Andarine
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MedKoo CAT#: 319520

CAS#: 401900-40-1

Description: Andarine, also known as GTx-007 and S-4, is an investigational selective androgen receptor modulator (SARM) for treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy. Andarine is an orally active partial agonist for androgen receptors. It is less potent in both anabolic and androgenic effects than other SARMs. In an animal model of benign prostatic hypertrophy, andarine was shown to reduce prostate weight with similar efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.


Price and Availability

Size Price Shipping out time Quantity
1g USD 150 Same Day
2g USD 250 Same Day
5g USD 450 Same Day
10g USD 750 Same Day
20g USD 1250 Same Day
50g USD 1950 Same Day
100g USD 2950 Same Day
200g USD 3950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-22. Prices are subject to change without notice.

Andarine, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319520
Name: Andarine
CAS#: 401900-40-1
Chemical Formula: C19H18F3N3O6
Exact Mass: 441.11477
Molecular Weight: 441.36321
Elemental Analysis: C, 51.71; H, 4.11; F, 12.91; N, 9.52; O, 21.75


Synonym: GTx-007; GTx007; GTx 007; S-4; S4; S 4; Andarine

IUPAC/Chemical Name: (2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide

InChi Key: YVXVTLGIDOACBJ-SFHVURJKSA-N

InChi Code: InChI=1S/C19H18F3N3O6/c1-11(26)23-12-3-6-14(7-4-12)31-10-18(2,28)17(27)24-13-5-8-16(25(29)30)15(9-13)19(20,21)22/h3-9,28H,10H2,1-2H3,(H,23,26)(H,24,27)/t18-/m0/s1

SMILES Code: O=C(NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1)[C@@](C)(O)COC2=CC=C(NC(C)=O)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Cawley AT, Smart C, Greer C, Liu Lau M, Keledjian J. Detection of the selective androgen receptor modulator andarine (S-4) in a routine equine blood doping control sample. Drug Test Anal. 2015 Oct 12. doi: 10.1002/dta.1867. [Epub ahead of print] PubMed PMID: 26456227.

2: Girgis CM, Mokbel N, Digirolamo DJ. Therapies for musculoskeletal disease: can we treat two birds with one stone? Curr Osteoporos Rep. 2014 Jun;12(2):142-53. doi: 10.1007/s11914-014-0204-5. Review. PubMed PMID: 24633910; PubMed Central PMCID: PMC4083371.

3: de Rijke E, Essers ML, Rijk JC, Thevis M, Bovee TF, van Ginkel LA, Sterk SS. Selective androgen receptor modulators: in vitro and in vivo metabolism and analysis. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(9):1517-26. doi: 10.1080/19440049.2013.810346. Epub 2013 Jul 24. PubMed PMID: 23883284.

4: Starcevic B, Ahrens BD, Butch AW. Detection of the selective androgen receptor modulator S-4 (Andarine) in a doping control sample. Drug Test Anal. 2013 May;5(5):377-9. doi: 10.1002/dta.1466. Epub 2013 Feb 21. PubMed PMID: 23427117.

5: Thomas A, Geyer H, Schänzer W, Crone C, Kellmann M, Moehring T, Thevis M. Sensitive determination of prohibited drugs in dried blood spots (DBS) for doping controls by means of a benchtop quadrupole/Orbitrap mass spectrometer. Anal Bioanal Chem. 2012 May;403(5):1279-89. doi: 10.1007/s00216-011-5655-2. Epub 2012 Jan 10. PubMed PMID: 22231507.

6: Guddat S, Solymos E, Orlovius A, Thomas A, Sigmund G, Geyer H, Thevis M, Schänzer W. High-throughput screening for various classes of doping agents using a new 'dilute-and-shoot' liquid chromatography-tandem mass spectrometry multi-target approach. Drug Test Anal. 2011 Nov-Dec;3(11-12):836-50. doi: 10.1002/dta.372. Epub 2011 Dec 2. PubMed PMID: 22135086.

7: Grata E, Perrenoud L, Saugy M, Baume N. SARM-S4 and metabolites detection in sports drug testing: a case report. Forensic Sci Int. 2011 Dec 10;213(1-3):104-8. doi: 10.1016/j.forsciint.2011.07.014. Epub 2011 Aug 3. PubMed PMID: 21816554.

8: Thevis M, Thomas A, Möller I, Geyer H, Dalton JT, Schänzer W. Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls. Rapid Commun Mass Spectrom. 2011 Aug 15;25(15):2187-95. doi: 10.1002/rcm.5100. PubMed PMID: 21710598.

9: Kohler M, Thomas A, Geyer H, Petrou M, Schänzer W, Thevis M. Confiscated black market products and nutritional supplements with non-approved ingredients analyzed in the Cologne Doping Control Laboratory 2009. Drug Test Anal. 2010 Nov-Dec;2(11-12):533-7. doi: 10.1002/dta.186. Epub 2010 Oct 26. Review. PubMed PMID: 21204286.

10: Thevis M, Thomas A, Fusshöller G, Beuck S, Geyer H, Schänzer W. Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator andarine (S-4) for routine doping control purposes. Rapid Commun Mass Spectrom. 2010 Aug 15;24(15):2245-54. doi: 10.1002/rcm.4637. PubMed PMID: 20623476.

11: Jones A, Hwang DJ, Narayanan R, Miller DD, Dalton JT. Effects of a novel selective androgen receptor modulator on dexamethasone-induced and hypogonadism-induced muscle atrophy. Endocrinology. 2010 Aug;151(8):3706-19. doi: 10.1210/en.2010-0150. Epub 2010 Jun 9. PubMed PMID: 20534726.

12: Thevis M, Geyer H, Kamber M, Schänzer W. Detection of the arylpropionamide-derived selective androgen receptor modulator (SARM) S-4 (Andarine) in a black-market product. Drug Test Anal. 2009 Aug;1(8):387-92. doi: 10.1002/dta.91. PubMed PMID: 20355219.

13: Furuya K. [Bone and Men's Health. Bone selective androgen receptor modulators]. Clin Calcium. 2010 Feb;20(2):225-33. doi: CliCa1002225233. Review. Japanese. PubMed PMID: 20118515.

14: Kearbey JD, Gao W, Narayanan R, Fisher SJ, Wu D, Miller DD, Dalton JT. Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. Pharm Res. 2007 Feb;24(2):328-35. Epub 2006 Oct 25. PubMed PMID: 17063395; PubMed Central PMCID: PMC2039878.

15: Perera MA, Yin D, Wu D, Chan KK, Miller DD, Dalton J. In vivo metabolism and final disposition of a novel nonsteroidal androgen in rats and dogs. Drug Metab Dispos. 2006 Oct;34(10):1713-21. Epub 2006 Jun 30. PubMed PMID: 16815963.

16: Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbey JD, Miller DD, Dalton JT. Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology. 2005 Nov;146(11):4887-97. Epub 2005 Aug 11. PubMed PMID: 16099859; PubMed Central PMCID: PMC2039881.

17: Kearbey JD, Wu D, Gao W, Miller DD, Dalton JT. Pharmacokinetics of S-3-(4-acetylamino-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro- 3-trifluoromethyl-phenyl)-propionamide in rats, a non-steroidal selective androgen receptor modulator. Xenobiotica. 2004 Mar;34(3):273-80. PubMed PMID: 15204699; PubMed Central PMCID: PMC2040234.