Neomycin B sulfate
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MedKoo CAT#: 319519

CAS#: 4146-30-9 (sulfate)

Description: Neomycin is an aminoglycoside antibiotic found in many topical medications such as creams, ointments, and eyedrops. Neomycin belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds. Similar to other aminoglycosides, neomycin has excellent activity against Gram-negative bacteria, and has partial activity against Gram-positive bacteria. It is relatively toxic to humans, and many people have allergic reactions to it. Aminoglycosides such as neomycin are known for their ability to bind to duplex RNA with high affinity.


Chemical Structure

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Neomycin B sulfate
CAS# 4146-30-9 (sulfate)

Theoretical Analysis

MedKoo Cat#: 319519
Name: Neomycin B sulfate
CAS#: 4146-30-9 (sulfate)
Chemical Formula: C23H52N6O25S3
Exact Mass:
Molecular Weight: 908.866
Elemental Analysis: C, 30.40; H, 5.77; N, 9.25; O, 44.01; S, 10.58

Price and Availability

Size Price Availability Quantity
2.0g USD 250.0 2 Weeks
10.0g USD 450.0 2 Weeks
25.0g USD 750.0 2 Weeks
100.0g USD 1650.0 2 Weeks
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Related CAS #: 119-04-0 (free base)   4146-30-9 (sulfate)   28002-70-2 (sulfate)    

Synonym: Framycetin sulphate; Neomycin B sulfate; Neomycin B trisulfate;

IUPAC/Chemical Name: (2R,3R,4S,5S,6S)-5-amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxytetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulfate

InChi Key: KWBUARAINLGYMG-JGMIRXPNSA-N

InChi Code: InChI=1S/C23H46N6O13.3H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;;;/m1.../s1

SMILES Code: NC[C@@H]1O[C@@H]([C@@H]([C@H]([C@@H]1O)O)N)O[C@H]2[C@H]([C@@H](O[C@@H]2CO)O[C@@H]3[C@H]([C@@H](C[C@@H]([C@H]3O[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4N)O)O)CN)N)N)O)O.OS(=O)(O)=O.OS(=O)(O)=O.OS(=O)(O)=O

Appearance: Solid powder

Purity: >85% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 908.866 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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