WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522506
CAS#: 175135-47-4
Description: O4I1 is a potent inducer of Oct3/4. O4I1 enhanced Oct3/4 expression. O4I1 not only promoted expression and stabilization of Oct3/4 but also enhanced its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine. Reprogramming somatic cells into induced-pluripotent cells (iPSCs) provides new access to all somatic cell types for clinical application without any ethical controversy arising from the use of embryonic stem cells (ESCs).
MedKoo Cat#: 522506
Name: O4I1
CAS#: 175135-47-4
Chemical Formula: C16H15NO2
Exact Mass: 253.11028
Molecular Weight: 253.301
Elemental Analysis: C, 75.87; H, 5.97; N, 5.53; O, 12.63
Synonym: O4I1; O4I-1; O4I 1
IUPAC/Chemical Name: 4-[(4-Methoxyphenyl)methoxy]benzeneacetonitrile
InChi Key: QJEJLARVLKHYFW-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H15NO2/c1-18-15-6-4-14(5-7-15)12-19-16-8-2-13(3-9-16)10-11-17/h2-9H,10,12H2,1H3
SMILES Code: N#CCC1=CC=C(OCC2=CC=C(OC)C=C2)C=C1
Appearance: Light yellow solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 253.301 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Cheng X, Dimou E, Alborzinia H, Wenke F, Göhring A, Reuter S, Mah N, Fuchs H,
Andrade-Navarro MA, Adjaye J, Gul S, Harms C, Utikal J, Klipp E, Mrowka R, Wölfl
S. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and
Derivatives as Potent Oct3/4 Inducers. J Med Chem. 2015 Jun 25;58(12):4976-83.
doi: 10.1021/acs.jmedchem.5b00144. Epub 2015 May 7. PubMed PMID: 25898186.
