WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522503
CAS#: 1240308-45-5
Description: A‑971432 is a potent, orally bioavailable, selective Sphingosine-1-Phosphate Receptor 5 (S1P5) agonist for the potential treatment of neurodegenerative disorders. A‑971432 is highly selective for S1P5 and has excellent plasma and CNS exposure after oral dosing in preclinical species. A‑971432 improves blood−brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonism is an innovative approach with potentialbenefit in neurodegenerative disorders involving lipid imbalance and/or compromised blood−brain barrier such as Alzheimer’s disease or multiple sclerosis.
MedKoo Cat#: 522503
Name: A‑971432
CAS#: 1240308-45-5
Chemical Formula: C18H17Cl2NO3
Exact Mass: 365.05855
Molecular Weight: 366.238
Elemental Analysis: C, 59.03; H, 4.68; Cl, 19.36; N, 3.82; O, 13.11
Synonym: A‑971432; A 971432; A971432.
IUPAC/Chemical Name: 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid
InChi Key: WAAWETUDFSIYSD-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23)
SMILES Code: O=C(C1CN(CC2=CC=C(OCC3=CC=C(Cl)C(Cl)=C3)C=C2)C1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 366.238 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hobson AD, Harris CM, van der Kam E, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull J, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK. Discovery of A-971432, an Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonists for the Potential Treatment of Neurodegenerative Disorders. J Med Chem. 2015 Oct 28. [Epub ahead of print] PubMed PMID: 26509640.
