LY2409881
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407218

CAS#: 946518-60-1

Description: LY2409881 is a potent and selective IKK2 inhibitor. LY2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of NF-κB. LY2409881 inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. LY2409881 suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs.


Chemical Structure

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LY2409881
CAS# 946518-60-1

Theoretical Analysis

MedKoo Cat#: 407218
Name: LY2409881
CAS#: 946518-60-1
Chemical Formula: C24H29ClN6OS
Exact Mass: 484.18121
Molecular Weight: 485.047
Elemental Analysis: C, 59.43; H, 6.03; Cl, 7.31; N, 17.33; O, 3.30; S, 6.61

Size Price Shipping out time Quantity
5mg USD 90 2 Weeks
10mg USD 150 2 Weeks
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2650 2 Weeks
2g USD 3650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-08. Prices are subject to change without notice.

LY2409881, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: LY2409881; LY-2409881; LY 2409881.

IUPAC/Chemical Name: 2-(5-chloro-2-((3-(4-methylpiperazin-1-yl)propyl)amino)pyrimidin-4-yl)-N-cyclopropylbenzo[b]thiophene-4-carboxamide

InChi Key: BNFAYJPQCPZQND-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H29ClN6OS/c1-30-10-12-31(13-11-30)9-3-8-26-24-27-15-19(25)22(29-24)21-14-18-17(4-2-5-20(18)33-21)23(32)28-16-6-7-16/h2,4-5,14-16H,3,6-13H2,1H3,(H,28,32)(H,26,27,29)

SMILES Code: O=C(C1=C(C=C(C2=NC(NCCCN3CCN(CC3)C)=NC=C2Cl)S4)C4=CC=C1)NC5CC5

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 485.047 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Deng C, Lipstein M, Rodriguez R, Serrano XO, McIntosh C, Tsai WY, Wasmuth AS,
Jaken S, O'Connor OA. The novel IKK2 inhibitor LY2409881 potently synergizes with
histone deacetylase inhibitors in preclinical models of lymphoma through the
downregulation of NF-κB. Clin Cancer Res. 2015 Jan 1;21(1):134-45. doi:
10.1158/1078-0432.CCR-14-0384. Epub 2014 Oct 29. PubMed PMID: 25355930.