WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206483
CAS#: 1239875-86-5
Description: SGI-7079 is a potent and selective Axl inhibitor with potential anticancer activity. SGI-7079 effectively inhibited Axl activation in the presence of exogenous Gas6 ligand. SGI-7079 inhibited tumor growth in a dose dependent manner. Axl is a potential therapeutic target for overcoming EGFR inhibitor resistance.
MedKoo Cat#: 206483
Name: SGI-7079
CAS#: 1239875-86-5
Chemical Formula: C26H26FN7
Exact Mass: 455.22337
Molecular Weight: 455.5414
Elemental Analysis: C, 68.55; H, 5.75; F, 4.17; N, 21.52
Synonym: SGI-7079; SGI 7079; SGI7079.
IUPAC/Chemical Name: 2-(3-(2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)acetonitrile
InChi Key: BCFKACXAIBEPKR-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H26FN7/c1-17-16-29-25-23(17)24(19-5-3-4-18(14-19)8-9-28)31-26(32-25)30-20-6-7-22(21(27)15-20)34-12-10-33(2)11-13-34/h3-7,14-16H,8,10-13H2,1-2H3,(H2,29,30,31,32)
SMILES Code: N#CCC1=CC=CC(C2=C3C(NC=C3C)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1
1: Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward WA, Reuben JM,
Warner SL, Bearss DJ, Hortobagyi GN, Hung MC, Ueno NT. TIG1 promotes the
development and progression of inflammatory breast cancer through activation of
Axl kinase. Cancer Res. 2013 Nov 1;73(21):6516-25. doi:
10.1158/0008-5472.CAN-13-0967. Epub 2013 Sep 6. PubMed PMID: 24014597.
2: Byers LA, Diao L, Wang J, Saintigny P, Girard L, Peyton M, Shen L, Fan Y, Giri
U, Tumula PK, Nilsson MB, Gudikote J, Tran H, Cardnell RJ, Bearss DJ, Warner SL,
Foulks JM, Kanner SB, Gandhi V, Krett N, Rosen ST, Kim ES, Herbst RS,
Blumenschein GR, Lee JJ, Lippman SM, Ang KK, Mills GB, Hong WK, Weinstein JN,
Wistuba II, Coombes KR, Minna JD, Heymach JV. An epithelial-mesenchymal
transition gene signature predicts resistance to EGFR and PI3K inhibitors and
identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
Clin Cancer Res. 2013 Jan 1;19(1):279-90. doi: 10.1158/1078-0432.CCR-12-1558.
Epub 2012 Oct 22. PubMed PMID: 23091115; PubMed Central PMCID: PMC3567921.