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MedKoo CAT#: 407199
CAS#: 196868-63-0
Description: PQ401 is a potent and selective IGF-1R inhibitor. PQ-401 induces apoptosis and inhibits growth, proliferation and migration of glioma cells. PQ401 not only induced cellular apoptosis in U87MG cells and subsequently reduced cell viability and proliferation but also attenuated cell mobility in vitro. More importantly, through a mouse xenograft model, administration of PQ401 on mice led to suppression of glioma tumour growth in vivo. PQ401 may serve as a promising leading drug for treating glioma patients with elevated IGF-1R signalling.
MedKoo Cat#: 407199
Name: PQ401
CAS#: 196868-63-0
Chemical Formula: C18H16ClN3O2
Exact Mass: 341.0931
Molecular Weight: 341.795
Elemental Analysis: C, 63.25; H, 4.72; Cl, 10.37; N, 12.29; O, 9.36
Synonym: PQ401; PQ-401; PQ 401.
IUPAC/Chemical Name: N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
InChi Key: YBLWOZUPHDKFOT-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
SMILES Code: O=C(NC1=CC(C)=NC2=CC=CC=C12)NC3=CC(Cl)=CC=C3OC
1: Zhou X, Zhao X, Li X, Ping G, Pei S, Chen M, Wang Z, Zhou W, Jin B. PQ401, an IGF-1R inhibitor, induces apoptosis and inhibits growth, proliferation and migration of glioma cells. J Chemother. 2015 May 14:1973947815Y0000000026. [Epub ahead of print] PubMed PMID: 25971682.
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