Thiabendazole
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 318857

CAS#: 148-79-8

Description: Thiabendazole is a fungicide and parasiticide. Tiabendazole works by inhibition of the mitochondrial, helminth-specific enzyme, fumarate reductase, with possible interaction with endogenous quinone. Tiabendazole serves to block angiogenesis in both frog embryos and human cells. It has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels. Tiabendazole has been shown to effectively do this in certain cancer cells.


Chemical Structure

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Thiabendazole
CAS# 148-79-8

Theoretical Analysis

MedKoo Cat#: 318857
Name: Thiabendazole
CAS#: 148-79-8
Chemical Formula: C10H7N3S
Exact Mass: 201.03607
Molecular Weight: 201.247
Elemental Analysis: C, 59.68; H, 3.51; N, 20.88; S, 15.93

Price and Availability

Size Price Availability Quantity
10.0g USD 120.0 2 Weeks
20.0g USD 150.0 2 Weeks
50.0g USD 250.0 2 Weeks
100.0g USD 450.0 2 Weeks
200.0g USD 750.0 2 Weeks
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Synonym: TBZ; Thibendole; Thiabendazol; Thiabendazole. Trade names Mintezol, Tresaderm, Arbotec; Mintesol; Omnizole.

IUPAC/Chemical Name: 4-(1H-1,3-benzodiazol-2-yl)-1,3-thiazole

InChi Key: WJCNZQLZVWNLKY-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)

SMILES Code: C1(C2=NC3=CC=CC=C3N2)=CSC=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 201.247 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lönngren V, Holst E, Ljunggren B. Larval papulonodular dermatitis treated with
topical tiabendazole. Lancet Infect Dis. 2010 Jul;10(7):504. doi:
10.1016/S1473-3099(10)70104-3. PubMed PMID: 20610333.

2: Baliharová V, Skálová L, Maas RF, De Vrieze G, Bull S, Fink-Gremmels J. The
effects of mebendazole on P4501A activity in rat hepatocytes and HepG2 cells.
Comparison with tiabendazole and omeprazole. J Pharm Pharmacol. 2003
Jun;55(6):773-81. PubMed PMID: 12841937.

3: Fourestié V, Bougnoux ME, Ancelle T, Liance M, Roudot-Thoraval F, Naga H,
Pairon-Pennachioni M, Rauss A, Lejonc JL. Randomized trial of albendazole versus
tiabendazole plus flubendazole during an outbreak of human trichinellosis.
Parasitol Res. 1988;75(1):36-41. PubMed PMID: 3060872.