WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 319515
Description: Acumapimod, also known as BCT-197, is a potent P38 mitogen-activated protein kinase inhibitor. The p38 protein kinases, in particular p38α and p38β, regulate the production of multiple inflammatory mediators.
MedKoo Cat#: 319515
Name: Acumapimod (BCT-197)
Chemical Formula: C22H19N5O2
Exact Mass: 385.15387
Molecular Weight: 385.427
Elemental Analysis: C, 68.56; H, 4.97; N, 18.17; O, 8.30
Synonym: BCT-197; BCT197; BCT 197; BCT197A2201; Acumapimod
IUPAC/Chemical Name: 3-(5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide
InChi Key: VGUSQKZDZHAAEE-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H19N5O2/c1-13-5-6-16(22(29)26-17-7-8-17)10-19(13)27-21(24)18(12-25-27)20(28)15-4-2-3-14(9-15)11-23/h2-6,9-10,12,17H,7-8,24H2,1H3,(H,26,29)
SMILES Code: O=C(NC1CC1)C2=CC=C(C)C(N3N=CC(C(C4=CC=CC(C#N)=C4)=O)=C3N)=C2
Appearance: Yellow to orange solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 385.427 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Norman P. Investigational p38 inhibitors for the treatment of chronic
obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92.
doi: 10.1517/13543784.2015.1006358. Epub 2015 Jan 20. Review. PubMed PMID: