WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522505
CAS#: 165682-93-9
Description: O4I2 is a potent inducers of Oct3/4. O4I2 showed high activity in enforcing Oct3/4 expression. O4I2 is a new class of small molecules suitable for iPSC generation. The octamer-binding transcription factor 4 (Oct3/4) is a master gene in the transcriptional regulatory network of pluripotent cells. Repression of Oct3/4 in embryonic stem cells (ESCs) is associated with cell differentiation and loss of pluripotency, whereas forced overexpression in cooperation with other transcriptional factors, such as Nanog, Sox2, and Lin28, can reprogram somatic cells back into pluripotent cells, termed induced pluripotent stem cells (iPSCs).
MedKoo Cat#: 522505
Name: O4I2
CAS#: 165682-93-9
Chemical Formula: C12H11ClN2O2S
Exact Mass: 282.02298
Molecular Weight: 282.742
Elemental Analysis: C, 50.98; H, 3.92; Cl, 12.54; N, 9.91; O, 11.32; S, 11.34
Synonym: O4I2; O-4I2; O4I-2.
IUPAC/Chemical Name: ethyl 2-((4-chlorophenyl)amino)thiazole-4-carboxylate
InChi Key: ULUBAPWNHROTEU-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H11ClN2O2S/c1-2-17-11(16)10-7-18-12(15-10)14-9-5-3-8(13)4-6-9/h3-7H,2H2,1H3,(H,14,15)
SMILES Code: O=C(C1=CSC(NC2=CC=C(Cl)C=C2)=N1)OCC
1: Cheng X, Yoshida H, Raoofi D, Saleh S, Alborzinia H, Wenke F, Göhring A,
Reuter S, Mah N, Fuchs H, Andrade-Navarro MA, Adjaye J, Gul S, Utikal J, Mrowka
R, Wölfl S. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives
Are Potent Inducers of Oct3/4. J Med Chem. 2015 Aug 13;58(15):5742-50. doi:
10.1021/acs.jmedchem.5b00226. Epub 2015 Jul 23. PubMed PMID: 26143659.
