Carbinoxamine Maleate

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MedKoo CAT#: 317371

CAS#: 3505-38-2 (Carbinoxamine Maleate)

Description: Carbinoxamine Maleate is a antihistamine and anticholinergic agent. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid. It is approved by the U.S. Food and Drug Administration (FDA) (specifically at the 4 mg dose/strength) for hay fever (a.k.a. allergic rhinitis, SAR and PAR); vasomotor rhinitis; mild urticaria; angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist.

Chemical Structure

Carbinoxamine Maleate
CAS# 3505-38-2 (Carbinoxamine Maleate)

Theoretical Analysis

MedKoo Cat#: 317371
Name: Carbinoxamine Maleate
CAS#: 3505-38-2 (Carbinoxamine Maleate)
Chemical Formula: C20H23ClN2O5
Exact Mass:
Molecular Weight: 406.86
Elemental Analysis: C, 59.04; H, 5.70; Cl, 8.71; N, 6.89; O, 19.66

Price and Availability

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100.0mg USD 290.0 2 Weeks
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Related CAS #: 3505-38-2 (Carbinoxamine Maleate)   486-16-8 (Carbinoxamine)  

Synonym: Histex CT, Clistin, Palgic, Rondec, Rhinopront, Carbinoxamine.

IUPAC/Chemical Name: 2-((4-chlorophenyl)(pyridin-2-yl)methoxy)-N,N-dimethylethan-1-amine maleate


InChi Code: InChI=1S/C16H19ClN2O.C4H4O4/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-10,16H,11-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: CN(C)CCOC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 406.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Moustafa AA, Hegazy MA, Mohamed D, Ali O. Evaluation of multivariate
calibration models with different pre-processing and processing algorithms for a
novel resolution and quantitation of spectrally overlapped quaternary mixture in
syrup. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Feb 5;154:76-83. doi:
10.1016/j.saa.2015.10.010. Epub 2015 Oct 22. PubMed PMID: 26519913.

2: Wang X, Yang H, Zhou B, Wang X, Xie Y. Effect of oxidation on amine-based
pharmaceutical degradation and N-Nitrosodimethylamine formation. Water Res. 2015
Jul 29;87:403-411. doi: 10.1016/j.watres.2015.07.045. [Epub ahead of print]
PubMed PMID: 26469132.