Acumapimod (BCT-197)
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 319515

CAS#: 836683-15-9

Description: Acumapimod, also known as BCT-197, is a potent P38 mitogen-activated protein kinase inhibitor. The p38 protein kinases, in particular p38α and p38β, regulate the production of multiple inflammatory mediators.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 3250
Size
Price

25mg
USD 250
200mg
USD 1250
2g
Ask price
Size
Price

50mg
USD 450
500mg
USD 1950
5g
Ask price

Acumapimod (BCT-197), purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 5g may be 2 months.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 319515
Name: Acumapimod (BCT-197)
CAS#: 836683-15-9
Chemical Formula: C22H19N5O2
Exact Mass: 385.15387
Molecular Weight: 385.427
Elemental Analysis: C, 68.56; H, 4.97; N, 18.17; O, 8.30


Synonym: BCT-197; BCT197; BCT 197; BCT197A2201; Acumapimod

IUPAC/Chemical Name: 3-(5-amino-4-(3-cyanobenzoyl)-1H-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide

InChi Key: VGUSQKZDZHAAEE-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H19N5O2/c1-13-5-6-16(22(29)26-17-7-8-17)10-19(13)27-21(24)18(12-25-27)20(28)15-4-2-3-14(9-15)11-23/h2-6,9-10,12,17H,7-8,24H2,1H3,(H,26,29)

SMILES Code: O=C(NC1CC1)C2=CC=C(C)C(N3N=CC(C(C4=CC=CC(C#N)=C4)=O)=C3N)=C2


Technical Data

Appearance:
Yellow to orange solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Norman P. Investigational p38 inhibitors for the treatment of chronic
obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92.
doi: 10.1517/13543784.2015.1006358. Epub 2015 Jan 20. Review. PubMed PMID:
25599809.