin. 2015
May;31(5):875-81. doi: 10.1185/03007995.2015.1027676. Epub 2015 Apr 8. PubMed
PMID: 25753136.

17: Chesnikova AI, Safronenko VA, Kolomatskaia OE. [Evaluating the effectiveness
of a fixed combination of amlodipine and bisoprolol in ambulatory patients with
arterial hypertension and ischemic heart disease]. Kardiologiia.
2014;54(9):17-23. Russian. PubMed PMID: 25702398.

18: Song W, Cun D, Quan P, Liu N, Chen Y, Cui H, Xiang R, Fang L.
Dual-directional regulation of drug permeating amount by combining the technique
of ion-pair complexation with chemical enhancers for the synchronous permeation
of indapamide and bisoprolol in their compound patch through rabbit skin. Eur J
Pharm Biopharm. 2015 Apr;91:59-65. doi: 10.1016/j.ejpb.2015.01.025. Epub 2015 Feb
4. PubMed PMID: 25660911.

19: Elzanfaly ES, Hassan SA, Salem MY, El-Zeany BA. Different signal processing
techniques of ratio spectra for spectrophotometric resolution of binary mixture
of bisoprolol and hydrochlorothiazide; a comparative study. Spectrochim Acta A
Mol Biomol Spectrosc. 2015 Apr 5;140:334-43. doi: 10.1016/j.saa.2014.12.107. Epub
2015 Jan 3. PubMed PMID: 25615684.

20: Eguchi K, Hoshide S, Kario K. Effects of Celiprolol and Bisoprolol on Blood
Pressure, Vascular Stiffness, and Baroreflex Sensitivity. Am J Hypertens. 2015
Jul;28(7):858-67. doi: 10.1093/ajh/hpu245. Epub 2015 Jan 10. PubMed PMID: