Carglumic Acid
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MedKoo CAT#: 317372

CAS#: 1188-38-1

Description: Carglumic acid is an orphan drug, marketed by Orphan Europe under the trade name Carbaglu. Carglumic acid is used for the treatment of hyperammonaemia in patients with N-acetylglutamate synthase deficiency. The initial daily dose ranges from 100 to 250 mg/kg, adjusted thereafter to maintain normal plasma levels of ammonia.


Chemical Structure

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Carglumic Acid
CAS# 1188-38-1

Theoretical Analysis

MedKoo Cat#: 317372
Name: Carglumic Acid
CAS#: 1188-38-1
Chemical Formula: C6H10N2O5
Exact Mass: 190.05897
Molecular Weight: 190.154
Elemental Analysis: C, 37.90; H, 5.30; N, 14.73; O, 42.07

Size Price Shipping out time Quantity
10mg USD 80 2 Weeks
25mg USD 90 2 Weeks
50mg USD 120 2 Weeks
100mg USD 150 2 Weeks
200mg USD 250 2 Weeks
500mg USD 450 2 Weeks
1g USD 750 2 Weeks
2g USD 1250 2 Weeks
5g USD 2650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-03-07. Prices are subject to change without notice.

Carglumic acid, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Synonym: OE312, OE-312, OE 312, AJ 266447, AJ-26647, AJ26647; Carglumic Acid.

IUPAC/Chemical Name: (2S)-2-(carbamoylamino)pentanedioic acid

InChi Key: LCQLHJZYVOQKHU-VKHMYHEASA-N

InChi Code: InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1

SMILES Code: O=C(O)[C@@H](NC(N)=O)CCC(O)=O

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Handling Instructions:

Preparing Stock Solutions

The following data is based on the product molecular weight 190.154 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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Dilution Calculator

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1: Matoori S, Leroux JC. Recent advances in the treatment of hyperammonemia. Adv
Drug Deliv Rev. 2015 Aug 1;90:55-68. doi: 10.1016/j.addr.2015.04.009. Epub 2015
Apr 17. Review. PubMed PMID: 25895618.

2: van Karnebeek C, Häberle J. Carbonic Anhydrase VA Deficiency. 2015 Apr 2. In:
Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong
CT, Mefford HC, Smith RJH, Stephens K, editors. GeneReviews® [Internet]. Seattle
(WA): University of Washington, Seattle; 1993-2015. Available from
http://www.ncbi.nlm.nih.gov/books/NBK284774/
PubMed PMID: 25834911.