WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 318866
CAS#: 3313-26-6 (Z-isomer)
Description: Tiotixene or Thiothixene is a typical antipsychotic drug of the thioxanthene class used in the treatment of psychoses like schizophrenia. It was introduced on July 24, 1967 by Pfizer. NSC 108165
MedKoo Cat#: 318866
Name: Thiothixene
CAS#: 3313-26-6 (Z-isomer)
Chemical Formula: C23H29N3O2S2
Exact Mass: 443.17012
Molecular Weight: 443.624
Elemental Analysis: C, 62.27; H, 6.59; N, 9.47; O, 7.21; S, 14.45
Thiothixene is in stock.
Related CAS #: 3313-26-6 (Z-isomer) 5591-45-7 (E-isomer) 3285-50-5 (maleate) 3285-54-9 (oxalate) 22189-31-7 (HCl)
Synonym: CP 12,252-1; NSC 108165; P 4657B; Navane; Navan; Navaron; Orbinamo; Tiotixeno; Thixit; Thiothixene; Tiotixene; (Z)-Thiothixene; cis-Thiothixene;
IUPAC/Chemical Name: (Z)-N,N-dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9H-thioxanthene-2-sulfonamide
InChi Key: GFBKORZTTCHDGY-UWVJOHFNSA-N
InChi Code: InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8-
SMILES Code: O=S(C1=CC(/C2=C\CCN3CCN(C)CC3)=C(SC4=C2C=CC=C4)C=C1)(N(C)C)=O
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Soluble in DMSO, not in water | 100.0 |
The following data is based on the product molecular weight 443.624 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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8: Buchsbaum MS, Potkin SG, Marshall JF, Lottenberg S, Teng C, Heh CW, Tafalla R, Reynolds C, Abel L, Plon L, et al. Effects of clozapine and thiothixene on glucose metabolic rate in schizophrenia. Neuropsychopharmacology. 1992 May;6(3):155-63. PubMed PMID: 1599606.
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13: Davis CM, Harrington CA. Quantitation of thiothixene in plasma by high-performance thin-layer chromatography and fluorometric detection. Ther Drug Monit. 1988;10(2):215-23. PubMed PMID: 3381241.
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18: Sarai K, Okada M. Comparison of efficacy of zotepine and thiothixene in schizophrenia in a double-blind study. Pharmacopsychiatry. 1987 Feb;20(1 Spec No):38-46. PubMed PMID: 2883680.
19: Goldberg SC, Schulz SC, Resnick RJ, Hamer RM, Schulz PM. Differential prediction of response to thiothixene and placebo in borderline and schizotypal personality disorders. Psychopharmacol Bull. 1987;23(3):342-6. PubMed PMID: 3324147.
20: Hollister LE, Lombrozo L, Huang CC. Plasma concentrations of thiothixene and clinical response in treatment-resistant schizophrenics. Int Clin Psychopharmacol. 1987 Jan;2(1):77-82. PubMed PMID: 3312399.
