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MedKoo CAT#: 522506
CAS#: 175135-47-4
Description: O4I1 is a potent inducer of Oct3/4. O4I1 enhanced Oct3/4 expression. O4I1 not only promoted expression and stabilization of Oct3/4 but also enhanced its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine. Reprogramming somatic cells into induced-pluripotent cells (iPSCs) provides new access to all somatic cell types for clinical application without any ethical controversy arising from the use of embryonic stem cells (ESCs).
MedKoo Cat#: 522506
Name: O4I1
CAS#: 175135-47-4
Chemical Formula: C16H15NO2
Exact Mass: 253.11028
Molecular Weight: 253.301
Elemental Analysis: C, 75.87; H, 5.97; N, 5.53; O, 12.63
Synonym: O4I1; O4I-1; O4I 1
IUPAC/Chemical Name: 4-[(4-Methoxyphenyl)methoxy]benzeneacetonitrile
InChi Key: QJEJLARVLKHYFW-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H15NO2/c1-18-15-6-4-14(5-7-15)12-19-16-8-2-13(3-9-16)10-11-17/h2-9H,10,12H2,1H3
SMILES Code: N#CCC1=CC=C(OCC2=CC=C(OC)C=C2)C=C1
1: Cheng X, Dimou E, Alborzinia H, Wenke F, Göhring A, Reuter S, Mah N, Fuchs H,
Andrade-Navarro MA, Adjaye J, Gul S, Harms C, Utikal J, Klipp E, Mrowka R, Wölfl
S. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and
Derivatives as Potent Oct3/4 Inducers. J Med Chem. 2015 Jun 25;58(12):4976-83.
doi: 10.1021/acs.jmedchem.5b00144. Epub 2015 May 7. PubMed PMID: 25898186.