Bimolane
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MedKoo CAT#: 319517

CAS#: 74550-97-3

Description: Bimolane is a topoisomerase II inhibitor. Bimolane has been widely used in China as an anti-neoplastic agent and for the treatment of psoriasis. Bimolane is also a leukemogenic agent and is thought to exert its effects through the inhibition of topoisomerase II. The results of enzyme and DNA titration assays indicate that inhibition of topoisomerase II by bimolane occurred through interactions with DNA, similar to the mechanism seen with the epipodophyllotoxin-type inhibitors. These results provide evidence that bimolane is an inhibitor of topoisomerase II in vitro.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 450 2 weeks
100mg USD 750 2 weeks
200mg USD 1250 2 weeks
500mg USD 1950 2 weeks
1g USD 2950 2 weeks
2g USD 4850 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-24. Prices are subject to change without notice.

Bimolane, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319517
Name: Bimolane
CAS#: 74550-97-3
Chemical Formula: C20H32N6O6
Exact Mass: 452.23833
Molecular Weight: 452.512
Elemental Analysis: C, 53.09; H, 7.13; N, 18.57; O, 21.21


Synonym: AT-1727; AT1727; AT 1727; CCRIS 7574; CCRIS7574; CCRIS-7574; NSC 351358; Bimolane.

IUPAC/Chemical Name: 1-(morpholin-4-ylmethyl)-4-[2-[4-(morpholin-4-ylmethyl)-3,5-dioxopiperazin-1-yl]ethyl]piperazine-2,6-dione

InChi Key: JGQGCJKPBAYEHO-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H32N6O6/c27-17-11-23(12-18(28)25(17)15-21-3-7-31-8-4-21)1-2-24-13-19(29)26(20(30)14-24)16-22-5-9-32-10-6-22/h1-16H2

SMILES Code: O=C(CN(CCN1CC(N(CN2CCOCC2)C(C1)=O)=O)C3)N(CN4CCOCC4)C3=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Vuong MC, Hasegawa LS, Eastmond DA. A comparative study of the cytotoxic and genotoxic effects of ICRF-154 and bimolane, two catalytic inhibitors of topoisomerase II. Mutat Res. 2013 Jan 20;750(1-2):63-71. doi: 10.1016/j.mrgentox.2012.09.005. Epub 2012 Sep 21. PubMed PMID: 23000430.

2: Roy SK, Eastmond DA. Bimolane induces multiple types of chromosomal aberrations in human lymphocytes in vitro. Mutat Res. 2011 Dec 24;726(2):181-7. doi: 10.1016/j.mrgentox.2011.09.006. Epub 2011 Sep 16. PubMed PMID: 21944901.

3: Frantz CE, Smith H, Eades DM, Grosovsky AJ, Eastmond DA. Bimolane: in vitro inhibitor of human topoisomerase II. Cancer Lett. 1997 Dec 9;120(2):135-40. PubMed PMID: 9461029.

4: Xue Y, Guo Y, Xie X. Translocation t(7;11)(P15;P15) in a patient with therapy-related acute myeloid leukemia following bimolane and ICRF-154 treatment for psoriasis. Leuk Res. 1997 Feb;21(2):107-9. PubMed PMID: 9112426.

5: Chen SQ, Xue KX, Wu JZ, Ma GJ. [Mutagenic effects of bimolane]. Zhongguo Yao Li Xue Bao. 1995 Nov;16(6):531-3. Chinese. PubMed PMID: 8732050.

6: Xue KX, Ma GJ, Wu JZ. [Effects of bimolane on cell cycle cytokinesis in human lymphocytes in vitro]. Zhongguo Yao Li Xue Bao. 1994 Jan;15(1):87-9. Chinese. PubMed PMID: 8010096.

7: Zhang MH, Wang XY, Gao LS. [140 cases of acute leukemia caused by bimolane]. Zhonghua Nei Ke Za Zhi. 1993 Oct;32(10):668-72. Chinese. PubMed PMID: 8156836.

8: Xue Y, Lu D, Guo Y, Lin B. Specific chromosomal translocations and therapy-related leukemia induced by bimolane therapy for psoriasis. Leuk Res. 1992 Nov;16(11):1113-23. PubMed PMID: 1434747.

9: Xu B, Noah PW, Skinner RB Jr, Bale G, Chesney TM, Rosenberg EW. Efficacy of bimolane in the Malassezia ovalis model of psoriasis. J Dermatol. 1991 Dec;18(12):707-13. PubMed PMID: 1806601.

10: Chen LJ, Wang MY, Liu MZ. [Reproductive toxicity of bimolane in mice and rabbits]. Zhongguo Yao Li Xue Bao. 1989 Nov;10(6):557-60. Chinese. PubMed PMID: 2641857.

11: Dan N, Zhang TM. [Effects of bimolane on immune responses in mice]. Zhongguo Yao Li Xue Bao. 1988 Sep;9(5):471-4. Chinese. PubMed PMID: 3064552.

12: Wang MY, Liu TX, Li GD, Zhang TM. [Effects of bimolane and probimane on the incorporation of (3H)TdR, (3H)UR and (3H)Leu into Ehrlich ascites carcinoma cells iv vitro]. Zhongguo Yao Li Xue Bao. 1988 Jul;9(4):367-9. Chinese. PubMed PMID: 3195348.

13: Zhang YP, Chen YN, Fan GC, Xia SX. [Relationship between radiation sensitization and DNA damage by bimolane]. Zhongguo Yao Li Xue Bao. 1987 Mar;8(2):177-80. Chinese. PubMed PMID: 2959009.

14: Ren YF, Otter GM, Schmid FA. Further evaluation of bimolane and analogs as potential antitumor agents. Eur J Cancer Clin Oncol. 1985 Apr;21(4):493-7. PubMed PMID: 3859415.

15: Camerman N, Hempel A, Camerman A. Bimolane: structure determination indicates anticancer activity is attributable to ICRF-154. Science. 1984 Sep 14;225(4667):1165-6. PubMed PMID: 6474171.

16: Huang KW, Fu NW, Ren YF. [Effects of bimolane on size, metastases and cyclic AMP levels of Lewis lung carcinoma]. Zhongguo Yao Li Xue Bao. 1984 Mar;5(1):69-71. Chinese. PubMed PMID: 6326466.

17: Lin C, Zhang TM. [The cytokinetic effects of bimolane (AT-1727) on S180 cells]. Yao Xue Xue Bao. 1982 Sep;17(9):654-7. Chinese. PubMed PMID: 7158349.

18: Zhang TM, Chen ZY, Lin C. [Pharmacological studies on bimolane (AT-1727), a new antineoplastic agent (author's transl)]. Yao Xue Xue Bao. 1980 Oct;15(10):577-83. Chinese. PubMed PMID: 7257778.